Background The relevance of lysophosphatidylcholine acyltransferase1 (LPCAT1), a cytosolic enzyme in the remodeling pathway phosphatidylcholine metabolism, oral squamous cell carcinoma (OSCC) is unknown. We investigated LPCAT1 expression and its functional mechanism OSCCs. Methods analyzed mRNA protein levels OSCC-derived lines. Immunohistochemistry was performed to identify correlations between primary OSCCs clinicopathological status. established knockdown models lines (SAS, Ca9-22) for...

The WW domain containing E3 ubiquitin protein ligase 2 (WWP2) encodes a member of the Nedd4 family ligases, which catalyzes final step ubiquitination cascade. WWP2 is involved in tumoral growth with degradation tumor suppressor phosphatase and tensin homologue deleted on chromosome TEN (PTEN). However, little known about mechanisms roles human malignancies including oral squamous cell carcinomas (OSCCs). We found frequent overexpression all OSCC-derived lines examined that was associated...

Abstract Background Glutamate decarboxylase 1 (GAD1), a rate-limiting enzyme in the production of γ-aminobutyric acid (GABA), is found GABAergic neurons central nervous system. Little known about relevance GAD1 to oral squamous cell carcinoma (OSCC). We investigated expression status and its functional mechanisms OSCCs. Methods evaluated mRNA protein expressions OSCC-derived cells using real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) immunoblotting analyses....

Abstract Mutations in p53 are common human oral squamous cell carcinoma (OSCC). However, previous analyses, only detection of mutant protein using immunohistochemistry or mutations some exons have been examined. Full length many cases shows a loss tumor suppressor function, but possibly gain oncogenic function. In this study, we investigate relationships outcomes with the mutational spectrum (missense and truncation mutations) whole exon OSCC. Specimens from biopsy surgery (67 cases) were...

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases, oral cancer. Cancer cells usually escape from the immune system and acquire proliferative capacity invasive/metastatic potential. We have focused on two checkpoints, PD-1/PD-L1 CD47/SIRPα, in tumor microenvironment of squamous carcinoma (OSCC), performed a retrospective analysis expression seven immune-related...

Oral squamous cell carcinoma (OSCC) histopathologically accounts for ≥90% of oral cancer. Many clinicopathological risk factors OSCC have also been proposed, and postoperative therapy is recommended in guidelines based on cancer stage other factors. However, even if the standard treatment provided according to guidelines, a few cases rapidly recur or show cervical distant metastasis. In this review article, we focus diversity origin OSCC. We discuss stem cells (CSCs) as key player explain...

Cavin-2 (CVN2) affects formation of large caveolae, which are membrane-rich cholesterol domains associated with several functions in signal transduction. Accumulating evidence suggests that CVN2 is present many cellular types; however, the molecular mechanisms cancers and its clinical relevance unknown. We proposed a mechanism by regulates caveolin-1 expression leading to slow proliferation inactivation extracellular regulated kinase (ERK) pathway. Quantitative reverse...

The surveillance methods oral squamous cell carcinoma (OSCC) patients may be chosen by considering the risk for recurrence, and it is important to establish appropriate during period in which latent/dormant cancer cells become more apparent. To investigate of with OSCC based on individual recurrence and/or metastasis, we performed a retrospective cohort study after complete surgical resection as primary treatment.The was 324 who had been primarily treated surgery from 2007 2020 at our...

Administration of cetuximab (C-mab) in combination with paclitaxel (PTX) has been used for patients head and neck squamous cell carcinoma (SCC) clinically. In this study, we attempted to clarify the molecular mechanisms enhancing anticancer effect C-mab combined PTX on oral SCC cells vitro. We two (HSC4, OSC19) A431 cells. alone inhibited growth all a concentration-dependent manner. OSC19 at low concentrations, but HSC4 very weakly, even high concentrations. A drugs was moderate cells,...

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases oral cancer. Cancer cells usually escape from immune system and acquire proliferative capacity invasive/metastatic potential. We have focused on the two checkpoints, PD-1/PD-L1 CD47/SIRPα in tumor microenvironment of squamous carcinoma (OSCC), performed a retrospective analysis expression seven immune-related...

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease, and an apparent cause has not been identified. OLP refractory to treatment, malignant transformation reported. Therefore, discovering effective drugs with few adverse effects over long-term administration crucial. In this study, we established in vitro model investigate the of Cepharanthin®, alkaloid mixture derived from Stephania cephalantha Hayata. Four alkaloids Cepharanthin® suppressed expression cytokine genes at...

A retrospective cohort study was performed to investigate the effectiveness of preemptive postsurgical therapy with cetuximab for patients a major risk recurrence or metastasis after clinical complete resection primary oral squamous cell carcinoma (OSCC). The period from 2007 2019 treated at Department Oral and Maxillofacial Surgery, Dokkyo Medical University School Medicine. OSCC (n = 88) in follow-up were divided into groups no treatment (NP group), standard (SP including (CP prognosis...

