A5102805761- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Drug-Induced Ocular Toxicity
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Connexins and lens biology
- Retinal and Optic Conditions
- Cancer, Hypoxia, and Metabolism
- Ocular Infections and Treatments
- Cell Adhesion Molecules Research
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Neurological Complications and Syndromes
- Neurological and metabolic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cerebral Venous Sinus Thrombosis
- Aldose Reductase and Taurine
- Vascular Malformations Diagnosis and Treatment
- Vasculitis and related conditions
- Advanced Glycation End Products research
Yamaguchi University
2013-2025
Yamaguchi University Hospital
2024
Ube (Japan)
2008
<b><i>Introduction:</i></b> Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors, used in the treatment of renal anemia, hold potential to increase production vascular endothelial growth factors. Therefore, HIF-PH inhibitors may exacerbate retinal hemorrhage diseases such as diabetic retinopathy. Here, we present a case involving administration an inhibitor, resulting exacerbation patient with <b><i>Case Presentation:</i></b> A...
Background/Objectives: In a recent study, we investigated anti-VEGF treatment strategies for three subtypes of neovascular age-related macular degeneration (nAMD)—typical AMD (tAMD), polypoidal choroidal vasculopathy (PCV), and retinal angiomatous proliferation (RAP)—among large cohort Japanese patients. To further explore these findings, conducted post hoc analysis this to identify factors associated with the discontinuation therapy nAMD in real-world clinical setting. Methods: We collected...
To characterize wound closure and phenotypic changes in the corneal epithelium of Goto-Kakizaki (GK) rat, a spontaneous model type 2 diabetes.Corneal healing was monitored by fluorescein staining after epithelial debridement. Tear secretion measured with Schirmer test, sensation evaluated an esthesiometer 13- to 15-week-old GK Wistar (control) rats. The distributions cytokeratin 12 (K12), K14, connexin43 were examined immunohistofluorescence analysis. proliferation capacity cells intact...
ABSTRACT Mechanical stimulation as a mimic of drusen formation in the eye increases expression angiogenic factors retinal pigment epithelial (RPE) cells, but underlying molecular mechanisms remain unclear. We investigated and characterized effects mechanical on RPE cells both vitro mouse model. increased vascular endothelial growth factor (VEGF, encoded by VEGFA) other angiogenesis-related genes cultured RPE1 cells. The presence hypoxia-inducible 1α (HIF-1α, HIF1A) was also increased,...
Collagen contraction mediated by retinal pigment epithelial (RPE) cells contributes to the pathogenesis of proliferative vitreoretinopathy (PVR). We examined effects sex hormones on this process.Mouse RPE were cultured in a type I collagen gel and exposed 17β-estradiol, progesterone, or dehydro-epiandrosterone. induced transforming growth factor-β2 (TGF-β2) was determined measurement diameter. Expression α-smooth muscle actin (α-SMA), as well phosphorylation Smad2 myosin light chain (MLC),...
Abstract Epithelial–mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells plays a key role proliferative diseases such as age-related macular degeneration by contributing to subretinal fibrosis. To investigate the potential of retinoic acid receptor-α (RAR-α) signaling this process, we have now examined effects RAR-α agonist Am580 on EMT induced transforming growth factor-β2 (TGF-β2) primary mouse RPE cultured three-dimensional type I collagen gel well fibrosis model. We...
To investigate the efficacy of ripasudil, a Rho kinase inhibitor, in reducing intraocular pressure (IOP) and medication scores anti-glaucoma drugs patients with ocular hypertension inflammation corticosteroid.The study included 11 diagnosed corticosteroid, all whom were prescribed ripasudil eye drops followed up for at least 2y after initiation treatment. IOP was measured using non-contact tonometer before enrollment each follow-up visit. The score glaucoma calculated patient.The mean...
To evaluate the safety and efficacy of benzalkonium chloride (BAK)-optimized tafluprost (with a BAK concentration reduced from 0.01% to 0.001%) in glaucoma patients with existing superficial punctate keratitis (SPK).A prospective, multicenter, open-label study was designed compare BAK-optimized administered over 12 weeks relative other preserved prostaglandin analogs previously Japanese patients. Thirty SPK graded at <6 points by area density (AD) scoring 1 eye were recruited. The primary...
