A5018114844- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Horticultural and Viticultural Research
- PI3K/AKT/mTOR signaling in cancer
- Bone Metabolism and Diseases
- Sesame and Sesamin Research
- Polyamine Metabolism and Applications
- Hydrogen's biological and therapeutic effects
- Vitamin C and Antioxidants Research
- Cellular transport and secretion
- Quinazolinone synthesis and applications
- Plant biochemistry and biosynthesis
- Photosynthetic Processes and Mechanisms
- Phagocytosis and Immune Regulation
- IL-33, ST2, and ILC Pathways
- Moringa oleifera research and applications
- Autophagy in Disease and Therapy
- Plant Micronutrient Interactions and Effects
- Ginger and Zingiberaceae research
- Lipid Membrane Structure and Behavior
- Advanced Glycation End Products research
- Fungal and yeast genetics research
- Plant Pathogens and Fungal Diseases
- Powdery Mildew Fungal Diseases
- Fermentation and Sensory Analysis
Yamagata University
2023-2025
Okayama University
2017-2022
Tokushima University
2017-2022
Downy mildew (DM), caused by Plasmopara viticola, is one of the most serious grapevine diseases. Resistant grapevines are a well-known tool for mitigating pathogen-caused damage. We evaluated 29 global cultivars from 7 species sensitivity to P. viticola. Chardonnay belonging sensitive V. vinifera and Qingdahean resistant riparia were chosen further investigation on resistance mechanism against DM. Unlike Chardonnay, exerted an inhibitory effect stomatal targeting, suppression closure,...
Nitrogen, an indispensable macronutrient, significantly affects the appearance, quality, and yield of grapes (Vitis vinifera). Adequate nitrate uptake intracellular transport, facilitated primarily by transport (NRT) proteins, are crucial for maintaining nutritional balance. However, there no reports on NRT gene family in grapes. In this study, we identified 53 Nitrate Transporter 1/Peptide Family (NPF), 3 transporter 2 (NRT2), 1 Assimilation-Related (NAR2) genes grapevine Pinot Noir PN40024...
Golgins are a family of Golgi-localized long coiled-coil proteins. The major golgin function is thought to be the tethering vesicles, membranes, and cytoskeletal elements Golgi. We previously showed that knockdown one longest golgins, Giantin, altered glycosylation patterns cell surfaces kinetics cargo transport, suggesting Giantin maintains correct through slowing down transport within also sizes numbers mini Golgi stacks generated by microtubule de-polymerization, it independence...
The process of apoptotic cell clearance by phagocytes, known as efferocytosis, plays an essential role in maintaining homeostasis. Defects efferocytosis can lead to inflammatory diseases such atherosclerosis and autoimmune disorders. Therefore, the maintenance promotion are considered crucial for preventing these diseases. In this study, we observed that resveratrol, a representative functional food ingredient, its glycoside, piceid, promoted both human THP-1 macrophages differentiated with...
Sesamin, a representative sesame lignan, has health-promoting activities. Sesamin is converted into catechol derivatives and further their glucuronides or sulfates in vivo, whereas the biological activities of sesamin metabolites remain unclear. We examined inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production mouse macrophage-like J774.1 cells found that monocatechol derivative SC1, (7α,7′α,8α,8′α)-3,4-dihydroxy-3′,4′-methylenedioxy-7,9′:7′,9-diepoxylignane,...
The regulating role of phosphatidylinositide 3-kinase (PI3K) in benzyl isothiocyanate (BITC)-induced Nrf2 activation, contributing to the inducible expression cytoprotective genes, was investigated. BITC significantly enhanced accumulation as well autophagic molecules human colorectal cancer HCT-116 cells. Experiments using a PI3K-specific inhibitor suggested that PI3K plays key non-canonical activation by BITC.
Benzyl isothiocyanate (BITC) is a naturally-occurring derived from cruciferous vegetables. BITC has been reported to inhibit the proliferation of various cancer cells, which believed be important for inhibition tumorigenesis. However, detailed mechanisms action remain unclear. In this study, we employed budding yeast Saccharomyces cerevisiae as model organism screening. Twelve genes including MTW1 were identified overexpression suppressors antiproliferative effect using genome-wide...
Abstract We investigated the effect of benzyl isothiocyanate (BITC) on hydrogen peroxide‐induced gene expression a T‐helper‐2 cytokine, interleukin (IL)‐13, in T lymphocytic leukemia Jurkat cells. The 24‐h pretreatment BITC significantly inhibited IL‐13 enhanced by peroxide. Although did not change level phosphorylated c‐Jun N‐terminal kinase (JNK), it nuclear translocation induced also increased protein glutathione S ‐transferase (GST) isozymes, GSTP1/2, as well total GST activity. A...
Abstract Benzyl isothiocyanate (BITC), derived from cruciferous vegetables, is an organosulfur compound exerting antiproliferative effects in several human cancer cells. In this study, we assessed BITC as a potential osteoclastogenesis inhibitor and investigated its underlying mechanism. at 5 μM significantly decreased the viability of osteoclast‐like differentiating RAW264.7 cells, coinciding with downregulation primary biomarkers for osteoclast differentiation, such tartrate‐resistant acid...