A5011263502- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Diet and metabolism studies
- Silicone and Siloxane Chemistry
- Cerebral Venous Sinus Thrombosis
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Diet, Metabolism, and Disease
- Intraoperative Neuromonitoring and Anesthetic Effects
- Retinal and Optic Conditions
- Transactional Analysis in Psychotherapy
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Polyoxometalates: Synthesis and Applications
- Personality Disorders and Psychopathology
- Ocular and Laser Science Research
- Bacteriophages and microbial interactions
- Proteoglycans and glycosaminoglycans research
- Sleep and related disorders
- Colorectal and Anal Carcinomas
- Nutritional Studies and Diet
The University of Tokyo
2009-2025
Osaka University
2020-2023
University of Tokyo Hospital
2015-2022
Yotsuya Medical Cube
2022
Kanto Central Hospital
2012-2020
Fujifilm (Japan)
2015-2020
Tokyo University of Social Welfare
2012-2019
Ophthalmology Associates (United States)
2019
Nihon University
2019
University of Tsukuba
2015
Purpose.: To identify sex-related differences and age-related changes in individual retinal layer thicknesses a population of healthy eyes across the lifespan, using spectral domain optical coherence tomography (SD-OCT). Methods.: In seven institutes Japan, mean nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), nuclear (INL), outer (OPL), (ONL), photoreceptor segment (IS), (OS) were measured SD-OCT with new automated segmentation protocol 256 subjects. Results.: Interoperator...
Purpose.: To demonstrate the three-dimensional macular thickness distribution in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate its association with sex, age, axial length. Methods.: Mean regional retinal measurements on Early Treatment Diabetic Retinopathy Study (ETDRS) layout were obtained raster scanning (6 × 6 mm) using SD-OCT 248 eyes of Japanese subjects. Results.: foveal was 222 ± 19 μm; it significantly greater men (226 μm) than women (218 18 P...
<h3>Objectives</h3> To evaluate the peripapillary distribution of retinal nerve fiber layer thickness (RNFLT) in normal eyes using spectral-domain optical coherence tomography and to study potentially related factors. <h3>Methods</h3> In 7 institutes Japan, RNFLT concentric circles with diameters ranging from 2.2 4.0 mm were measured 251 ophthalmologically subjects. Multiple regression analysis for association sex, age, axial length, disc area was performed. <h3>Results</h3> Retinal...
Background: Dementia and its first or transitional stage, mild cognitive impairment (MCI), is a major concern for the aging Japanese society. Thus, use of dietary supplements to improve maintain function has become topic public interest. Objective: In this study, we evaluated effects composite supplement containing food-derived antioxidants, specifically astaxanthin sesamin (AS), on in people with MCI. Method: Twenty-one healthy participants MCI were recruited our double-blind...
A ketogenic diet is expected to be an effective support therapy for patients with cancer, but the degree and duration of carbohydrate restriction are unclear. We performed a case series study new regimen in different types stage IV cancer. Carbohydrates were restricted 10 g/day during week one, 20 from two three months, 30 thereafter. total 55 participated study, data 37 administered months analyzed. No severe adverse events associated observed. Total ketone bodies increased significantly,...
Scope Zinc is an essential mineral that plays important role in the body. We previously reported orally feeding zinc‐enriched yeast to mice induces nonrapid‐eye‐movement sleep. In addition, astaxanthin, antioxidant abundant seafood such as salmon and krill, able chelate minerals may promote zinc absorption, which return also improve The purpose of our study was examine effect zinc‐rich astaxanthin‐containing food on sleep humans. Methods results conducted a randomized, double‐blinded,...
PurposeTo elucidate which swept source-optical coherence tomography (SS-OCT) derived optic nerve head (ONH) parameters are associated with longer axial length (AXL) in healthy myopic eyes.DesignProspective cross-sectional observational studyMethodsTwo hundred eleven eyes of 140 subjects {96 Emmetropic-mild (AXL: 22.2 - 24.5 mm), 83 moderately (24.5 26.0 mm) and 32 highly (26.0 – 27.4 eyes} were enrolled. Bruch's membrane opening (BMO), anterior scleral canal (ASCO) area ovality, minimum rim...
