A5017447225- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- DNA and Nucleic Acid Chemistry
- Ocular Diseases and Behçet’s Syndrome
- HIV/AIDS drug development and treatment
- Retinoids in leukemia and cellular processes
- Mosquito-borne diseases and control
- Advanced Glycation End Products research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Intraocular Surgery and Lenses
- Antioxidant Activity and Oxidative Stress
- Advanced biosensing and bioanalysis techniques
- Atherosclerosis and Cardiovascular Diseases
- RNA and protein synthesis mechanisms
- Retinopathy of Prematurity Studies
- Genomics, phytochemicals, and oxidative stress
- Complement system in diseases
- Molecular spectroscopy and chirality
- Retinal and Optic Conditions
- Optical Systems and Laser Technology
- Advanced optical system design
- Renal Diseases and Glomerulopathies
- Click Chemistry and Applications
Kobe University
2006-2017
Johns Hopkins University
1971-2014
Johns Hopkins Medicine
2010-2012
Argonne National Laboratory
1973-1976
University of California, Riverside
1967-1968
A nonsynonymous coding variant in the manganese superoxide dismutase (SOD2) gene (V16A, rs4880) has been implicated neovascular age-related macular degeneration (AMD). However, findings have inconsistent. Two studies Japanese populations reported an opposite direction of association same allele at V16A variant, whereas one study a Northern Irish population found no effect on risk developing AMD. To address these apparently contradictory reports, we validated population.In population,...
ADVERTISEMENT RETURN TO ISSUEArticleNEXTConformation and interaction of dinucleoside mono- diphosphates. 6. Influence the furanose on conformation adenine monophosphates in solutionN. S. Kondo, K. N. Fang, P. Miller, O. Ts'oCite this: Biochemistry 1972, 11, 1991–2003Publication Date (Print):May 1, 1972Publication History Published online1 May 2002Published inissue 1 1972https://pubs.acs.org/doi/10.1021/bi00761a001https://doi.org/10.1021/bi00761a001research-articleACS PublicationsRequest...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformation and interaction of dinucleoside mono- diphosphates. IV. Proton magnetic resonance study on adenine dideoxynucleoside monophosphate with emphasis the furanose conformationK. N. Fang, S. Kondo, P. Miller, O. Ts'oCite this: J. Am. Chem. Soc. 1971, 93, 24, 6647–6656Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December...
We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudative age-related macular degeneration (AMD) in prospective cohort. Four hundred and sixty-one treatment-naïve AMD patients were recruited at 13 clinical centers all treated with 3 monthly injections ranibizumab followed by pro re nata regimen one year. Genomic DNA was collected from 2-stage GWAS achieving dry macula after initial treatment, requirement an additional visual acuity changes during...
Purpose: To compare the association of age-related maculopathy susceptibility 2 (ARMS2) and complement factor H (CFH) variants between two different angiographic phenotypes polypoidal choroidal vasculopathy (PCV).Methods: We included 175 Japanese patients with PCV 150 age- sex-matched controls. was classified into (Type 1 Type 2) according to presence or absence feeding vessels found in indocyanine-green angiography. The single nucleotide polymorphism (SNP) at rs10490924 (A69S) ARMS2...
Age-related macular degeneration (AMD) is a leading cause of legal blindness among older individuals industrialized countries. In neovascular AMD, which an advanced stage choroidal neovascularization develops underneath the macula and destroys central vision. Oxidative stress hypothesized pathway for pathophysiology AMD. CD36 was chosen as candidate gene AMD because protein plays important role in this well angiogenesis maintaining chorioretinal homeostasis. We tested 19 tag single...
Background Genetic variants in the complement component 3 gene (C3) have been shown to be associated with age-related macular degeneration (AMD) Caucasian populations of European descent. In particular, a nonsynonymous coding variant, rs2230199 (R102G), is presumed most likely causal variant C3 locus based on strong statistical evidence for disease association and mechanistic functional evidence. However, risk allele absent or rare (<1%) Japanese Chinese populations, R102G AMD has not...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and proton magnetic resonance spectrum of a selectively deuterated dinucleoside monophosphate, adenylyl-(3'-5')-adenosineN. S. Kondo DanylukCite this: J. Am. Chem. Soc. 1972, 94, 14, 5121–5122Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://pubs.acs.org/doi/10.1021/ja00769a076https://doi.org/10.1021/ja00769a076research-articleACS PublicationsRequest reuse...
Purpose . Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). Bisphosphonates, the drug of choice to treat osteoporosis, have been recently reported anti-angiogenic effects. The purpose this study investigate therapeutic effects oral bisphosphonates for CNV in humans. Methods Thirty-six consecutive cases due AMD or PM who declined anti-VEGF therapy were recruited. patients prescribed 5 mg alendronates daily 6...
Purpose: Increases in matrix proteins, such as type I collagen and fibronectin, are observed with aging the retinal pigment epithelium (RPE) basement membrane. However, little is known about altered gene expression profiles of RPE associated increases proteins. We investigated changes a human cell line (ARPE-19) cultured on collagen. Methods: Visually confluent ARPE-19 cells were grown either Matrigel (M group) or (C without serum over 3 days. Total RNA was extracted reverse transcribed....