A5101772319- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Asthma and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Lung Cancer Diagnosis and Treatment
- Alzheimer's disease research and treatments
- TGF-β signaling in diseases
- Glaucoma and retinal disorders
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Retinal Imaging and Analysis
- Bone health and treatments
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Kruppel-like factors research
- Colorectal Cancer Treatments and Studies
- Sirtuins and Resveratrol in Medicine
- Glutathione Transferases and Polymorphisms
Shanghai Tenth People's Hospital
2009-2025
Tongji University
2016-2025
Tohoku University
2024
Zhongyuan University of Technology
2024
Zhejiang University
2015-2023
Shaoxing University
2023
Sir Run Run Shaw Hospital
2015-2022
Shanghai Pulmonary Hospital
2013-2022
Blood Center of Zhejiang Province
2019-2022
Guilin Medical University
2013-2021
As a subclass of noncoding RNAs, circular RNAs (circRNAs) have been demonstrated to play critical role in regulating gene expression eukaryotes. Recent studies revealed the pivotal functions circRNAs cancer progression. However, little is known about circTADA2A, also named hsa_circ_0043278, osteosarcoma (OS).CircTADA2A was selected from previously reported circRNA microarray comparing OS cell lines and normal bone cells. QRT-PCR used detect circTADA2A tissue lines. Luciferase reporter, RNA...
// Di Zheng 1, * , Min Hu 2, Yu Bai 2 Xuehua Zhu Xuesong Lu 3 Chunyan Wu 4 Jiying Wang 1 Li Liu Jian Ni Zhenfan Yang and Jianfang Xu Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School, Shanghai, China IMED Asia, AstraZeneca, Research Development Information, Pathology, These authors contributed equally to this work Correspondence to: Xu, email: xujianfang63@aliyun.com Yang, Pamela.Yang@astrazeneca.com Keywords: EGFR, NSCLC, osimertinib, drug resistance,...
Accumulating evidence suggests that dysregulated snoRNA may play a role in the development of malignancy. In present study, we investigated SNORD78 tumorigenesis non-small cell lung cancer (NSCLC).We determined expression level NSCLC tissues with quantitative real-time PCR and then studied its clinical significance. We explored biological significance gain-and-loss-of-function analyses both vitro vivo.A great upregulation was observed compared to their adjacent normal tissues. Meanwhile,...
Abstract One of the earliest signs age‐related macular degeneration (AMD) is formation drusen which are extracellular deposits beneath retinal pigmented epithelium (RPE). To investigate relationship between and AMD, we focused on amyloid β (Aβ), a major component also senile plaques in brain Alzheimer's patients. We previously reported that Aβ was accumulated drusen‐like structure senescent neprilysin gene‐disrupted mice. The purpose this study to influence factor B, main activator...
Osteoarthritis (OA) is a common, age-related, and painful disease characterized by cartilage destruction, osteophyte formation, synovial hyperplasia. This study revealed that circPDE4D, circular RNA derived from human linear PDE4D, plays critical role in maintaining the extracellular cellular matrix (ECM) during OA progression. circPDE4D was significantly downregulated tissues stimulation with inflammatory cytokines. The knockdown of predominantly contributed to Aggrecan loss upregulation...
Abstract The results of recent studies have implicated local inflammation and complement activation as the processes involved in pathogenesis age-related macular degeneration (AMD). We demonstrated that amyloid β (Aβ), which is deposited drusen, causes an imbalance angiogenesis-related factors retinal pigment epithelial cells. also shown neprilysin gene-disrupted mice accumulate Aβ, develop several features AMD. purpose this study was to investigate mechanisms development AMD are triggered...
Aim. To investigate bone metabolic characteristics in Chinese adults with nonalcoholic fatty liver disease (NAFLD). Methods. A total of 224 patients (99 males and 125 postmenopausal females) were recruited divided into 4 groups: without NAFLD, females NAFLD. Bone mineral density (BMD) was evaluated according to body mass index (BMI), waist circumference (WC), serum biomarkers. β cell function by HOMA2%B, HOMA2%S, HOMA2IR. Results. Males the NAFLD group had lower BMD right hip femoral neck...
