A5103242317- Spinal Cord Injury Research
- Nitric Oxide and Endothelin Effects
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Orthopaedic implants and arthroplasty
- Neuroscience of respiration and sleep
- Eicosanoids and Hypertension Pharmacology
- Hip and Femur Fractures
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Dermatological and Skeletal Disorders
- Musculoskeletal pain and rehabilitation
- Nuclear Structure and Function
- Biotin and Related Studies
- Cancer Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Spine and Intervertebral Disc Pathology
- Sleep and Wakefulness Research
- Management of metastatic bone disease
- Skin and Cellular Biology Research
- Skin Diseases and Diabetes
- Vitamin D Research Studies
- Hip disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Peripheral Artery Disease Management
Shiga Medical Center
2021
Uji Hospital
1991-2002
Tokushima University
1967-1996
Abstract The effect of a T-C transition polymorphism at the translation initiation codon human vitamin D receptor (VDR) gene on biological function encoded protein was investigated. Of 239 Japanese women volunteers subjected to genotype analysis for this polymorphism, 32 (13%) were MM (the M allele is ATG putative start site), 75 (31%) mm m ACG and 132 (55%) Mm. bone mineral density (BMD) in lumbar spine (L2–L4) determined 110 healthy premenopausal from shown be 12.0% greater (p <...
In view of a cytoprotective effect elastase inhibitor on chemokine-mediated tissue injury, we examined the neuroprotective ONO-5046, specific neutrophil elastase, in rats with spinal cord injury. Standardized compression markedly increased cytokine-induced chemo-attractant (CINC)-1 mRNA and protein. Their increases correlated neurologic severity injured rats. Immunohistochemically, CINC-1 protein was detected sequentially vascular endothelial cells at 4 h, perivascular neutrophils 8...
A standardized compression injury of rat spinal cord brought about a time-dependent biphasic production thromboxane A2 (detected as B2) and prostaglandin I2 6-ketoprostaglandin F1alpha). Thromboxane B2 was predominant during the first 1 h, whereas F1alpha level exceeded that at 8 h postinjury. As examined by inhibitor experiments northern blotting, cyclooxygenase-1 responsible for phase, cyclooxygenase-2 involved in second phase. On levels interleukin-1alpha -1beta detected mRNA protein...
For the study on sleep, especially paradoxical cats have been usually utilized.However, according to purpose of study, small animals as rats, guinea pigs are also useful.This was designed investigate standard indices concerning normal sleep cycle albino rats during 24 hours.Nine adult male weighing between 280 and 350 g were used.All experiments began 1 3 p.m. lasted until next day from October March.Two pairs screw electrodes implanted in skull overlying frontal occipital cortices under...
In an attempt to elucidate a possible role for eicosanoids in the pathogenesis of spinal cord injury (SCI), we measured concentration leukotriene (LT) C4, thromboxane B2, and 6-keto-prostaglandin F1 alpha cerebrospinal fluid both canine experimental model 11 patients with SCIs.The eicosanoid was by radioimmunoassay. Neurological severity assessed according grading system Frankel et al.. Control samples were obtained from 20 without SCIs.In model, significant increase all levels found on Days...
OBJECTIVE: In an attempt to elucidate a possible role for eicosanoids in the pathogenesis of spinal cord injury (SCI), we measured concentration leukotriene (LT) C4, thromboxane B2, and 6-keto-prostaglandin F1α cerebrospinal fluid both canine experimental model 11 patients with SCIs. METHODS: The eicosanoid was by radioimmunoassay. Neurological severity assessed according grading system Frankel et al. (11). Control samples were obtained from 20 without RESULTS: model, significant increase...
We report a case of 74-year-old woman who underwent revision surgery acrylic femoral head prosthesis (Katayama-Hirakawa type) 32 years after the replacement. At 42-years old, she suffered left neck fracture, and as result, replacement using prosthesis, which enjoyed painless daily life for about 30 years. In March 1995, coxalgia was followed by gradual increasing pain. She therefore in August 1996. found 3 damaged parts removed prosthesis. These include distortion proximo-medial stem, crack...
Case: A 51-year-old woman presented with a 2-month history of pain in the right thigh. Radiography and computed tomography pelvis showed cortical hyperostosis ilium. She was diagnosed meralgia paresthetica (MP) caused by melorheostosis involving After 6 weeks conservative management, an operation performed for persisting pain. At 1-year follow-up, no findings recurrence were observed clinically radiographically. Conclusion: MP, proximal irritation lateral femoral cutaneous nerve, can occur...
We will present three patients whose gaits were disturbed by destroyed joints in their lower extremities.There was one case of rheumatoid arthritis the mutilans type, radiographic findings similar to those Charcot's joint, The othere two had Joints with destruction ankle joint caused diabetic mellitus and knee spondyloschisis other.We performed intravenous digital subtraction angiographies (IV-DSA) both extremities on all cases. angiografic showed an abnormally rapid venous filling a...
Recently percutaneous nucleotomy (PN) has been paid attention to as an excellent procedure for uncomplicated herniated lumbar discs.We have performed PN on 16 patients, which were followed up a short period. Twelve out of patients showed good results and others unsuccessful. Two unsuccessful group went further surgical procedures, in we observed fibrous membrane around nerve root one patient mass beneath S1 the other.We suppose factor age influences upon efficasy PN, because younger less...
We have applied 15 Harris-Galante cementless porous-coated prostheses in 14 patients, comprising cases of intracapsular fracture, osteoarthritis, rheumatoid-arthritis, and femomal head necrosis. The patients were separated radiographically two groups based on the preoperative Singh index.Postoperatively JOA scores compared between groups.Three male, 11 female. mean age at operation was 64.9 years (42-89 years). followup period 46.7 months (range: 27-74 months). average post Sigificant...
Metastatic bone tumors were treated by reimplantation of the resected after autoclaving, with filling defects caused tumor resection using fresh autogenous grafts.Case 1. A 67-year-old woman lung cancer had a lytic lesion in right lesser trochanter. At operation, proximal quarter femur was excised and autoclaved. long-stem prosthesis then inserted through autoclaved remainder femur. She able to walk cane for 14 months operation until her death from metastatic brain tumor.Case 2. 56-year-old...