A5090181313- Sesame and Sesamin Research
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Phytoestrogen effects and research
- Sleep and related disorders
- Systemic Lupus Erythematosus Research
- Optical Coherence Tomography Applications
- Biochemical effects in animals
- Ophthalmology and Eye Disorders
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Migraine and Headache Studies
- Advanced Glycation End Products research
- Trace Elements in Health
- Rheumatoid Arthritis Research and Therapies
- Hereditary Neurological Disorders
- Alzheimer's disease research and treatments
- Cytokine Signaling Pathways and Interactions
- Antioxidant Activity and Oxidative Stress
- Ginkgo biloba and Cashew Applications
- Exercise and Physiological Responses
- Ocular Diseases and Behçet’s Syndrome
- Genomics, phytochemicals, and oxidative stress
- Animal Nutrition and Physiology
- Ocular Surface and Contact Lens
Suntory Foundation for Life Sciences
2019-2024
Kanazawa University
2017-2023
Keio University
2020
Suntory (Japan)
2015
Nagoya University
2005
Tight junction (TJ)-like structures have been reported in Schwann cells, but their molecular composition and physiological function remain elusive. We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules epithelia), constituted these structures. Claudin-19-deficient mice were generated, they exhibited behavioral abnormalities could be attributed to peripheral nervous system deficits. Electrophysiological analyses showed claudin-19 deficiency affected nerve...
A multicenter cross-sectional study was conducted to investigate the magnification-corrected association between fovea-disc distance (FDD) and optical coherence tomography (OCT)-measured macular retinal layer thickness in eyes with without primary open-angle glaucoma (POAG). 12.0 × 9.0-mm-wide swept-source OCT scan, which includes both macula optic disc, performed 190 from 124 healthy subjects (normal group) 149 117 POAG patients (POAG group). The FDD of nerve fiber (mRNFL), ganglion cell...
What is the central question of this study? Our aim was to examine whether sesamin can prevent a decline in exercise capacity high-fat diet-induced diabetic mice. hypothesis that maintenance mitochondrial function and attenuation oxidative stress skeletal muscle would contribute result. main finding its importance? The new findings are prevents diabetes-induced decrease impairment through inhibition NAD(P)H oxidase-dependent muscle. Sesamin may be useful as novel agent for treatment diabetes...
Sesame lignans, which are biologically active compounds present in sesame seeds and oil, known to have neuroprotective effects several models of brain dysfunction. However, the lignans on age-related dysfunction not clear were thus investigated study using a senescence-accelerated mouse (SAMP10). Two-month-old male SAMP10 mice administrated basal diet with 0% or 0.05% for two months, 0%, 0.02%, 10 months subjected step-through passive avoidance tasks forced swim tests. Reactive carbonyl...
Sesamin has anti-oxidative functions in vivo. Fatigue is caused part by oxidative stress. We evaluated whether sesame lignans (sesamin/episesamin=1/1, 10 mg) with vitamin E (55 mg of alpha-tocopherol) (SVE) could improve subjective statuses and capacity humans using questionnaires on fatigue, sleep physical appearance, as well low-density lipoprotein oxidation lag time. A placebo-controlled, double-blind, parallel-group study was conducted subjects experiencing daily fatigue. After a run-in...
Sesamin is a major lignan constituent of sesame and possesses various health-promoting effects. Previous studies have demonstrated that sesamin extends the lifespan Drosophila Caenorhabditis elegans corrects oxidative damage-related tissue dysfunction in mammals. To understand its anti-aging effects, we aimed to determine whether restores function hampered by damage suppresses several aging-related phenotypes using senescence-accelerated models.We elucidated effects on muscle, brain midgut...
To investigate the effect of trabeculectomy on waveform changes laser speckle flowgraphy (LSFG) in optic nerve head (ONH) patients with glaucoma.Forty-eight eyes 48 open angle glaucoma were included this prospective study. LSFG was performed before and 1, 3, 6 months after trabeculectomy. Longitudinal average mean blur rate (MBR), blow out score (BOS), resistivity index (RI), falling rate, skew, acceleration time index, tissue area ONH analyzed by using mixed-effects models.Intraocular...
Sesamin, a representative sesame lignan, has health-promoting activities. Sesamin is converted into catechol derivatives and further their glucuronides or sulfates in vivo, whereas the biological activities of sesamin metabolites remain unclear. We examined inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production mouse macrophage-like J774.1 cells found that monocatechol derivative SC1, (7α,7′α,8α,8′α)-3,4-dihydroxy-3′,4′-methylenedioxy-7,9′:7′,9-diepoxylignane,...
