A5074513249- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gut microbiota and health
- Gastrointestinal motility and disorders
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- MicroRNA in disease regulation
- Cancer-related gene regulation
- RNA modifications and cancer
- Wound Healing and Treatments
Kyoto Prefectural University of Medicine
2016-2025
University Hospital Kyoto Prefectural University of Medicine
2024-2025
Affiliated Hospital of Qingdao University
2024
Takeda (France)
2024
Qingdao University
2024
Kyoto City Hospital
2024
RELX Group (Netherlands)
2024
Yamashina Institute for Ornithology
2023
Kyoto first Red Cross hospital
2023
National Institute of Diabetes and Digestive and Kidney Diseases
2021-2023
Although radical surgery is recommended for patients not meeting the curative criteria endoscopic submucosal dissection (ESD) of early gastric cancer (EGC) because potential risk lymph node metastasis (LNM), this recommendation may be overestimated and excessive. We aimed to establish a simple scoring system decision making after ESD.This multicenter retrospective study consisted two stages. First, risk-scoring LNM was developed using multivariate logistic regression analysis in 1,101 who...
Linked color imaging (LCI) is a new image-enhanced endoscopy technique using laser light source to enhance slight differences in mucosal color. The aim of this study was compare the usefulness LCI and conventional white (WLI) for diagnosing Helicobacter pylori (H. pylori).We retrospectively analyzed images from 60 patients examined with WLI between October 2013 May 2014. Thirty had H. infections, other thirty tested negative after eradication therapy. Four endoscopists evaluated 2 types...
Proton pump inhibitors (PPIs) are widely used to treat gastro-esophageal reflux and prevent gastric ulcers, have been considered as low risk. However, recent studies identified possible associations between PPI use gut microbiota, suggesting that PPIs increases the risk of enteric infections, including Clostridium difficile infection. To investigate microbiota in Japanese users, we conducted 16S metagenomics analysis fecal samples collected from users healthy adults. In total, 36 non-users...
Background: Linked color imaging (LCI) is a new image-enhanced endoscopy technique that allows users to recognize slight differences in mucosal color. Objective: To compare the performance of LCI with white light (WLI) detecting neoplastic lesions upper gastrointestinal tract. Design: A controlled, multicenter trial randomization using minimization. (University Hospital Medical Information Network Clinical Trials Registry: UMIN000023863) Setting: 16 university hospitals and 3 tertiary care...
Abstract Background Data on endoscopic resection (ER) for superficial duodenal epithelial tumors (SDETs) are insufficient owing to their rarity. There two main ER techniques SDETs: mucosal (EMR) and submucosal dissection (ESD). In addition, modified EMR techniques, such as underwater (UEMR) cold polypectomy, becoming popular. We conducted a large-scale retrospective multicenter study clarify the detailed outcomes of ER. Methods Patients with SDETs who underwent at 18 institutions from...
MicroRNAs (miRNAs) are small non-coding RNAs that function as endogenous silencers of target genes. Some tumor-suppressive miRNAs known to be epigenetically silenced by promoter DNA methylation in cancer. In the present study, we aimed identify miRNA genes hypermethylation hepatocellular carcinoma (HCC). We screened for with using a genome-wide microarray analysis HCC cells. It was found miR-335, which is harbored within an intron its protein-coding host gene, MEST, downregulated aberrant...
The aberrant expression or alteration of microRNAs (miRNAs/miRs) contributes to the development and progression cancer. In present study, functions miR-96-5p in hepatocellular carcinoma (HCC) were investigated. It was identified that significantly upregulated primary HCC tumors compared with their non-tumorous counterparts. A copy number gain frequently observed at chromosomal region 7q32.2 which MIR96 locus is located, suggesting gene amplification may be one mechanisms by increased HCC....
Background and Aim With the aging of society, comorbidities or nutritional status are assessed prior to endoscopic submucosal dissection ( ESD ) for early gastric cancer EGC ). However, it is uncertain which factors important predicting prognosis in patients after . Thus, we aimed evaluate clinical outcomes , with respect status. Methods We carried out a retrospective study involving 708 585 who were enrolled between April 2007 March 2012. They classified into two groups; an elderly (≥80...
Functional dyspepsia (FD) is associated with poor health-related quality of life. Recent evidence suggests that the main pathogenesis suspect gut mucosa-associated microbiota (MAM). However, little known about MAM in FD subjects. The aim this study was to clarify relationship between upper gastrointestinal symptoms and characteristics MAM.Five mucosa samples from (intraoral, mid-esophagus, gastric body, antrum, descending portion duodenum) were collected a brush under endoscopic examination...
Fibroblast activation protein (FAP)/seprase and dipeptidylpeptidase-IV (DPP-IV)/CD26 are serine integral membrane proteases. They involved in tissue remodelling, cancer invasion metastases, mechanisms that controversial. The aim was to identify cell types express FAP DPP-IV human bone soft tumours, determine whether there any correlations between the expression of malignant potential tumours.This study analysed situ 25 13 benign tumours. Reverse transcriptase-polymerase chain reaction...
Cold snare polypectomy (CSP) is commonly used for treating colorectal polyps <10 mm in diameter. We evaluated the analysis and safety of CSP larger polyps.We retrospectively analyzed 1006 resected with CSP. Indication was 2-14 that were diagnosed as benign neoplastic polyp by magnifying endoscopy. Various clinicopathological characteristics analyzed. Multivariate analyses to determine independent risk factors failure complete resection. With respect size, we compared therapeutic outcomes...
The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of esophagus. However, esophagectomy with extended lymph node dissection is highly invasive. Recent reports have shown that endoscopic (ESD) followed by chemoradiotherapy (CRT) promising results and might become a new therapeutic approach. This retrospective study aimed to elucidate efficacy safety this treatment. Patients clinical...
Mucosal healing and control of intestinal mucosal inflammation are important treatment goals for maintaining clinical remission in ulcerative colitis [UC] patients. Here, we investigated the efficacy linked colour imaging [LCI], a novel endoscopic enhancement system, diagnosing UC patients.All examinations were carried out with LASEREO system [FUJIFILM Co., Tokyo, Japan]. Fifty-two patients enrolled, 193 areas assessed by LCI examined. patterns classified as; A, no redness; B, redness...