A5046628237- Chemokine receptors and signaling
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- Genetic factors in colorectal cancer
- Vitamin C and Antioxidants Research
- Immunotherapy and Immune Responses
- interferon and immune responses
- Inflammatory mediators and NSAID effects
- Tumors and Oncological Cases
- Hedgehog Signaling Pathway Studies
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
- Peptidase Inhibition and Analysis
- Ear and Head Tumors
- Oral Health Pathology and Treatment
Ehime University
2019-2025
Kumamoto University
2024
Dokkyo Medical University
2016-2020
Kamituga General Hospital
2019-2020
Dokkyo University
2017-2018
Tokushima University
2009-2015
Showa University
1994-1997
The University of Tokyo
1996
Candida is a yeast commonly found in various environments. It usually coexists with the skin without causing harm. may exhibit pathogenicity when local or systemic immune defense mechanisms are compromised, which creates conditions favorable for its proliferation. This report discusses case of invasive cutaneous candidiasis rib osteomyelitis that developed at donor site pectoralis major myocutaneous flap. The patient was 58-year-old man who underwent reconstruction flap adenoid cystic...
Abstract Mutations in p53 are common human oral squamous cell carcinoma (OSCC). However, previous analyses, only detection of mutant protein using immunohistochemistry or mutations some exons have been examined. Full length many cases shows a loss tumor suppressor function, but possibly gain oncogenic function. In this study, we investigate relationships outcomes with the mutational spectrum (missense and truncation mutations) whole exon OSCC. Specimens from biopsy surgery (67 cases) were...
We have demonstrated that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in establishment of lymph node metastasis oral squamous cell carcinoma (SCC). Chemotherapy a powerful tool for treatment cancer, including SCC; however, effects chemotherapeutic agents on expression CXCR4 are unknown. In this study, we examined associated with cancer cells. The was using 3 different agents; 5-fluorouracil, cisplatin, and vesnarinone...
MicroRNAs (miRNAs) can act not only as tumor suppressor genes but also oncogenes. Oncogenic miRNAs (oncomiRs) could therefore provide opportunities for the treatment of human malignancies. Here, we aimed to identify oncomiRs present in oral squamous cell carcinoma (OSCC) and addressed whether targeting these might be useful cancer. Functional screening a OSCC line (GFP-SAS) was carried out using miRCURY LNA microRNA Knockdown Library - Human version 12.0. We identified locked nucleic acid...
Human papillomavirus (HPV) is a possible carcinogenetic factor in oral squamous cell carcinoma (OSCC). Previous studies have reported the prevalence of HPV patients with OSCC. However, association between and OSCC remains controversial. The present study aimed to clarify infection, p16 protein expression clinicopathological characteristics level HPV‑16E6 mRNA protein, known surrogate marker was investigated 100 cases using TaqMan reverse transcription‑quantitative PCR immunohistochemistry...
Oral cancer cells have a significantly augmented nuclear factor-κB (NF-κB) activity and the inhibition of this suppresses tumor growth. Bortezomib is proteasome inhibitor drug used for molecular-targeted therapy (targets NF-κB). In study, we investigated whether bortezomib would be effective as an proliferation radiosensitizer treatment oral cancer. We demonstrate that inhibits NF-κB cell proliferation. The combined with radiation (RT) suppressed growth in vitro vivo compared RT alone. To...
Docetaxel (DOC) and 5-fluorouracil (5-FU) are important anticancer agents widely used in the treatment of a variety cancers including oral squamous cell carcinoma (OSCC). The purpose this study was to determine antitumor efficacy sequential administration DOC 5-FU against OSCC cells (B88 CAL27 cells) vitro vivo. In growth inhibition assays, with followed by more effective inhibiting cancer than DOC, single or 5-FU, combined 5-FU. Furthermore, significantly inhibited tumor vivo compared DOC....
We have demonstrated that blocking CXCR4 may be a potent anti-metastatic therapy for CXCR4-related oral cancer. However, as antagonists are currently in clinical use to induce the mobilization of hematopoietic stem cells, continuous administration an inhibitor metastasis lead persistent leukocytosis. In this study, we investigated novel therapeutic downstream target(s) SDF-1/CXCR4 system, using B88-SDF-1 which autocrine system and exhibit distant metastatic potential vivo. Microarray...
We have previously demonstrated that a stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of metastasis oral cancer. Recently, small non coding RNAs, microRNAs (miRNAs) been shown to be metastatic process several types cancers. However, miRNAs contribute metastases induced by SDF-1/CXCR4 cancer are largely unknown. In this study, we examined metastasis-related using B88-SDF-1 cells, which exhibit functional CXCR4 and distant potential vivo. Through...
Abstract This study investigates the role of interleukin (IL)-6 in oral squamous cell carcinoma (OSCC), evaluating its potential as a prognostic marker and therapeutic target. involved 95 untreated OSCC patients, with pre-surgical serum IL-6 levels measured by Electro chemiluminescence immunoassay (ECLIA). Patients were categorized into high (78 patients) low (17 groups based on cutoff value 8 pg/mL.A strong correlation was observed between higher lower overall survival (P<0.0001)...
In recent years, a wide variety of materials have been used in dental implant treatment. selecting the superstructures and abutments to be it is important consider their potential effect on stability durability planned implant. Excessive force applied an during maintenance commonly results complications, such as fracture superstructure or abutment, loosening screws. This report describes case treatment for 23-year-old man with esthetic disturbance due trauma maxillary anterior teeth. The...
It is widely known that human malignancies are caused by genomic and epigenomic alterations. In oral squamous cell carcinoma(OSCC), numerous gene alterations have also been reported. However, in clinical practice, these findings not utilized at all. Therefore, we attempted to identify would be useful the diagnosis treatment of OSCC. First, extracted DNA total RNA from primary tumor adjacent normal tissues, respectively. Subsequently, targeted ultradeep sequencing a next-generation sequencer...
Aim: We attempted to clarify the role of Peroxisome proliferator-activated receptor γ (PPARγ) and its ligand, troglitazone (TRO) on oral squamous cell carcinoma (SCC). Materials Methods: The expression PPARγ gene was examined in 47 human SCC tissues two lines, CA9-22 HSC-4. effects TRO growth cell-cycle progression cells were examined. Results: mRNA detected 20 cells. significantly suppressed cells, but did not induce apoptosis. treated with showed an increased fraction G<sub>1</sub> phase...
Molecules that demonstrate a clear association with the aggressiveness of oral squamous cell carcinoma (OSCC) have not yet been identified. The current study hypothesized tumor cells in OSCC three different origins: Epithelial stem cells, tissue from salivary gland and bone marrow (BM) cells. It was also carcinomas derived less‑differentiated greater malignancy. In present study, sex chromosome analysis by fluorescence <em>in situ</em> hybridization and/or microdissection PCR performed...
Ascorbic acid-induced fragmentation of DNA in human myelogenous leukemic cell lines (HL-60, ML-1), as judged by agarose gel electrophoresis, fluorometric determination (DAPI method), or flow cytometry, was studied. acid induced no detectable peripheral blood monocytes, lymphocytes polymorphonuclear cells. Minimum exposure time required for the onset apoptosis 30 min. Addition catalase completely blocked ascorbic acid. Fragmentation could be hydrogen peroxide, but not sodium hypochlorite. The...