A5047877300- Semiconductor materials and devices
- Advancements in Semiconductor Devices and Circuit Design
- Parathyroid Disorders and Treatments
- Integrated Circuits and Semiconductor Failure Analysis
- Vitamin D Research Studies
- Silicon Carbide Semiconductor Technologies
- Magnesium in Health and Disease
- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Genetic Syndromes and Imprinting
- Advancements in Photolithography Techniques
- Silicon and Solar Cell Technologies
- Diet, Metabolism, and Disease
- Ion Transport and Channel Regulation
- Diet and metabolism studies
- Multi-Criteria Decision Making
- Nutrition and Health in Aging
- Ferroelectric and Negative Capacitance Devices
- Liver Disease Diagnosis and Treatment
- Biochemical and Molecular Research
- Nanowire Synthesis and Applications
- Thin-Film Transistor Technologies
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
Panasonic (Japan)
1990-2024
Japan Fine Ceramics Center
2022
Kyoto University
2022
Tokai Gakuen University
2021-2022
Tokushima University
2011-2020
Kobe University
1980-2019
Institute of Biomedical Science
2016-2019
Matsuyama Shinonome College
2016-2017
Hitachi (Japan)
1993-2010
The University of Tokyo
1974-2009
A cDNA was isolated from rat C6 glioma cells by expression cloning which encodes a novel Na+-independent neutral amino acid transporter designated LAT1. For functional in Xenopus oocytes, LAT1 required the heavy chain of 4F2 cell surface antigen (CD98), type II membrane glycoprotein. When co-expressed with chain, transported acids branched or aromatic side chains and did not accept basic acidic acids. The transport via sensitive to system L-specific inhibitor...
Abstract The effect of a T-C transition polymorphism at the translation initiation codon human vitamin D receptor (VDR) gene on biological function encoded protein was investigated. Of 239 Japanese women volunteers subjected to genotype analysis for this polymorphism, 32 (13%) were MM (the M allele is ATG putative start site), 75 (31%) mm m ACG and 132 (55%) Mm. bone mineral density (BMD) in lumbar spine (L2–L4) determined 110 healthy premenopausal from shown be 12.0% greater (p <...
An empirical model for device degradation due to hot-carrier injection in submicron n-channel MOSFET's is presented. Relationships between degradation, drain voltage, and substrate current are clarified on the basis of experiments modeling. The presented makes it possible predict lifetime devices by determining a certain criterion, such as taking V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</inf> shift 10 mV over ten years being...
We have isolated a cDNA from rat small intestine that encodes novel Na+-independent neutral amino acid transporter with distinctive characteristics in substrate selectivity and transport property. The encoded protein, designated L-type transporter-2 (LAT-2), shows sequence similarity to the system L LAT-1 (Kanai, Y., Segawa, H., Miyamoto, K., Uchino, Takeda, E., Endou, H. (1998) J. Biol. Chem. 273, 23629-23632) (50% identity) y+L transporters y+LAT-1 (47%) KIAA0245/y+LAT-2 (45%) (Torrents,...
The vitamin D receptor (VDR) is known to mediate the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 through its ability modulate expression target genes. regulation this ligand-activated cellular transcription factor reported occur at both transcriptional and posttranslational levels. To begin address molecular basis by which VDR gene regulated transcriptionally, we report here an initial characterization human promoter. We isolated several overlapping λ-phage cosmid clones that...
Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well patients with chronic kidney disease, but the mechanisms underlying this are not completely understood. To determine whether postprandial hyperphosphatemia promote endothelial dysfunction, we investigated acute effect of loading on function vitro and vivo. Exposing bovine aortic cells to a load increased production reactive oxygen species, which depended influx via sodium-dependent phosphate...
