A5080948472- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Vascular Malformations Diagnosis and Treatment
- Optical Coherence Tomography Applications
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Retinopathy of Prematurity Studies
- Cerebral Venous Sinus Thrombosis
- Angiogenesis and VEGF in Cancer
- Ocular Oncology and Treatments
- Acute Ischemic Stroke Management
- Dermatological and Skeletal Disorders
- Pregnancy and preeclampsia studies
- Ocular and Laser Science Research
- Neuroscience and Neuropharmacology Research
- Optical Imaging and Spectroscopy Techniques
- Neonatal Respiratory Health Research
- Intraocular Surgery and Lenses
The University of Tokyo
2016-2025
Toranomon Hospital
2024-2025
University Hospital Kyoto Prefectural University of Medicine
2025
Saitama Red Cross Hospital
2005-2024
University of Tokyo Hospital
2017-2024
Bayer (France)
2024
Boehringer Ingelheim (India)
2024
Santen (United States)
2024
Pontifícia Universidade Católica do Paraná
2024
Tokyo Medical University
2023
To determine the significance of serum anti-GQ<sub>1b</sub> IgG antibody, we studied disease spectrum associated with this antibody and GQ<sub>1b</sub> epitope in human nervous system. We examined sera from 19 patients typical Miller Fisher syndrome (MFS), five acute postinfectious ophthalmoplegia without ataxia (atypical MFS), six Guillain-Barré (GBS) (GBS-OP[+]), 23 GBS (GBS-OP[-]). also 84 other neurologic or non-neurologic disorders 16 normal control subjects. Eighteen MFS, all atypical...
Abstract This case-control study reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) in Japan. The of 161 AMD cases from two university hospitals 369 population-based control subjects a cohort was assessed using brief-type self-administered questionnaire on diet history, which required respondent recall usual 58 foods during preceding month. Energy-adjusted values were compared groups. Logistic regression analysis used to estimate odds...
In Brief Purpose: To describe detailed clinical features of eyes with focal choroidal excavation. Methods: Twenty-one 17 patients excavation were retrospectively studied. All underwent thorough examination including funduscopy, visual field analysis, fundus autofluorescence imaging, fluorescein angiography, indocyanine green and B-scan ultrasonography. Results: Patients' age ranged between 25 years 70 years. Four (24%) affected bilaterally. Spherical equivalent refractive error from 0.5...
Corneal biomechanical properties are associated with axial elongation. We aimed to characterize corneal in highly myopic eyes maculopathy (MM). Retrospective cross-sectional study. included patients examined between June 2022 and August 2023, who underwent visualization Scheimpflug technology (Corvis ST) measurements. MM (axial length >26.0 mm) was evaluated using META-PM classification based on fundus photographs subfoveal choroidal thickness measured via spectral domain OCT. A linear mixed...
Purpose: To investigate changes in melanin distribution and retinal sensitivity following a pigment epithelium (RPE) tear neovascular age-related macular degeneration (nAMD). Methods: Five cases of nAMD with RPE tears involving the fovea within 1 month onset were examined. Using polarization-sensitive optical coherence tomography, entropy—a quantitative indicator distribution—was measured at baseline 6 months level Bruch’s membrane. Retinal was assessed microperimeter, entropy averaged...
The purpose of the current study is to investigate test-retest reproducibility visual fields (VFs) measured with MP-3 microperimeter, in patients retinitis pigmentosa (RP).VFs were twice and also Humphrey Field Analyzer, using 10-2 test grid pattern both perimeters, 30 eyes (15 right 15 left eyes) 18 RP (11 males 7 females). Test-retest was assessed mean absolute deviation (MAD) measure at all 68 points grid. Reproducibility evaluated intraclass correlation coefficient (ICC) VF...
The latent transforming growth factor (TGF)-beta binding proteins (LTBP)-1, -3 and -4 bind the form of multipotent cytokine TGF-beta. To examine function LTBPs, we made a null mutation Ltbp-3 by gene targeting. homozygous mutant animals developed cranio-facial malformations 12 days. By three months, there was pronounced rounding cranial vault, extension mandible beyond maxilla, kyphosis. osteosclerosis long bones vertebrae as well osteoarthritis between 6 9 months age. These latter...