Abstract Sesamin [(7α,7′α,8α,8′α)-3,4:3′,4′-bis(methylenedioxy)-7,9′:7′,9-diepoxylignane] is a major lignan in sesame seeds. converted to the catechol metabolite, SC1 [(7α,7′α,8α,8′α)-3′,4′-methylenedioxy-7,9′:7′,9-diepoxylignane-3,4-diol] with anti-inflammatory effects after oral administration. However, its molecular target remains unknown. Analysis using high-performance affinity nanobeads led identification of annexin A1 (ANX A1) as an SC1-binding protein. was found bind repeat 3 region...
Beneficial effects of sesame lignans, especially antioxidative effects, have been widely reported; however, its potential on autonomic nerves not yet investigated. Therefore, the current study aimed to investigate effect lignans nervous system. The sympathetic nerve activity in rat skeletal muscle was measured using electrophysiological approaches, with blood flow determined laser Doppler method. Sesame were administered intragastrically at 2 and 20 mg/kg, after 60 min, observed increase by...
Recurrent painful ophthalmoplegic neuropathy (RPON) is a rare disorder, which typically occurs in children, and causes headaches unilateral oculomotor palsy. Early high-dose corticosteroid therapy recommended to rapidly resolve acute episodes. However, the pathophysiology therapeutic options for this disorder remain be fully elucidated. We report case with typical clinical features of RPON successfully treated beta-blocker eye drop instillation after effects other therapies were not...
We conducted a prospective study in patients with normal-tension glaucoma (NTG) who received either isopropyl unoprostone or latanoprost. compared the drugs terms of their effects on intraocular pressure (IOP) and visual field loss progression over 3-year period.Prospective, randomized controlled study.We enrolled 48 newly diagnosed NTG at Kanazawa University Hospital. Eligible were randomly allocated (1:1) to receive latanoprost ophthalmic solutions. The primary outcomes IOP changes...
Sesamin is a functional ingredient in sesame (Sesamum indicum) seeds and has many physiological effects. This study investigated whether lignans, sesamin episesamin (1:1), can suppress age-related disorders of the kidney.Twenty-month-old mice were divided into three groups, each group received regular diet (O-C), containing lignans (O-SE), α-tocopherol (VE; O-SE+VE), respectively, for 5 months. Six-month-old young (Y-C) compared to older mice.Renal lipofuscin deposition was increased O-C...
Male C57BL/6J (B6) mice aged 24 weeks were provided two concentrations (1.5 or 3.0 g/L) of quercetin glycosides (QG) in drinking water over the subsequent weeks. The objective was to determine if QG could improve motor function during early stages aging. No sustained significant differences body composition food intake noted confirm safety treatment. Treated had significantly improved performance grip strength and rotarod tests but not treadmill performance. functional benefits reflected...
Purpose: We assessed the ability to detect preperimetric glaucoma (PPG) based on asymmetry in thickness of macular inner retinal layers measured by spectral-domain optical coherence tomography. Methods: studied 45 normal eyes and 50 PPG retrospectively. Three-dimensional tomography area scans were used obtain nerve fiber layer (RNFL), ganglion cell layer/inner plexiform (GCL/IPL), complex (GCC). calculated differences between upper lower hemispheres for corresponding superpixels, then...
Background/Objectives: Circadian clocks are endogenous systems that regulate numerous biological, physiological, and behavioral events in living organisms. Aging attenuates the precision robustness of circadian clocks, leading to prolonged dampened gene oscillation rhythms amplitudes. This study investigated effects food-derived polyphenols such as ellagic acid its metabolites (urolithin A, B, C) on aging clock at cellular level using senescent human fibroblast cells, TIG-3 cells. Methods:...
Cellular senescence induces inflammation and is now considered one of the causes organismal aging. Accumulating evidence indicates that age-related deterioration mitochondrial function leads to an increase in reactive oxygen species (ROS) DNA damage, which turn cellular senescence. Thus, it important maintain suppress oxidative stress order inhibit accumulation senescent cells. Sesamin its isomer episesamin are types lignans found sesame oil, after being metabolized liver, their metabolites...
<h3>Background</h3> Janus kinase 3 (JAK3) plays a critical role in gamma-chain cytokine signal transduction and is essential for activation of lymphocytes. Interferon signaling dependent on other family members, but not JAK3, an important component immune response to infectious agents. VX-509 selectively inhibits JAK3 improves signs symptoms patients with rheumatoid arthritis (RA). <h3>Objectives</h3> To evaluate the in-vivo pharmacodynamic effects treatment systemic markers RA disease state...
Abstract Purpose Optical coherence tomography (OCT) is a useful tool for predicting visual recovery after the removal of pituitary tumors. However, utility OCT in patients with tumors and normal field unclear. We aimed to analyze features without defects. Methods Pituitary defects were selected. A total 138 eyes from 69 patients, assessed by Humphrey test OCT, enrolled this study. Using preoperative coronal sections MR images, divided into chiasmal compression (CC) non-chiasmal (non-CC)...