Mechanical stress regulates various biological processes in cells, tissues, and organs as well contributes to the pathogenesis of diseases. The retina is subjected mechanical imposed by intraocular pressure retinal hemorrhage edema. Responses have been studied pigment epithelial cells Müller retina, with former having found undergo a stress-induced increase expression vascular endothelial growth factor (VEGF), which plays key role physiological pathological angiogenesis retina. We here...
Macular edema is a known side effect of taxane-based anticancer drugs. We retrospectively investigated data from 11 centers between January 2016 and December 2021. Among 14,260 patients, 30 (0.21%) developed macular edema; these, the number cases associated with nab-paclitaxel was 16 (0.43%), significantly higher than paclitaxel or docetaxel (P < 0.01). Visual acuity (VA) retinal choroidal change were examined in 27 follow-up at least 3 months. The patients' mean age 67.2 years; 14 (51.3%)...
Age-related macular degeneration (AMD) is one of the leading causes blindness in elderly, affecting macula retina and resulting vision loss. There are two types AMD, wet dry, both which cause visual impairment. Wet AMD called neovascular (nAMD) characterized by formation choroidal vessels (CNVs) macula. nAMD can be treated with intravitreal injections vascular endothelial growth factor (VEGF) inhibitors, help improve vision. However, approximately half patients do not achieve satisfactory...
Administration of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the first-line for diabetic macular oedema (DME). However, some patients show no or insufficient response to repeated anti-VEGF injections. Therefore, it necessary identify factors that can predict this resistance against treatment. Presence microaneurysms (MAs) a predictor development and progression DME, but its relationship with treatment agents not well known. we aimed elucidate between...
We present a case of gastrointestinal stromal tumor (GIST) metastasis the rectal primary resisting chemotherapy to right orbit 15 years after excision lesion.A 79-year-old man was diagnosed with GIST at age 65 and underwent amputation. He hepatectomy for liver metastases 69 pericardiectomy pericardial 72 age. At 79 years, positron emission tomography-computed tomography revealed possibility 10 mm in size. Magnetic resonance imaging well-circumscribed mass × 12 deep medial rectus muscle...
<b><i>Introduction:</i></b> Post-vitrectomy cystoid macular edema (CME) can lead to failure of hole (MH) closure. We report 2 cases MH closure due post-vitrectomy CME, which were successfully treated using sub-Tenon triamcinolone acetonide (STTA) injection. <b><i>Case Presentations:</i></b> Case 1 involved a 72-year-old male patient with Gass Stage 3 in the right eye. He underwent pars plana vitrectomy (PPV), internal limiting membrane...
: Anti-vascular endothelial growth factor (VEGF) therapy is the first-line treatment for neovascular age-related macular degeneration (nvAMD). While proactive and adequate generally leads to better visual outcomes, various factors, including disease type, ocular findings, lifestyle, systemic status, affect prognosis in clinical settings. This study aimed identify factors that patients with nvAMD treated anti-VEGF therapy.
To measure the optimal anterior chamber pressure (ACP) for safe phacoemulsification using a new tube system with internal measurement function in porcine eye. The 20-gauge and 21-gauge straight tips yellow orange sleeves, respectively, were covered by test combined sensor measuring ACP. This was measured 20s from 10s after starting aspiration linear mode vacuum levels of 200 150 mm Hg tip, 300 250 tip. Using eye, fixed 0.9 corneal incision For posterior capsule contact assay, eyes treated as...
Purpose: To describe a case of bilateral corneal epithelial dysplasia in which each lesion was characterized by both laser confocal biomicroscopy and cytokeratin immunofluorescence. Methods: A 52-year-old Japanese woman with treated debridement. We observed the affected area before after treatment examined immunofluorescence cytokeratins to examine characteristics abnormal cells. Results: Laser revealed atypical cells all layers epithelium as well reconstituted normal structure...