A5033133061- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Vasculitis and related conditions
- Retinoids in leukemia and cellular processes
- Systemic Lupus Erythematosus Research
- Drug Transport and Resistance Mechanisms
- Ocular Infections and Treatments
- Syphilis Diagnosis and Treatment
- Photoreceptor and optogenetics research
- Ocular Oncology and Treatments
- Vascular Malformations Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Drug-Induced Ocular Toxicity
- Ubiquitin and proteasome pathways
- Ocular Surface and Contact Lens
- IgG4-Related and Inflammatory Diseases
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Complement system in diseases
Smith-Kettlewell Eye Research Institute
2020-2024
Stanford University
2020-2024
Kobe University
2015-2024
Stanford Medicine
2024
Kobe University Hospital
2019-2020
To describe a case of unilateral retinal arteriolar occlusion following multiple intravitreal brolucizumab injections for neovascular age-related macular degeneration (nAMD).A 92-year-old Caucasian woman presented with blurry vision in her left eye (OS) after receiving the third dose brolucizumab. At time presentation, visual acuity (VA) was 20/40 right (OD) and had decreased from 20/150 to count finger (CF) at 1-foot OS. On examination, there no evidence active inflammation anterior chamber...
To evaluate the functional and anatomical effects of switching to faricimab for patients with neovascular age-related macular degeneration (nAMD) refractory intravitreal aflibercept, this retrospective study evaluated nAMD who received injections aflibercept (IVA) every <8 weeks were switched faricimab. After switching, treated a treatment extended regimen that started interval just before at least three injections. We changes in best-corrected visual acuity (BCVA), central retinal thickness...
Background and Objectives: Faricimab is a novel bispecific antibody with Fab regions inhibiting both vascular endothelial growth factor-A angiopoietin-2. Therefore, this study aimed to obtain short-term outcomes of intravitreal injection faricimab (IVF) for the treatment diabetic macular edema (DME) in daily clinical practice. Materials Methods: A retrospective review was carried out on consecutive patients DME who had been treated IVF were followed up at least 1 month. Outcome measures...
The effects of intravitreal ranibizumab (IVR) against exudative age-related macular degeneration (AMD) may be different associated with the lesion phenotype. This study was conducted to compare outcomes IVR between two phenotypes AMD: typical neovascular AMD (tAMD) and polypoidal choroidal vasculopathy (PCV).This is a retrospective cohort 54 eyes from subfoveal patients (tAMD 24, PCV 30 eyes). Three consecutive treatments (0.5 mg) were performed every month, followed by re-injections as...
To report a case with multiple evanescent white dot syndrome (MEWDS) following BNT162b2 mRNA COVID-19 vaccination.Case: A 67-year-old Japanese female presented central visual field loss and photopsia in the right eye (OD) for 5 days. She was complaining blurred vision bright spots OD, but denied any ocular symptoms left (OS). had received second dose of vaccine (Pfizer-BioNTech) one day before onset symptoms; flu-like such as mild fever general fatigue also developed along decreased...
We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudative age-related macular degeneration (AMD) in prospective cohort. Four hundred and sixty-one treatment-naïve AMD patients were recruited at 13 clinical centers all treated with 3 monthly injections ranibizumab followed by pro re nata regimen one year. Genomic DNA was collected from 2-stage GWAS achieving dry macula after initial treatment, requirement an additional visual acuity changes during...
The effects of oxygen supplementation status and other clinical risk factors on the development severe retinopathy prematurity (ROP) were evaluated.Clinical records 143 newborn infants with a gestational age 32 weeks or less reviewed. Severe ROP was diagnosed when photocoagulation due to progression stage 3 identified 'plus disease' developed. evaluated univariate multivariate logistic regression analyses between groups (n = 24) non-severe 119) ROP.Gestational age, birth weight, duration...
Rebamipide with mucin secretagogue activity was recently approved for the treatment of dry eye. The efficacy and safety in rebamipide were shown two pivotal clinical trials. It aim this study to evaluate effect 2 % ophthalmic suspension patients eye analyze relevant factors favorable effects practice. This a retrospective cohort 48 eyes from 24 treated suspension. Dry eye-related symptom score, tear film break-up time (TBUT), fluorescein ocular surface staining score (FOS) Schirmer test used...
To describe structural changes in corneal epithelium using anterior segment optical coherence tomography (AS-OCT) two relapsed and refractory multiple myeloma (RRMM) patients with bilateral belantamab-associated superficial keratopathy (BASK).A 56-year-old male who was diagnosed RRMM initiated on belantamab mafodotin, presented day 42 (three weeks after the second infusion) decreased pinhole visual acuity from 20/20 20/25 to 20/70 20/50 right eye left eye, respectively. Slit-lamp examination...
Purpose . To evaluate the early response to intravitreal ranibizumab (IVR) in two different phenotypes of age-related macular degenerations (AMD): typical neovascular AMD (tAMD) and polypoidal choroidal vasculopathy (PCV). Methods Sixty eyes from 60 patients (tAMD 28, PCV 32 eyes) were recruited. Three consecutive IVR treatments (0.5 mg) performed every month. Change best-corrected visual acuity (BCVA) central retinal thickness (CRT) was then compared between tAMD groups. Results The mean...
<b><i>Background:</i></b> To compare the outcomes of photodynamic therapy (PDT) between two different angiographic subtypes polypoidal choroidal vasculopathy (PCV). <b><i>Methods:</i></b> Ninety-three consecutive cases PCV were classified into phenotypes (42 type 1 and 51 2) according to presence or absence feeding vessels found on indocyanine green angiography. Full-dose PDT retreatments performed every 3 months as needed based findings The...
Background Genetic variants in the complement component 3 gene (C3) have been shown to be associated with age-related macular degeneration (AMD) Caucasian populations of European descent. In particular, a nonsynonymous coding variant, rs2230199 (R102G), is presumed most likely causal variant C3 locus based on strong statistical evidence for disease association and mechanistic functional evidence. However, risk allele absent or rare (<1%) Japanese Chinese populations, R102G AMD has not...
To compare the association of elastin (ELN) gene variants between two different angiographic phenotypes polypoidal choroidal vasculopathy (PCV).We included 411 treatment-naïve PCV patients and 350 controls in present study. was classified into (152 Type 1 259 2) according to presence or absence feeding vessels found indocyanine-green angiography. Single nucleotide polymorphisms (SNPs) ELN region including rs868005, rs884843, rs2301995, rs13239907 rs2856728 were genotyped using TaqMan...