A5020382541- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Vibrio bacteria research studies
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Muscle metabolism and nutrition
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Aquaculture disease management and microbiota
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Nutrition and Health in Aging
- Cholesterol and Lipid Metabolism
- Diabetes and associated disorders
- Antibiotic Resistance in Bacteria
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Aldose Reductase and Taurine
- Protein Kinase Regulation and GTPase Signaling
- Cardiac Ischemia and Reperfusion
- Biochemical effects in animals
University of Shimane
2018-2024
Tokushima University
2011-2021
RELX Group (Netherlands)
2021
Institute of Biomedical Science
2015-2018
The University of Tokyo
2009
Hiroshima University
2009
Tokushima University Hospital
2008
Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well patients with chronic kidney disease, but the mechanisms underlying this are not completely understood. To determine whether postprandial hyperphosphatemia promote endothelial dysfunction, we investigated acute effect of loading on function vitro and vivo. Exposing bovine aortic cells to a load increased production reactive oxygen species, which depended influx via sodium-dependent phosphate...
Fibroblast growth factor 21 (FGF21) has recently emerged as a metabolic hormone involved in regulating glucose and lipid metabolism mouse, but the regulatory mechanisms actions of FGF21 humans remain unclear. Here we have investigated human gene at transcriptional level. A deletion study promoter (−1672 to +230 bp) revealed two fasting signals, including peroxisome proliferator-activated receptor α (PPARα) glucagon that independently induced transcription mouse primary hepatocytes. In...
Ample evidence indicates that a high-protein/low-carbohydrate diet increases glucose energy expenditure and is beneficial in patients with type-2 diabetes mellitus (T2DM). The present study was designed to investigate the effects of L-tryptophan T2DM. Blood measured by dehydrogenase assay serum insulin ELISA both normal hereditary T2DM rats after oral administration or without L-D-tryptophan tryptamine. effect tryptophan on absorption examined small intestine using everted-sac method....
Fish oil-derived long-chain monounsaturated fatty acids (LCMUFAs) with a carbon chain length longer than 18 units ameliorate cardiovascular risk in mice. In this study, we investigated whether LCMUFAs could improve endothelial functions mice and humans. double-blind, randomized, placebo-controlled, parallel-group, multi-center healthy subjects were randomly assigned to either an LCMUFA oil (saury oil) or control (olive tuna oils) group. Sixty enrolled administrated each for 4 weeks. For the...
c-Cbl plays an important role in whole-body fuel homeostasis by regulating insulin action. In the present study, we examined of Cbl-b, another member Cbl family, action.C57BL/6 (Cbl-b(+/+)) or Cbl-b-deficient (Cbl-b(-/-)) mice were subjected to and glucose tolerance tests a hyperinsulinemic-euglycemic clamp test. Infiltration macrophages into white adipose tissue (WAT) was assessed immunohistochemistry flow cytometry. We macrophage activation using co-cultures 3T3-L1 adipocytes peritoneal...
The mechanism by which replacement of some dietary carbohydrates with protein during weight loss favors lipid metabolism remains obscure. In this study, we investigated the effect an energy-restricted, high-protein/low-carbohydrate diet on in obese rats. High-sucrose-induced rats were assigned randomly to one two energy-restricted interventions: a carbohydrate-based control (CD) or high-protein (HPD). Lean same age as normal control. There was significantly greater improvement fatty liver...
Insulin and nutrients activate hepatic p70 S6 kinase (S6K1) to regulate protein synthesis. Paradoxically, activation of S6K1 also leads the development insulin resistance. In this study, we investigated effect TRB3, which acts as an endogenous inhibitor Akt, on activity in vitro vivo. cultured cells, overexpression TRB3 completely inhibited insulin-stimulated by mammalian target rapamycin, whereas knockdown increased both basal activity. C57BL/6 mice, adenoviral S6K1. contrast, did not...
In vascular smooth muscle cells, large-conductance Ca2+-activated K+ channels (KCa channels) play a pivotal role in determining membrane potential, and thereby the tone. Ginsenoside Re, phytochemical from ginseng, is reported to activate this channel, but its precise mechanism unsolved. Patch clamp studies showed that ginsenoside Re activates KCa arterial cell line A10 dose-dependent manner. The channel-opening effect of was inhibited by 1 µM L-NIO, an inhibitor eNOS, not 3 SMTC, nNOS,...
Background. Vibrio parahaemolyticus causes acute gastroenteritis and inflammations in humans. A variety of pathogenic bacteria can stimulate mitogen-activated protein kinases (MAPKs) host cells. Phosphorylation MAPKs leads to production interleukin (IL)— 8 subsequently inflammations. Thus, MAPK cascades were strong candidates for the main signaling pathway V. parahaemolyticus-induced inflammation Methods. To determine whether on infection induces inflammation, we analyzed secretion level...
In inflammatory and oxidative liver injury, virus proteins reactive oxygen species are involved in the regulation of proinflammatory cytokine production by macrophages. This study investigated effects estradiol (E2) progesterone on unstimulated stress-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, macrophage protein (MIP)-2, chemotactic (MCP)-1 peritoneal macrophages isolated from male female mice. E2 inhibited TNF-alpha, IL-1beta, MIP-2, MCP-1 males females, which was...
Abstract Background The hfq gene is conserved in a wide variety of bacteria and Hfq involved many cellular functions such as stress responses the regulation expression. It has also been reported that bacterial pathogenicity. However, it not clear whether regulates virulence Vibrio parahaemolyticus . To evaluate this, we investigated effect on expression virulence-associated genes including thermostable direct hemolysin (TDH), which considered to be an important factor V. , using deletion...
Hyperphosphatemia causes endothelial dysfunction as well vascular calcification. Management of serum phosphate level by dietary restriction or binders is considered to be beneficial prevent chronic kidney disease patients from cardiovascular disease, but it has been unclear whether keeping lower can ameliorate dysfunction. In this study we investigated low-phosphate diet in adenine-induced rats, one useful animal model disease. Administration 0.75% adenine-containing for 21 days induced...
High serum phosphorus (P) impairs endothelial function by increasing oxidative stress and decreasing nitric oxide production. Serum P levels fluctuate due to circadian rhythms or dietary intake in healthy people dialysis end-stage chronic kidney disease patients. Here we examined whether fluctuating plasma caused changes may be involved dysfunction, resulting increased cardiovascular risk. Rats were fed a diet containing 0.6% for 16 days (control group), alternating between 0.02% 1.2% (LH...
The primary determinant of circulating 1α,25-dihydroxyvitamin D (1,25[OH](2)D) levels is the activity 25-hydroxyvitamin D-1α-hydroxylase (cytochrome P450 27B1 [CYP27B1]) in kidney. Hyperthyroid patients have been reported to low plasma 1,25(OH)(2)D. However, detailed mechanism thyroid hormone action on vitamin metabolism still poorly understood. present study determined whether renal CYP27B1 gene expression was negatively regulated by hormones. T(3)-induced hyperthyroid mice showed marked...
To assess the effect of taurine supplementation on respiratory gas exchange, which might reflect improved metabolism glucose and/or lipid in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats.Male OLETF rats (16 weeks age) were randomly divided into two groups: unsupplemented group and taurine-supplemented (3% drinking water) group. After 9 treatment, indirect calorimetry insulin tolerance tests conducted. The amounts visceral fat pads, tissue glycogen, blood concentrations...