Abstract The major physiological activity of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] is the regulation calcium absorption in small intestine, and level vitamin D receptor (VDR) an important factor this regulation. In a previous study, we indicated that caudal-related homeodomain Cdx-2 played role intestine-specific transcription human VDR gene. polymorphism was identified core sequence 5′-ATAAAAACTTAT-3′ binding site gene promoter. 261 Japanese women with genotyped polymorphisms, 48 were...
A fully depleted lean channel transistor (DELTA) having a gate structure and vertical ultrathin SOI (silicon-on-insulator) with selective field oxide is reported. In the deep submicron region, oxidation useful for achieving isolation. It provides high-quality crystal Si-SiO/sub 2/ interface as good those of conventional bulk single-crystal devices. Using experiments simulation, it was shown that DELTA has effective controllability its (<0.2- mu m) superior device characteristics, e.g....
Low-voltage circuit technologies for higher-density dynamic RAMs (DRAMs) and their application to an experimental 64-Mb DRAM with a 1.5-V internal operating voltage are presented. A complementary current sensing scheme is proposed reduce data transmission delay. speed improvement of 20 ns was achieved when utilizing power supply. An accurate speed-enhanced half-V/sub CC/ generator current-mirror amplifier tri-state buffer proposed. With it, response time reduction about 1.5 decades realized....
Drain avalanche hot-carrier (DAHC) injection, which imposes the most severe limitations on n-channel MOS device design, is investigated from viewpoint of surface-state generation and its localized area in channel. It shown, using charge pumping technique, that surface states are mainly created by hot-hole small degraded stretches toward source region with increased stress time. A remarkable correlation between increase density, transconductance degradation, substrate current also described....
This paper reports on investigation of channel hot-carrier generation for various device structures. The dependences MOSFET structure are characterized by measuring the gate current and substrate as low order 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-15</sup> A. measured due to hot-electron injection into oxide is modeled numerically thermionic emission from heated electron gas over Si-SiO <inf...
We identified an amino acid transporter that is associated with the cystinuria-related type II membrane glycoprotein, rBAT (related to b<sup>0,+</sup> transporter). The designated BAT1 (b<sup>0,+</sup>-type 1) from rat kidney was found be structurally related recently transporters for system L, y<sup>+</sup>L, and x<sup>−</sup>C, which are linked, via a disulfide bond, other 4F2hc (4F2 heavy chain). In nonreducing condition, 125-kDa band, seems correspond heterodimeric complex of rBAT,...
In a study of the rat intestinal P(i) transport system, an activator protein for Na/P(i) co-transport system (PiUS) was isolated and characterized. We also investigated effects restriction vitamin D (two most important physiological pathophysiological regulators absorption in small intestine) on activity expression co-transporters that are expressed intestine. Rat PiUS encodes 424-residue with calculated molecular mass 51463 Da. The microinjection into Xenopus oocytes markedly stimulated...
Abstract The actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) are mediated through the nuclear vitamin D receptor (VDR). regulation VDR abundance plays an important role in determining magnitude target cell response to 1,25(OH)2D3. major physiological activity 1,25(OH)2D3 is calcium absorption small intestine, and level factor this regulation. However, characterization gene expression intestine remains unknown. In present study, we investigated human (hVDR) intestine. 4.0 kb 5′-flanking...
Reactive oxygen species, generated by reduction-oxidation (redox) reactions, have been recognized as one of the major mediators ischemia and reperfusion injury in brain. species-induced cerebral events are attributable, part, to change intracellular signaling molecules including mitogen-activated protein (MAP) kinases. Big MAP kinase 1 (BMK1), also known ERK5, is a newly identified member family has reported be sensitive oxidative stress. In present study, we examined effect...
Deviation in device characteristics due to mechanical stress is investigated experimentally and analytically from the viewpoints of scaling hot-carrier effects. A analysis program, SIMUS (stress program for multilayer structure) 2D/F, which can analyze state thin structures such as LSI devices throughout their manufacturing process, was used. In scaled MOS devices, effect uniaxial reduced. However, vertical stress, mold becomes a serious problem when causes compressive surface stress....