A5039849972- Polysaccharides and Plant Cell Walls
- Biofuel production and bioconversion
- Food composition and properties
- Enzyme Production and Characterization
- Polysaccharides Composition and Applications
- Microbial Metabolites in Food Biotechnology
- Antioxidant Activity and Oxidative Stress
- Advanced Glycation End Products research
- Phytochemicals and Antioxidant Activities
- Redox biology and oxidative stress
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Semiconductor Quantum Structures and Devices
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Insect and Pesticide Research
- Free Radicals and Antioxidants
- Biochemical effects in animals
- Proteoglycans and glycosaminoglycans research
- Protein Hydrolysis and Bioactive Peptides
- Metabolomics and Mass Spectrometry Studies
- Food Quality and Safety Studies
- Cardiac Ischemia and Reperfusion
- Eicosanoids and Hypertension Pharmacology
- Semiconductor materials and devices
University of Hyogo
2015-2025
Food & Nutrition
2016-2025
Hirosaki University
2011-2024
Memorial Hospital
2024
Thrombosis Research Institute
2018-2019
University College London
2018-2019
National Center for Global Health and Medicine
2012
Tokushima University
2001-2009
Nagoya University
1992-2009
Yao Tokushukai General Hospital
1998-2008
A revised system of abbreviated names is proposed for xyloglucan‐derived oligosaccharides. Each (1→4)‐linked β‐ d ‐glucosyl residue (and the reducing terminal ‐glucose moiety) backbone given a one‐letter code according to its substituents. The name oligosaccharide consists these letters listed in sequence from non‐reducing terminus backbone.
We have previously reported that amyloid Aβ, the major component of senile plaques in Alzheimer's disease (AD), binds Cu with high affinity via histidine and tyrosine residues [Atwood, C. S., et al. (1998) J. Biol. Chem. 273, 12817−12826; Atwood, (2000) Neurochem. 75, 1219−1233] produces H2O2 by catalyzing reduction Cu(II) or Fe(III) [Huang, X., (1999) Biochemistry 38, 7609−7616; Huang, 274, 37111−37116]. Incubation induces SDS-resistant oligomerization Aβ 1219−1233], a feature...
As a preliminary study, we have found that honey from manuka (Leptospermum scoparium) in New Zealand inhibits myeloperoxidase (MPO) activity. In this using chromatographic technique, isolated two active compounds for MPO-inhibition honey. One is methyl syringate (MSYR), and the other was identified as novel glycoside of MSYR, 4-O-β-D-gentiobiose, which has been named "leptosin" after genus Leptospermum . The amount ranged 0.2 to 1.2 μmol/g Leptosin only honeys Oceania region, abundantly...
The objectives of this study were to estimate the structure lipid hydroperoxide-modified lysine residue and prove presence adducts in vivo. reaction hydroperoxide toward moiety was investigated employingN-benzoyl-glycyl-l-lysine (Bz-Gly-Lys) as a model compound Lys residues protein 13-hydroperoxyoctadecadienoic acid (13-HPODE) hydroperoxides. One products, X, isolated from mixture 13-HPODE Bz-Gly-Lys then identified N-benzoyl-glycyl-N ε-(hexanonyl)lysine. To formation N ε-(hexanonyl)lysine,...
Abstract In Parkinson's disease, characteristic pathological features are the cell death of nigrostriatal dopamine neurons and formation Lewy bodies composed oxidized proteins. Mitochondrial dysfunction aggregation abnormal proteins have been proposed to cause changes. However, relation between these two factors remains be clarified. this study, effects mitochondrial on oxidative modification accumulation were analyzed using an inhibitor complex I, rotenone, antibodies against acrolein‐...
Abstract Riboflavin‐sensitized photodynamic modification of collagen led to significant formation cross‐linked molecules. Sodium azide or l,4‐diazabicyclo(2,2,2)octane, which are known be singlet oxygen quenchers, and catalase could not inhibit the modification. Surprisingly, was accelerated in presence superoxide dismutase. The aggregation accompanied by loss tyrosine histidine residues collagen. An inhibitory effect dissolved on observed. Similarly, irradiated inhibited oxygen. Dityrosine...
Myeloperoxidase (MPO), secreted by activated neutrophils and macrophages at the site of inflammation, may be implicated in oxidation protein/lipoprotein during development cardiovascular diseases. Flavonoids have been suggested to act as antioxidative anti-inflammatory agents vivo; however, their molecular actions not yet fully understood. In this study, we examined basis inhibitory effects dietary flavonoids, such quercetin, metabolites on catalytic reaction MPO using a combination...
In this study, we determined the complete nucleotide sequence of mitochondrial genome Japanese pond frog Rana nigromaculata. The length was 17, 804 bp, though not absolute due to variation caused by differing numbers repetitive units in control regions individual frogs. gene content, base composition, and codon usage conformed those typical vertebrate patterns. However, comparison organization between three amphibian species (Rana, Xenopus caecilian) provided evidence that arrangement...
We show that anthocyanins can function as potent inhibitors of the formation nitrated tyrosine in vitro, and clarified how pelargonidin (Pel), which has a mono‐hydroxyl group on B‐ring, scavenge peroxynitrite (ONOO − ) by detection reaction products. Pel was reacted with ONOO , then mixture analyzed using high‐performance liquid chromatography (HPLC). The HPLC analyses showed two novel peaks assumed to be Based instrumental analyses, products were identified p ‐hydroxybenzoic acid...
Tetrahydrocurcumin (THC) is an antioxidative substance which derived from curcumin by hydrogenation. Curcumin the main component of turmeric and responsible for yellow color curried foods. First, LDL a normal human volunteer was incubated in presence antioxidant with 10 μM CuSO4 at 37°C 2 hours. All antioxidants tested (THC, curcumin, probucol, α-tocopherol) dose-dependently (1-10 μM) inhibited oxidative modification LDL. Probucol strongest, followed THC, α-tocopherol, curcumin. Next, order...
We investigated the reactivity of allyl isothiocyanate (AITC) with amino groups under physiological conditions. First, chemical reaction AITC bovine serum albumin (BSA) was investigated. When BSA incubated in a phosphate buffer (pH 7.4), loss Lys residues observed. Second, residue N(alpha)-benzoyl-glycyl-L-lysine (BGK) reacted buffer, and novel peak detected using high performance liquid chromatography (HPLC). The purified identified as AITC-modified BGK N(epsilon)-thiocarbamoyl linkage....
Absorption intensities of two exciton bands in CuCl-CuBr solid solutions, the Z 1,2 and 3 , due to spin-orbit splitting have been measured. In CuBr band has a larger intensity than that but with increasing Cl-doping difference becomes small solution Cu(Br 0.23 Cl 0.77 ), where is zero, very weak compared . The variations are explained well by theory exchange interaction Onodera Toyozawa. system found be suitable example effect appears remarkably.
Leptosperin (methyl syringate-4-O-β-d-gentiobioside) serves as a unique marker for ma̅nuka honey, derived from the plant (Leptospermum scoparium). Despite its importance, biosynthesis pathway of leptosperin remains unreported. This study investigates molecular mechanism formation aglycone, methyl syringate (MSYR), in plants. Methyl syringate-4-O-β-d-glucopyranoside (MSYR-glucose) was identified flower nectar but not honey. MSYR distributed flowers, leaves, branches, and roots plants, while...