A5100348126- RNA Interference and Gene Delivery
- Land Use and Ecosystem Services
- Plant Stress Responses and Tolerance
- CRISPR and Genetic Engineering
- Mesenchymal stem cell research
- Hepatitis B Virus Studies
- Blood groups and transfusion
- Plant Micronutrient Interactions and Effects
- Platelet Disorders and Treatments
- Adipose Tissue and Metabolism
- Sperm and Testicular Function
- Viral gastroenteritis research and epidemiology
- Cancer, Hypoxia, and Metabolism
- Gene Regulatory Network Analysis
- Viral Infections and Immunology Research
- Peroxisome Proliferator-Activated Receptors
- Aluminum toxicity and tolerance in plants and animals
- RNA modifications and cancer
- Plant nutrient uptake and metabolism
- Plant Water Relations and Carbon Dynamics
- Pluripotent Stem Cells Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis C virus research
Peking Union Medical College Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Sichuan University of Science and Engineering
2022-2024
Fudan University
2003-2024
Fujian Agriculture and Forestry University
2013-2024
First Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Sinopec (China)
2023-2024
Soochow University
2023-2024
Zhongnan Hospital of Wuhan University
2023-2024
Wuhan University
2023-2024
Polystyrene microplastics (PS-MPs) can threaten human health, especially male fertility. However, most existing studies have focused on the adulthood stage of reproduction toxicity caused by relatively short-term PS-MP exposure. This study aimed to investigate toxic effect PS-MPs testicular development and reproductive function upon prenatal postnatal Pregnant mice their offspring were exposed 0, 0.5 mg/L, 5 50 mg/L through daily drinking water from gestational day 1 (PND) 35 or PND70. We...
Abstract Background Triglyceride-glucose (TyG) index has been determined to play a role in the onset of metabolic syndrome (MetS). Whether TyG and with combination obesity indicators are associated clinical outcomes MetS population remains unknown. Method Participants were extracted from multiple cycles National Health Nutrition Examination Survey (NHANES) between 1999 2018 years. Three constructed including index, combining waist circumference (TyG-WC), waist-to-height ratio (TyG-WHtR). The...
Inadequate surgical hemostasis may lead to transfusion and/or other bleeding-related complications. This study examines the incidence and costs of complications blood product transfusions occurring as a consequence surgery in various inpatient cohorts.A retrospective analysis was conducted using Premier's Perspective™ hospital database. Patients who had an procedure within specialty interest (cardiac, vascular, non-cardiac thoracic, solid organ, general, reproductive knee/hip replacement, or...
Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability free arachidonate cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A(2)s (PLA(2)s), most notably cytosolic PLA(2)-alpha. 10 secreted PLA(2)s (sPLA(2)s) have also been identified, but their function generation poorly understood. We investigated role group X sPLA(2) (sPLA(2)-X), with highest vitro cellular...
Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals. In this study, we investigated the role of FGF21 metabolic activity sodium butyrate, a dietary histone deacetylase (HDAC) inhibitor. expression was examined serum liver after injection butyrate into obese C57BL/6J mice. The determined using antibody neutralization or knockout transcription HepG2 hepatocytes. Trichostatin A (TSA) used control as an HDAC Butyrate compared with bezafibrate...
Significance Breast cancer is one the most common cancers and causes of cancer-related death worldwide. Tumor recurrence following therapy attributed to a subset tumor-initiating cells (TICs) with stem cell (SC) properties. Similar normal adult SCs that drive tissue regeneration, TICs regenerate tumors after treatment thereby enable dissemination throughout body. Thus, better appreciation mechanisms induce maintain in neoplastic tissues critical for understanding regeneration improving...
Oxidative stress underlies a number of pathological conditions, including cancer, neurodegeneration, and aging. Antioxidant-rich foods help maintain cellular redox homeostasis mitigate oxidative stress, but the underlying mechanisms are not clear. For example, sulforaphane (SFN), an electrophilic compound that is enriched in cruciferous vegetables such as broccoli, potent inducer antioxidant responses. NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2), transcriptional factor controls...
Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear whose activation dependent on ligand. PPARγ by exogenous ligands, such as thiazolidinediones (TZDs), strategy in the treatment of type 2 diabetes mellitus for improvement insulin sensitivity. In addition to ligand, function also regulated posttranslational modifications, phosphorylation, sumoylation, and ubiquitination. Herein, we report that protein modified acetylation, which induces absence an external We observed...
Multiomic profiling of single cells by sequencing is a powerful technique for investigating cellular diversity. Existing droplet-based microfluidic methods produce many cell-free droplets, underutilizing bead barcodes and reagents. Combinatorial indexing on microplates more efficient barcoding but labor-intensive. Here we present Overloading And unpacKing (OAK), which uses system initial compartmentalization followed second aliquoting round to achieve combinatorial indexing. We demonstrate...
Genome replication in eukaryotic cells necessitates the stringent coupling of histone biosynthesis with onset DNA at G1/S phase transition. A fundamental question is mechanism that links restriction (R) point late G1 gene expression S phase. Here we demonstrate HiNF-P, a transcriptional regulator replication-dependent H4 genes, interacts directly p220(NPAT), substrate cyclin E/CDK2, to coactivate genes during HiNF-P and p220 are targeted to, colocalize at, subnuclear foci (Cajal bodies) cell...
Primordial germ cell (PGC) specification is the first crucial step in line development. However, owing to significant challenges regarding vivo system, such as complex cellular environment and potential problems with embryo manipulation, it desirable generate embryonic stem (ES) cells that are capable of overcoming these aforementioned limitations order provide a vitro model recapitulate developmental processes vivo.Here, we studied detailed process PGC from stella-GFP ES cells. We observed...
Insulin degrading enzyme (IDE) is a potential drug target in the treatment of type 2 diabetes (T2D). IDE controls circulating insulin through degradation-dependent clearance mechanism multiple tissues. However, there not sufficient information about regulation obesity. In this study, we test obesity-associated factors and pioglitazone diet-induced obese (DIO) C57BL/6 mice. The activity protein level were increased liver DIO Pioglitazone (10 mg/kg/day) administration for months significantly...
Abstract Background Very little is known about manganese (Mn)-toxicity-responsive genes in citrus plants. Seedlings of ‘Xuegan’ ( Citrus sinensis ) and ‘Sour pummelo’ grandis were irrigated for 17 weeks with nutrient solution containing 2 μM (control) or 600 (Mn-toxicity) MnSO 4 . The objectives this study to understand the mechanisms Mn-tolerance identify differentially expressed genes, which might be involved Mn-tolerance. Results Under Mn-toxicity, majority Mn seedlings was retained...
Current approved nucleoside analogue treatments for chronic hepatitis B virus (HBV) infection are effective at controlling viral titer but not curative and have minimal impact on the production of proteins such as surface antigen (HBsAg), HBV envelope protein believed to play a role in maintaining immune tolerant state required persistence. Novel agents needed effect cure, reduction antigenemia may potentiate activation long-lasting host control. ARB-1740 is clinical stage RNA interference...
Magnesium (Mg)-deficiency is one of the most prevalent physiological disorders causing a reduction in Citrus yield and quality. 'Xuegan' (Citrus sinensis) seedlings were irrigated for 16 weeks with nutrient solution containing 2 mM (Mg-sufficiency) or 0 (Mg-deficiency) Mg(NO3)2. Thereafter, we investigated Mg-deficient effects on gas exchange chlorophyll fluorescence upper lower leaves, Mg, reactive oxygen species (ROS) methylglyoxal (MG) metabolisms roots, leaves. The specific objectives to...