Abstract Direct conversion of CO 2 into carbon‐neutral fuels or industrial chemicals holds a great promise for renewable energy storage and mitigation greenhouse gas emission. However, experimentally finding an electrocatalyst specific final products with high efficiency selectivity poses serious challenges due to multiple electron transfer, complicated intermediates, numerous reaction pathways in electrocatalytic reduction. Here, intrinsic descriptor that correlates the catalytic activity...

High- T c superconductivity with possible ≈ 80 K has been reported in the single crystal of La 3 Ni 2 O 7 under high pressure. Based on electronic structure given by density functional theory calculations, we propose an effective bi-layer model Hamiltonian including both d z and x – y orbital electrons nickel cations. The main feature is that form inter-layer σ -bonding anti-bonding bands via apical oxygen anions between two layers, while hybridize within each NiO plane. chemical potential...

Clear delineation of tumor margins is essential for accurate resection and decreased recurrence rate in the clinic. Fluorescence imaging emerging as a promising alternative to traditional visual inspection by surgeons intraoperative imaging. However, probes lack accuracy diagnosis, making it difficult depict boundaries accurately. Herein, we proposed an offensive defensive integration (ODI) strategy based on "attack systems (invasive peptidase) defense (reductive microenvironment)"...

Cytosolic delivery is the major challenge that limits clinical translation of siRNA-based therapeutics. Although thousands polymers have been developed for siRNA delivery, efficiency-toxicity correlation unsatisfactory. Here, we report a facile strategy to fabricate core-shell-structured nanoparticles with robust efficiency. The nanoparticle prepared by entropy-driven complexation green tea catechin yield negatively charged core, followed coating low-molecular-weight form shell. This...

Ca and Mn co-doped BiFeO3 (BFO) thin films were fabricated on (111) Pt/Ti/SiO2/Si substrates via a simple solution approach. Enhanced ferroelectric properties obtained in these BFO films, e.g., large remnant polarization value (Pr ∼ 89 μC/cm2) to saturated ratio (Pr/Ps 0.84) for Bi0.90Ca0.10Fe0.90Mn0.10O3 film. X-ray diffraction Raman spectra of showed that B-site doping causes substantial structural transition toward orthorhombic phase A-site facilitates an evolution tetragonal with higher...

There is a continuing quest to rationally fabricate polymeric biomaterials with both high transfection efficiency and minimal toxicity for the emerging opportunities in small interfering RNA (siRNA...

Advancement of technologies relies on discovery new materials with emerging physical properties that are determined by their crystal structures.2][3][4][5][6] In R-P phases, intergrowth is well-known in the short range; 7-9 however, no existing compounds have been reported to different n mixed bulk single crystals.Here we design a hybrid nickelate La2NiO4•La3Ni2O7 alternatively stacking bilayers, which active structural motif newly high-Tc superconductor La3Ni2O7 and layers antiferromagnetic...

Abstract The first catalytic asymmetric [3+2] cycloaddition of 2‐indolylmethanols with 3‐vinylindoles has been established, which makes use C‐3 unsubstituted 2‐indolylmethanol as a C 3 building block in the presence chiral phosphoric acid. By using this strategy, biologically important cyclopenta[ b ]indole frameworks were efficiently constructed regiospecificity high yields (up to 99%), excellent diastereo‐ and enantioselectivities >95:5 dr , 96:4 er ). This reaction not only represents...

The first catalytic asymmetric α-arylation of pyrazol-5-ones has been established by using 2-indolylmethanols as direct electrophilic arylation reagents under the cooperative catalysis Pd(0) and a chiral phosphoric acid, which afforded products in generally high yields good enantioselectivities (up to 99% yield, >99% ee).

Abstract A highly enantioselective [3+2] cyclization of 3‐vinylindoles with isatin‐derived 3‐indolylmethanols has been established in the presence chiral phosphoric acid, which constructed enantioenriched cyclopenta[ b ]indole scaffold linking a 3‐vinylindole moiety generally good yields, considerable diastereoselectivities and high enantioselectivities (up to 93%, >95:5 dr , >99.5:0.5 er ). More importantly, this reaction utilized N‐protected as competent reactants, confronted...

An asymmetric allylic C-H alkylation of allyl ethers has been established by chiral phosphoramidite-palladium catalysis, affording a wide variety functionalized 2-acylimidazoles in moderate to high yields and with levels enantioselectivity. Moreover, this protocol could be applied concise synthesis tachykinin receptor antagonist.