A multicenter cross-sectional study was conducted to investigate the magnification-corrected association between fovea-disc distance (FDD) and optical coherence tomography (OCT)-measured macular retinal layer thickness in eyes with without primary open-angle glaucoma (POAG). 12.0 × 9.0-mm-wide swept-source OCT scan, which includes both macula optic disc, performed 190 from 124 healthy subjects (normal group) 149 117 POAG patients (POAG group). The FDD of nerve fiber (mRNFL), ganglion cell...
To investigate the influence of glaucoma and myopia on cross-sectional configuration β-zone peripapillary atrophy (PPA-β) using spectral-domain optical coherence tomography (SD-OCT).Cross-sectional B-scan images PPA-β obtained with SD-OCT were evaluated in 100 eyes consecutive patients POAG, regardless intraocular pressure level, normal subjects. PPA bed configurations classified, associated factors studied multivariate analysis.In 147 (84 POAG 63 eyes; P = 0.0012), was composed straight (14...
Several studies have reported that short sleep duration is a risk factor for obesity and metabolic disease. Moreover, both timing might independently be associated with dietary nutrient intake. In this study, we investigated the associations between self-reported intake, without adjustments variations in (i.e., midpoint of sleep). We conducted questionnaire survey, comprising validated brief self-administered diet history (BDHQ) Japanese version Pittsburgh Sleep Quality Index (PSQI) among...
The purpose of this study was to describe the clinicopathologic features malignant transformation in patients with ovarian endometrioma, their treatment and outcome Kinki region, Japan.Patients meeting Sampson Scott's criteria for cancer associated endometriosis were identified by chart review pathology reports. This retrospective survey describes 18 women a history endometrioma. These cases followed as benign endometrioma before on basis imaging findings gynecologic oncologists or...
To evaluate the cross-sectional configurations of peripapillary atrophy (PPA)-alpha and -beta in ophthalmologically normal subjects using spectral domain-optical coherence tomography (SD-OCT).One hundred twenty had a complete ophthalmic examination including axial length measurement, standard automated perimetry, fundus imaging with photography, SD-OCT (3D OCT-1000; Topcon Inc., Tokyo, Japan). PPA-alpha were identified color photographs optic disc. Cross-sectional B-mode images retina...
Purpose.: We investigated the correlation between 24-hour IOP in habitual (sitting during day and supine night) position (H24h-IOP) after a postural-change test (PCT-IOP) water-drinking (WDT-IOP). also ocular systemic factors related with them patients normal tension glaucoma (NTG). Methods.: Japanese NTG underwent H24h-IOP, PCT-IOP, WDT-IOP measurements period. Correlations among WDT-IOP, contributing ocular/systemic were using regression analysis. Results.: There 33 included. Peak H24h-IOP...
Blepharitis was the most common side effect leading to discontinuation of ripasudil therapy. Prior allergic reactions other topical glaucoma were found be a risk factor for ripasudil-induced blepharitis.To report incidence proportion blepharitis and its relating factors due long-term use 0.4% riapasudil, Rho-kinase inhibitor, in patients clinical setting.One hundred three eyes 103 consecutive who started treatment between December 2014 February 2017 at our institute, had follow-up period...
A ketogenic diet has been proposed as a potential supportive therapy for cancer patients, although its long-term influence on survival rates remain controversial. In our previous report, we presented promising results 37 of 55 patients with advanced enrolled between 2013 and 2018 who remained at least 3 months. We followed all until March 2023 analyzed the data up to 2022. For previously reported results, median follow-up period was 25 (range 3–104) months 28 died. The overall (OS) in this...
To explore the effects of deep optic nerve head (ONH) structures on Bruch's membrane opening (BMO)-minimum rim width (MRW) and peripapillary retinal fiber layer thickness (pRNFLT) in healthy eyes.
The renin-angiotensin-aldosterone system is implicated in the pathogenesis of heart failure. Pharmacological blockade angiotensin II (Ang II)-dependent signaling clinically effective reducing cardiovascular events after myocardial infarction (MI) but still fails to completely prevent remodeling. molecular basis underlying this Ang II-independent remodeling unclear.Acute MI was induced by coronary ligation wild-type (WT) and type IA receptor-knockout (AT1A-KO) mice. Left ventricular (LV)...
Background We propose a new play activity intervention program for mothers and children. Our interdisciplinary integrates four fields of child-related sciences: neuroscience, preschool pedagogy, developmental psychology, child maternal psychiatry. To determine the effect this on mother psychosocial problems related to parenting stress children's cognitive abilities, we performed cluster randomized controlled trial. Methodology/Principal Findings Participants were 238 pairs typically...