A5101459274- Dermatology and Skin Diseases
- Advanced MRI Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Allergic Rhinitis and Sensitization
- Advanced MEMS and NEMS Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Conducting polymers and applications
- Electrowetting and Microfluidic Technologies
- Asthma and respiratory diseases
- Organic Electronics and Photovoltaics
- Tea Polyphenols and Effects
- Microfluidic and Bio-sensing Technologies
- Natural Antidiabetic Agents Studies
- Plasma Diagnostics and Applications
- Particle accelerators and beam dynamics
- Advanced NMR Techniques and Applications
- Quantum Computing Algorithms and Architecture
- Sinusitis and nasal conditions
- Photonic and Optical Devices
- Force Microscopy Techniques and Applications
- Nanofabrication and Lithography Techniques
- Phytochemicals and Antioxidant Activities
- Advanced machining processes and optimization
- Mechanical and Optical Resonators
- Railway Engineering and Dynamics
Japanese Red Cross Society Kyoto Daini Hospital
2020-2024
Canon (Japan)
2018-2024
Canon Medical Systems Corporation (Japan)
2018-2024
Sanofi (Japan)
2018-2024
Saiseikai Ibaraki Hospital
2024
Sanofi (Mexico)
2021-2022
Railway Technical Research Institute
2018-2022
Tokyo City University
2022
Quality Electrodynamics (United States)
2008-2021
Tokyo Institute of Technology
2010-2020
Abstract Background The human monoclonal antibody dupilumab blocks interleukin (IL)‐4 andIL‐13, key and central drivers of type 2 inflammation. Dupilumab, on background mometasone furoate nasal spray (MFNS), improved outcomes in the phase III SINUS‐52 study (NCT02898454) patients with severe chronic rhinosinusitis polyps (CRSwNP). This posthoc analysis examined whether eosinophilic status CRSwNP was a predictor efficacy. Methods Patients were randomized 1:1:1 to 300 mg every weeks (q2w)...
The antiobesity effects of Chinese black tea (Pu‐erh tea) and gallic acid (GA) were investigated using in vitro vivo assays. extract (BTE) GA inhibited pancreatic lipase activity a dose‐dependent manner ; the IC(inhibitory concentration) 50 values 101.6 9.2 µg/mL, respectively. Black (50, 100 mg/kg body weight (b.w.)) (15, 45 b.w.) significantly suppressed elevation blood triglyceride after oral administration corn oil emulsion (8 mL oil/kg to male ddY mice. Moreover, BTE also evaluated...
Although growth differentiation factor-5 (GDF5) has been implicated in skeletal development and joint morphogenesis mammals, little is known about its functionality adipogenesis energy homeostasis. Here, we show a critical role of GDF5 regulating brown for systemic expenditure mice. expression was preferentially upregulated adipose tissues from inborn acquired obesity Transgenic overexpression led to lean phenotype reduced susceptibility diet-induced through increased expenditure....
Objectives/Hypothesis Dupilumab, which blocks the shared receptor component for interleukin‐4 and interleukin‐13, reduced polyp size, sinus opacification, symptom severity, was well tolerated in patients with chronic rhinosinusitis nasal polyps (CRSwNP) SINUS‐52 study (NCT02898454). We assessed dupilumab enrolled at Japanese centers. Methods Patients on a background of mometasone furoate spray, received 300 mg every 2 weeks (q2w) 52 (Arm A); q2w 24 weeks, followed by 4 (q4w) 28 B); or...
Zinc ions (Zn2+) are vital to most cells, with the intracellular concentrations of Zn2+ being tightly regulated by multiple zinc transporters located at plasma and organelle membranes. We herein present 2.2-3.1 Å-resolution cryo-EM structures a Golgi-localized human Zn2+/H+ antiporter ZnT7 (hZnT7) in Zn2+-bound unbound forms. Cryo-EM analyses show that hZnT7 exists as dimer via tight interactions both cytosolic transmembrane (TM) domains two protomers, each which contains single Zn2+-binding...
The radiofrequency (RF) receive array coil is a complicated device with many inductors and capacitors serves as one of the most critical magnetic resonance imaging (MRI) electronic devices. It directly determines achievable level signal-to-noise ratio (SNR). Simply put, however, RF nothing but an LC circuit. was first proposed more than 20 years ago, evolving from simple arrangement few channels to system 128 channels, enabling highly sophisticated parallel imaging, at different field...