Modic changes are the MRI signal of degenerative lumbar vertebral endplate and which lead to or accelerate intervertebral disc degeneration. NLRP3, caspase-1, interleukin-1β (IL-1β) play a pivotal role in pathogenesis many inflammatory diseases, such as osteoarthritis. However, roles IL-1β its activators caspase-1 NLRP3 unclear endplate.We asked: (1) What histologic features chondrogenic markers' gene expressions between cartilaginous endplates patients with trauma (control)? (2) How does...
ABSTRACT Osteoporosis develops because of impaired bone formation and/or excessive resorption. Although the pharmacological treatment osteoporosis has been extensively developed, alternative treatments are still needed. Here, we showed that oridonin (ORI), a diterpenoid isolated from Rabdosia rubescens, can suppress osteoclastogenesis and enhance osteogenesis. ORI inhibited receptor activator nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclast resorption through inhibition p65...
Long noncoding RNAs (lncRNA) play critical roles in cancer development. In this study, we aimed to explore the function and possible molecular mechanism of HMMR-AS1 involved lung adenocarcinoma (LUAD).Firstly, analyzed expression LUAD tissues with sequencing data from The Cancer Genome Atlas (TCGA). Next, evaluated effects on cell proliferation apoptosis, its regulation miR-138 by acting as a ceRNA. animal model was used support vitro experimental findings.HMMR-AS1 significantly upregulated...
Lung cancer is one of the most common and lethal malignant tumors cases increased rapidly. Elevated chemoresistance during chemotherapy resistance remains a challenge. Hypoxia components that lead to chemoresistance. PVT1 participates in various tumor drug associated with hypoxia conditions. The present study aimed analyze regulatory relationship mechanism hypoxia-induced process lung cancer. expression adjacent tissues, cell lines were analyzed using TCGA database qPCR. between was...
Mutations and altered expression of deubiquitinating enzymes (DUBs) profoundly influence tumor progression.Ubiquitin-specific protease 1 (USP1) is a well-characterized human DUB reportedly overexpressed in associated with maintaining the mesenchymal stem cell status osteosarcoma (OS); however, potential mechanisms USP1 OS remain poorly understood.In this study, we identified that directly interacts Transcriptional Co-Activator With PDZ-Binding Motif (TAZ) lines, mechanistic analysis...
High incidence of osteoporotic fractures emphasizes the necessity developing effective measures to promote osteogenesis. In our study, we investigated a possible role MAPK‐ERK signaling in TGF‐β‐mediated osteoblastic differentiation. Our results indicated that TGF‐β activated pathway and inhibited osteogenesis mesenchymal pluripotent cell line, C3H10T1/2, preosteoblastic MC3T3 cells. And downregulation using pharmacological inhibitor U0126 RNA interference rescued osteoblast differentiation...
Abstract This study aimed to explore the underlying mechanism of miR‐513b and HMGB3 in regulating non‐small‐cell lung cancer (NSCLC). NSCLC tumor, adjacent tissues, cell lines were extracted, expression determined by quantitative real‐time polymerase chain reaction (RT‐qPCR) western blot analysis. Then, was overexpressed cell, proliferation, migration, invasion, apoptosis cells 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT), wound healing, transwell, flow cytometry,...
Abstract Osteoporosis-related fractures, such as femoral neck and vertebral are common in aged people, resulting increased disability rate health-care costs. Thus, it is of great importance to clarify the mechanism osteoclast-related osteoporosis find effective ways avoid its complication. In this study, gene expression profile analysis real-time polymerase chain reaction revealed that DUSP6 was suppressed human mice cases. vitro experiments confirmed overexpression prevented...
Leukemia stem cells (LSCs) reside in bone marrow niche and receive important signals from the microenvironment that support self‐renewal, maintain quiescence endow LSC with ability of chemotherapy resistance. Rac1 belongs to small GTP‐binding protein superfamily is implicated interactions hematopoietic progenitors niche. Our previous studies have shown over‐expressed leukemia patients activation GTPase closely associated efficient migration cells. However, potential functions for LSCs...
To investigate the clinical effects of whole brain radiotherapy concomitant with targeted therapy for metastasis in non-small cell lung cancer (NSCLC) patients chemotherapy failure.Of 157 NSCLC failure followed by admitted our hospital from January 2009 to August 2012, combination group (65 cases) were treated EGFR-TKI combined while (92 given only. Short-term evaluated based on increased MRI 1 month after radiotherapy. Intracranial hypertension responses, hematological toxicity reactions...