Abstract Background The status of oral cancer therapy in elderly patients Japan, where ageing is rapidly progressing, may serve as a model for other countries with similar demographics. There controversy over what kind treatment should be applied and how aggressively it to very who have exceeded the average life expectancy. Given that 85 years approximately overall Japanese expectancy at birth, we considered threshold hypothesized prognosis squamous cell carcinoma (SCC) aged ≥85 was not...

Background/Aim: Odontogenic diseases are diagnosed based on clinical course, imaging, and histopathology. However, a definitive diagnosis is not always possible. Patients Methods: We analyzed whole exons of SMO, BRAF, PTCH1 GNAS using next-generation sequencing (NGS) in 18 patients. Results: Of the 6 patients with ameloblastoma, 2 had same missense mutation 1 patient peripheral ameloblastoma PTCH1. 7 odontogenic keratocyst, 4 PTCH1, mutations SMO. The odontoma BRAF One cement-osseous...

Aim: We attempted to clarify the role of Peroxisome proliferator-activated receptor γ (PPARγ) and its ligand, troglitazone (TRO) on oral squamous cell carcinoma (SCC). Materials Methods: The expression PPARγ gene was examined in 47 human SCC tissues two lines, CA9-22 HSC-4. effects TRO growth cell-cycle progression cells were examined. Results: mRNA detected 20 cells. significantly suppressed cells, but did not induce apoptosis. treated with showed an increased fraction G₁ phase...

Molecules that demonstrate a clear association with the aggressiveness of oral squamous cell carcinoma (OSCC) have not yet been identified. The current study hypothesized tumor cells in OSCC three different origins: Epithelial stem cells, tissue from salivary gland and bone marrow (BM) cells. It was also carcinomas derived less‑differentiated greater malignancy. In present study, sex chromosome analysis by fluorescence <em>in situ</em> hybridization and/or microdissection PCR performed...

TSC-22 (TGF-β stimulated clone-22) has been reported to induce differentiation, growth inhibition, and apoptosis in various cells. is a member of family which many proteins are produced from four different genes. (corresponding TSC22D1-2) composed 144 amino acids translated short variant mRNA the TSC22D1 gene. In this study, we attempted determine intracellular localizations (TSC22D1-1, (TSC22D1-2), TSC22(86) (TSC22D1-3)) identify binding for by mass spectrometry. We determined that...

The main symptom in primary syphilis is a small, painless, sore or ulcer called chancre on the penis, vagina, around anus, although chancres can sometimes appear mouth lips, fingers, buttocks. We present case of man his early 60 s with chief complaint painful tongue ulcer. An ulcerated, indurated, and hemorrhagic lesion (23 × 14 mm) was found ventral surface, near oral floor. Palpation identified several swollen, mobile, elastic cervical lymph nodes, no tenderness. initially diagnosed...

In this review article, we focus on the diversity of origin oral squamous cell carcinoma(OSCC), and discuss cancer stem cells(CSCs) as a key player to explain malignancy OSCC. CSCs are subset cells that have characteristics cells. When gene abnormalities accumulate in somatic cells, those transform into CSCs. autonomously grow develop cancer. We hypothesize OSCC may be divided following three categories with different based CSCs: from epithelial cell-derived CSCs, salivary gland-derived bone...

Abstract Reactive bone growth is often clinically difficult to distinguish from true tumors, and both types of lesion are frequently lumped together as “osteomas.” We carried out surgical resection an osteoma on the inferior border mandible a patient with no history mechanical stimulus or trauma that showed autonomous over time imaging assessments. were therefore considered this tumor, report case discussion literature. It important resect lesions sufficient safety margin when classified...

An 89-year-old woman visited our hospital requesting the examination of a papillary mass in posterior region right buccal mucosa. The orthopantomography and contrast-enhanced CT images showed lesion existing near mandibular ramus toward muscular process, posterolateral maxilla temporal fossa. boundary was unclear. Biopsy taken twice general pathologists tentatively diagnosed as papilloma. However, since seemed invasive, we an oral pathologist suspected possibly invasive tumor, surgical...

Introduction. Large maxillary cysts occasionally expand into the maxilla and erode sinus nasal cavity. The Caldwell-Luc procedure is recommended treatment for large cysts. However, it hard to preserve space in case of that penetrate Methods. A 22-year-old man who had was referred our department a surgical treatment. After removing cyst from using procedure, we used airway balloon catheter devices inferior meatus sinus. These were removed 10 days postoperatively. Insertion removal both simple...

Ectodermal dysplasia (ED), which is classified into three categories (anhidrotic, hypohidrotic, and hidrotic type), a hereditary disease characerized by abnormal development of ectodermal tissues organs. In the oral region, anodontia or oligodontia main feature anhidrotic hypohidrotic ED. However, intraoral symptoms in patients with ED have not been reported. We describe case ED, an uncommon subtype, associated two large dentigerous cysts, expanded maxilla, eroded maxillary sinuses,...