The purpose of this study was to describe the clinicopathologic features malignant transformation in patients with ovarian endometrioma, their treatment and outcome Kinki region, Japan.Patients meeting Sampson Scott's criteria for cancer associated endometriosis were identified by chart review pathology reports. This retrospective survey describes 18 women a history endometrioma. These cases followed as benign endometrioma before on basis imaging findings gynecologic oncologists or...
Poly(3-hexylthiophene) (P3HT) with a bromobutyl functional group at the ω-chain-end (P3HT-C4Br) and P3HT groups α,ω-chain-ends (BrC4-P3HT-C4Br) were synthesized by selecting appropriate initiators for Grignard metathesis (GRIM) polymerization. The high end-functionality was confirmed matrix assisted laser desorption-ionization time-of-flight (MALDI–TOF) mass spectrometry. These polymers efficiently reacted living anionic of 4-(4′-N,N-dihexylaminophenylethynyl)styrene (DHPS) to yield novel...
The P3HT:PCBM (P3HT = poly(3-hexylthiophene, PCBM phenyl-C61-butyric acid methyl ester) bulk-heterojunction (BHJ) organic photovoltaic (OPV) cells using the AB diblock and ABA triblock copolymers (A polystyrene derivative with donor-acceptor units (PTCNE) B P3HT) as compatibilizers were fabricated. Under optimized blend ratio of block copolymer, power conversion efficiency (PCE) was enhanced. This PCE enhancement clearly related to increased short-circuit current (J(sc)) fill factor (FF)....
BackgroundDupilumab, a human monoclonal antibody, blocks the shared receptor unit for interleukin‐4 and interleukin‐13. International phase II III studies have evaluated efficacy safety of dupilumab in adults with moderate‐to‐severe atopic dermatitis (AD), but effects Japanese patients not been reported.
Abstract The real‐world evidence on the profiles of patients suffering from atopic dermatitis ( AD ) in Japan is sparse. A retrospective claim database analysis was conducted to estimate health‐care resource use HCRU and current treatment. Data October 2013 September 2016 were extracted JMDC (Tokyo, Japan) claims database. assessed by a comparison matched non‐ controls. multivariate performed attributable . n = 39 893) have more certain diagnoses such as rhinitis, viral fungal infections,...
Abstract Purpose: To compare a new birdcage‐transmit, 28‐channel receive array (28‐Ch) coil and quadrature volume for 7T morphologic MRI T2 mapping of knee cartilage. Materials Methods: The right knees 10 healthy subjects were imaged on whole body magnetic resonance (MR) scanner using both coils. 3D fast low‐angle shot (3D‐FLASH) multiecho spin‐echo (MESE) sequences implemented. Cartilage signal‐to‐noise ratio (SNR), contrast‐to‐noise (CNR), thickness, values assessed. Results: SNR/CNR was...
Prurigo nodularis (PN) is a chronic inflammatory skin disorder with high disease burden. In this cross-sectional, web-based survey, Global Questions (GQ), the Numerical Rating Scales (NRS) for pruritus, burning sensation and sleep disturbance, Short-Form-8 (SF-8) Health Survey, Dermatology Life Quality Index (DLQI), Patient Questionnaire 9 (PHQ-9), Work Productivity Activity Impairment (WPAI), Treatment Satisfaction Medication-9 (TSQM-9) scores were used to assess current burden treatment...
Background: Recently, biologic agents administered as a subcutaneous injection have been introduced treatment options for atopic dermatitis (AD). Biologic treatments differ considerably from traditional topical and systemic anti-inflammatory treatments, it is unclear how this may impact patient physician preferences treatments.Objective: To examine the new of patients physicians.Methods: Discrete choice experiment methodology was used to quantify via an online survey. Participants were...
Poly(3-hexylthiophene) (P3HT)-segment-based block copolymers have been reported to deliver an effective compatibilizer function in the P3HT:PC61BM bulk-heterojunction (BHJ) system simultaneously improve performance and stability. However, as limited by deficient optophysic properties of system, resultant power conversion efficiency (PCE) compatibilizer-mediated devices is low despite optimized chemical structures P3HT-segment-based copolymers. To better shed light on such a effect, herein...