Previous studies have demonstrated that polypeptides extracted from fish protein possess potential anti-inflammatory effects, but few reported the underlying mechanism of sturgeon peptides. Hence, goal this study was to explore peptide sequences with activity derived muscle in lipopolysaccharide (LPS)-induced RAW264.7 inflammatory model. Fourteen novel peptides were identified major proteins by mass spectrometry, and three synthetic – KIWHHTF, VHYAGTVDY, HLDDALRGQE - decreased release...

Previous studies have suggested that polypeptides extracted from milk, soybean, fish, eggs, and meat possess potential anti-inflammatory effects. To date, few reported the function of sturgeon peptides their underlying mechanisms are unknown. The current study was therefore to determine with lipopolysaccharide (LPS)-induced RAW264.7 inflammatory model. Pepsin hydrolysate (PeH) purified by ultrafiltration Sephadex G-15 gel filtration chromatography. PeH significantly reduced mediator (NO)...

Sturgeon hydrolysates (SH) dramatically decreased inflammatory cytokines, preserved intestinal structure, and increased beneficial bacteria by inhibiting NF-κB MAPK activation reshaping the gut microbiota.

Hydrogen sulfide (H2S), emerging as an important gaseous signal, has attracted more and attention for its key role in chronic fatty liver diseases. However, lacking tools H2S-specific situ detection, the changes of endogenous hepatic H2S levels pathological progression diseases are still unclear. To this end, we adopted a strategy combining molecular probe design nanofunctionalization to develop highly selective near-infrared (NIR) fluorescent probe, which allows vivo real-time monitoring...

Abstract The development of inorganic hole‐transporting materials (HTMs) is one the most reliable ways to improve stability perovskite solar cells (PSCs). However, un‐optimal buried interfacial contacts and defects located at HTMs/perovskite interface restricted device's performance. Herein, a phase‐pure CuScO 2 has been synthesized further employed as mesoporous HTM in inverted PSCs. Surprisingly, facile pretreatment hole‐transport layer by formamidine salt compensates I − vacancy film,...

High-Tc superconductivity with possible $T_{c}\approx 80K$ has been reported in the single crystal of $\text{La}_{3}\text{Ni}_{2}\text{O}_{7}$ under high pressure. Based on electronic structure given from density functional theory calculations, we propose an effective bi-layer model Hamiltonian including both $3d_{z^{2}}$ and $3d_{x^{2}-y^{2}}$ orbital electrons nickel cations. The main feature is that form inter-layer $\sigma$-bonding anti-bonding bands via apical oxygen anions between two...

Abstract Amyloid‐β (Aβ) and Tau proteins are the main components of Aβ plaques neurofibrillary tangles in Alzheimer's disease (AD), their abnormal aggregation is closely related to pathogenesis AD. The production reactive oxygen species (ROS) form a vicious circle, which leads aggravation However, inhibiting or scavenging ROS not able effectively reverse progression Herein, we prepared H 2 O responsive multifunctional nanocomposite UCNPs@mSiO ‐MB@AuNPs (abbreviated as USMA) inhibit Tau. In...

Abstract Glioblastoma, IDH-Wild type (GBM, CNS WHO Grade 4) is a highly heterogeneous and aggressive primary malignant brain tumor with high morbidity, mortality, poor patient prognosis. The global burden of GBM increasing notably due to limited treatment options, drug delivery problems, the lack characteristic molecular targets. OTU deubiquitinase 4 (OTUD4) potential predictive factor for several cancers such as breast cancer, liver lung cancer. However, its function in remains unknown. In...

We merge marital history data for respondents in the National Survey of Families and Households with census describing sex composition their local marriage markets occupations to examine impact availability spousal alternatives on dissolution. Proportional hazards regression models that adjust left truncation reveal risk divorce is highest geographically defined where either husbands or wives encounter numerous current partner. Couples are also more likely when wife works an occupation...

In the presence of visible-light photoredox and chiral phosphate catalysts, a novel asymmetric Friedel–Crafts reaction indoles readily accessible α-amino acid derived redox-active esters is established to afford enantioenriched 1-indolyl-1-alkylamine derivatives in moderate high yields with levels enantioselectivities. This method not only shows mild efficient alternative for situ generation N-acyl imines but also indicates feasibility multicatalyst system catalysis.