Erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), shows superior efficacy in patients with non-small cell lung cancer (NSCLC) harboring activating EGFR mutations (EGFR Mut+). However, almost all tumors eventually develop resistance to erlotinib. Recently, the Phase II JO25567 study reported significant prolongation of progression-free survival (PFS) by erlotinib plus bevacizumab combination compared Mut+ NSCLC. Herein, we established a preclinical model...

It has been reported that bevacizumab in combination with paclitaxel significantly prolongs progression-free survival compared alone the initial treatment for metastatic breast cancer. To understand how enhances efficacy of paclitaxel, we investigated mechanism a MX-1 human cancer xenograft model. The antitumor activity at 5 mg/kg 20 or 30 was higher than either agent alone. First, measured concentration tumor to see whether by increasing paclitaxel. When given bevacizumab, levels increased....

Previous preclinical and clinical findings have suggested a potential role of epidermal growth factor receptor (EGFR) in osteoclast differentiation the pathogenesis bone metastasis cancer. In this study, we investigated effect erlotinib, an orally active EGFR tyrosine kinase inhibitor (TKI), on invasion human non-small-cell lung cancer (NSCLC) cell line NCI-H292. First, established novel osteolytic model NCI-H292 cells which was made by inoculating into tibia scid mice. model, markedly...

Erlotinib (ERL), an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, shows notable efficacy against non–small cell lung cancer (NSCLC) harboring EGFR mutations. Bevacizumab (BEV), a humanized monoclonal antibody to vascular endothelial (VEGF), in combination with ERL (BEV+ERL) significantly extended progression‐free survival patients ‐mutated NSCLC compared alone. However, the of BEV+ERL T790M mutation or MET amplification, is unclear. Here, we examined antitumor activity...

It is important to compare the results of Corneal Visualization Scheimpflug Technology instrument (CST) measurements and Reichert Ocular Response Analyzer (ORA) parameters. The purpose study was investigate association between CST ORA parameters in ninety-five patients with primary open-angle glaucoma. Measurements CST, ORA, axial length (AL), average corneal curvature (CC), central thickness (CCT) intraocular pressure (IOP) Goldmann applanation tonometry (GAT) were carried out. assessed...

The purpose of the current study was to investigate structure-function relationship in patients with retinitis pigmentosa (RP) using optical coherence tomography and MP-3 microperimeter. Visual field (VF) measurements were carried out microperimetry Humphrey Field Analyzer (HFA, Carl-Zeiss, CA), 22 eyes 11 a clinical diagnosis RP, both 10-2 test grid pattern. Optical (OCT, Spectralis, Heidelberg, Germany) also performed ellipsoid zone (EZ) identified OCT image. mean (±SD) number points...

Aims Corvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on properties. In our accompanied paper, it was suggested that the repeatability of bIOP high. The purpose current study assess relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT) hysteresis (CH), in comparison Goldmann applanation tonometry (GAT) ocular response analyzer (ORA). Methods A total 141 eyes from subjects (35 healthy 106...

Purpose: To observe the morphology of corneal cells and nerve fibers in patients with type IV or V hereditary sensory autonomic neuropathy (HSAN) by vivo confocal microscopy elucidate mechanism leading to loss sensation this disease. Methods: In was performed on central cornea right eye 3 HSAN (ages 17, 20, 32 years), their compared that healthy subjects 28, 30, 36 years). Corneal tested a Cochet-Bonnet esthesiometer. Results: The superficial epithelial cell density lower (1525, 1225,...

Bevacizumab is a humanized monoclonal antibody to human vascular endothelial cell growth factor (VEGF) and has been used for many types of cancers such as colorectal cancer, non-small lung breast glioblastoma. might be effective against gastric because VEGF reported involved in the development cancer well other cancers. On hand, there are no established biomarkers predict bevacizumab efficacy spite clinical needs. Therefore, we tried identify predictive markers patients by using...

Purpose: To investigate the relationship between axial length (AL) elongation and progression of primary open-angle glaucoma (POAG). Methods: AL was measured twice over a 5.1 ± 0.76 (mean standard deviation: SD) year period in 125 eyes 72 patients with POAG. The were divided into not long (AL < 26 mm, 80 eyes) (>26 45 groups. During this period, patients' visual fields (VFs) Humphrey Field Analyzer 12.4 7.5 times intraocular pressure (IOP) Goldmann applanation tonometry 27.0 times. mean...

To construct a new item bank to measure quality of life (QOL) in glaucoma patients and evaluate patients' QOL using the bank.An questions was generated through literature review instruments useful for patients. Using this bank, cognitive survey performed on 203 with (112 males 91 females, 61.9±11.9 y old; mean±SD). The results were then analyzed Rasch analysis, Rasch-derived disability scores predicted linear modelling following clinical parameters: age, mean total deviation (mTD) superior...

To assess the repeatability of intraocular pressure (IOP) measured with Corvis ST (CST) and Ocular Response Analyzer (ORA).A total 141 eyes from subjects were studied, including 35 healthy 106 glaucomatous eyes. All underwent IOP evaluations Goldmann applanation tonometer, CST, ORA. With biomechanical corrected (bIOP) was calculated; bIOP is purported to be less dependent on properties. For ORA, corneal-compensated (IOPcc) Goldmann-correlated (IOPg) derived. The various values assessed using...

To assess the thickness of photoreceptor layer in macular region glaucomatous eyes.Humphrey 10-2 visual field (VF) testing was carried out and mean threshold (mTH) calculated 118 eyes from patients with open angle glaucoma. Macular optical coherence tomography (OCT) measurements (RS 3000, Nidek Co.ltd., Aichi, Japan) were also all eyes. Thickness recorded outer segment retinal pigment epithelium (OS+RPE), nerve fiber (NFL), ganglion cell inner plexiform (GCL+IPL), nuclear (INL+OPL) (ONL+IS)....

Purpose.: To develop and evaluate a method to map glaucomatous visual field (VF) damage by allocating additional test points the standard 6° interval VF pattern, considering distribution of scotomata. Methods.: Subjects comprised 22 patients. Gradients sensitivity were calculated for "squares" in patient's 24-2/30-2 results, so that edges scotomata could be identified where gradients steep. Next, 10 new placed these locations each patient. Each was then measured using this novel grid (52...

Purpose: To compare structure-function relationships based on the Drasdo and Sjöstrand retinal ganglion cell displacement models. Methods: Single eyes from 305 patients with glaucoma 55 heathy participants were included in this multicenter, cross-sectional study. The inner plexiform layer (GCIPL) thickness was measured using spectral domain optical coherence tomography. Visual field measurements performed Humphrey 10-2 test. All A-scan pixels (128 × 512 pixels) allocated to closest location...

Aims To compare the retinal nerve fiber layer thickness (RNFLT) parameters obtained with newly introduced GDx enhanced corneal compensation (ECC) and those variable (VCC) to evaluate their reproducibility correspondence visual field damage (VFD) in total or sectorized fields association refractive errors open-angle glaucoma (OAG) patients. Patients Methods Measurement was assessed 30 normal OAG eyes. Correlation between RNFLT corresponding VFD evaluated 58 Results All of both VCC ECC showed...

In the treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced gastric or gastroesophageal junction cancer, it has been reported that combination trastuzumab with capecitabine plus cisplatin, 5-fluorouracil (5-FU) significantly increased overall survival compared chemotherapy alone (ToGA trial). addition, adjuvant therapy oxaliplatin (XELOX) improved patients who received curative D2 gastrectomy (CLASSIC However, efficacy XELOX for HER2-positive cancer remains unknown....