Background/aims To validate a deep learning algorithm to diagnose glaucoma from fundus photography obtained with smartphone. Methods A training dataset consisting of 1364 colour photographs glaucomatous indications and 1768 without features was using an ordinary camera. The testing consisted 73 eyes patients 89 normative subjects. In the dataset, were acquired camera developed dataset. trained neural network evaluated by prediction result diagnostic or normal over test datasets, images both...
The EVEREST II study previously reported that intravitreally administered ranibizumab (IVR) combined with photodynamic therapy (PDT) achieved superior visual gain and polypoidal lesion closure compared to IVR alone in patients choroidal vasculopathy (PCV). This follow-up reports the long-term outcomes 6 years after initiation of study. is a non-interventional cohort 90 PCV from 16 international trial sites who originally completed were assessed during recall visit at about commencement II....
We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudative age-related macular degeneration (AMD) in prospective cohort. Four hundred and sixty-one treatment-naïve AMD patients were recruited at 13 clinical centers all treated with 3 monthly injections ranibizumab followed by pro re nata regimen one year. Genomic DNA was collected from 2-stage GWAS achieving dry macula after initial treatment, requirement an additional visual acuity changes during...
It has not been clarified whether early age-related macular degeneration (AMD) is associated with cone photoreceptor distribution. We used adaptive optics fundus camera to examine photoreceptors in the area of aged patients and quantitatively analyzed its relationship between presence AMD distribution.Sixty cases 50 or older were studied. The eyes examined funduscopy spectral-domain optical coherence tomography exclude any abnormalities at two sites measurement, 2° superior 5° temporal...
The purpose of the current study was to investigate structure-function relationship in patients with retinitis pigmentosa (RP) using optical coherence tomography and MP-3 microperimeter. Visual field (VF) measurements were carried out microperimetry Humphrey Field Analyzer (HFA, Carl-Zeiss, CA), 22 eyes 11 a clinical diagnosis RP, both 10-2 test grid pattern. Optical (OCT, Spectralis, Heidelberg, Germany) also performed ellipsoid zone (EZ) identified OCT image. mean (±SD) number points...
Abstract Central serous chorioretinopathy (CSC) usually resolves spontaneously; however, in some patients, it can be chronic and visual impairment remains even after resolution of the retinal detachment. The impaired photoreceptor cells often present with disrupted ellipsoid zone (EZ) on optical coherence tomography (OCT). In this study, integrity EZ was quantified by calculating index residual EZ, identified binarized OCT images from 25 eyes 23 patients resolved CSC. To estimate central...
Pachychoroid neovasculopathy (PNV) shares some anatomical features with other pachychoroid spectrum diseases, but little is known about the characteristics on treatment anti-vascular endothelial growth factor (VEGF). We investigated effect of choroidal structure and responses to anti-VEGF prognosis types neovascular age-related macular degeneration (non-PNV). Twenty-one eyes PNV 34 non-PNV who had were retrospectively reviewed. Choroidal neovascularization (CNV) area at baseline was measured...
Abstract Imaging of melanin in the eye is important as structurally associated with some ocular diseases, such age-related macular degeneration. Although optical coherence tomography (OCT) cannot distinguish tissues containing from other intrinsically, polarization-sensitive OCT (PS-OCT) can detect through spatial depolarization backscattered light granules. Entropy one metrics that be used to malanin granules PS-OCT and valuable quantitative information on tissue abnormalities retrived by...
An oral, multitargeted receptor tyrosine kinase inhibitor, SU11248, inhibits vascular endothelial growth factor 2 (VEG FR2, domain F1K1), platelet-derived receptor, stem cell (Kit), and fetal liver 3. In this study, we administered SU11248 beyond the completion of an experimental choroidal neovascularization (CNV) model to determine whether CNV can be inhibited in vivo.C57B6J mice were treated with daily oral administration (40, 80, 150 mg/kg) during 5 days after diode laser...