Ge Chen

ORCID: 0009-0004-0294-4635
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About
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Research Areas
  • TiO2 Photocatalysis and Solar Cells
  • Renal Transplantation Outcomes and Treatments
  • Pigment Synthesis and Properties
  • Advanced Photocatalysis Techniques
  • Complement system in diseases
  • Reproductive System and Pregnancy
  • T-cell and B-cell Immunology
  • Pancreatic and Hepatic Oncology Research
  • NF-κB Signaling Pathways
  • Mesoporous Materials and Catalysis
  • Cassava research and cyanide
  • Blood groups and transfusion
  • Transplantation: Methods and Outcomes
  • Meningioma and schwannoma management
  • RNA modifications and cancer
  • Immune Cell Function and Interaction
  • Biochemical and biochemical processes
  • Ovarian function and disorders
  • Adipokines, Inflammation, and Metabolic Diseases
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Nanomaterials for catalytic reactions
  • RNA Interference and Gene Delivery
  • Organ Transplantation Techniques and Outcomes
  • Ophthalmology and Visual Impairment Studies
  • Advanced Neuroimaging Techniques and Applications

Ministry of Agriculture and Rural Affairs
2024-2025

Institute of Vegetables and Flowers
2025

Capital Medical University
2015-2024

Guangxi Academy of Agricultural Science
2023-2024

Nanjing Normal University
2022-2024

Jiangsu University
2007-2023

Jiangxi Maternal and Child Health Hospital
2020-2023

Anyang Academy of Agricultural Sciences
2022

Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2021

Tongji Hospital
2021

Human leukocyte antigen (HLA) antibodies, especially those that fix complement, are associated with antibody-mediated rejection and graft failure. The C1q assay on single beads detects a subset of HLA antibodies can complement precede C4d deposition. aim this study was to determine whether C1q-fixing distinguish de novo donor-specific (DSA) clinically relevant harmful.We retrospectively studied 31 274 kidney transplant recipients who had pretransplant concurrent biopsy serum specimens, 13...

10.1097/tp.0b013e318203fd26 article EN Transplantation 2010-11-25

Sutherland SM, Chen G, Sequeira FA, Lou CD, Alexander SR, Tyan DB. Complement‐fixing donor‐specific antibodies identified by a novel C1q assay are associated with allograft loss. Pediatr Transplantation 2012: 16: 12–17. © 2011 John Wiley & Sons A/S. Abstract: Long‐term outcomes following renal transplantation remain disappointing. Recently, interest has focused on the antibody‐mediated component of injury and deleterious effects DSA. We applied solid‐phase in parallel standard IgG SAB to...

10.1111/j.1399-3046.2011.01599.x article EN Pediatric Transplantation 2011-11-17

OsNramp5 is a key gene involved in the control of uptake Cd, Mn, and other metal ions by rice root cells. The functional deficiency this can significantly reduce accumulation Cd grains, but effects its mutation on agronomic traits such as yield quality have not been investigated comprehensively yet. In present study, three Huanghuazhan-based mutants [LCH1 (Low Cadmium Huanghuazhan 1), LCH2 2), LCH3 3)] were obtained using clustered regularly interspaced short palindromic...

10.3389/fpls.2019.01081 article EN cc-by Frontiers in Plant Science 2019-09-11

Abstract Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 in pregnancy remains be determined, evidence indicates that risk factors for severe COVID-19 similar general population. Here we systemically analyzed clinical characteristics pregnant and non-pregnant female patients who were hospitalized during same period found developed marked lymphopenia higher inflammation evident by C-reactive protein IL-6. To elucidate pathways might...

10.1038/s41392-021-00703-3 article EN cc-by Signal Transduction and Targeted Therapy 2021-07-29

Abstract Rheumatoid arthritis (RA) is a chronic and inflammatory autoimmune disease. Macrophage pyroptosis, proinflammatory form of cell death, critically important in RA; however, the detailed mechanism underlying pyroptosis induction not yet well understood. Here, we report that DNA polymerase β (Pol β), key enzyme base excision repair, plays pivotal role RA pathogenesis. Our data shows Pol expression significantly decreased peripheral blood mononuclear cells (PBMCs) from active patients...

10.1038/s41419-022-05047-6 article EN cc-by Cell Death and Disease 2022-07-06

Objective: The purpose was to explore whether video image can have a positive association with online word of mouth and intangible cultural heritage image. Theoretical Framework: We use SOR theory investigate the impact on Method: used questionnaire survey collected 242 from those who are individuals experience in seeing TikTok’s about heritage. Results Discussion: results enable us reveal role related activities, which helps managers utilize enhance promote Research Implications:...

10.26668/businessreview/2025.v10i3.5210 article EN International Journal of Professional Business Review 2025-03-06

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers with more than 94% mortality rate mainly due to widespread metastases. To find out somatically mutated genes related metastasis PDAC, we analyzed matched tumor and normal tissue samples from a patient diagnosed liver metastatic PDAC using intensive exome capture-sequencing analysis (> 170× coverage). Searching for somatic mutations that drive clonal expansion metastasis, identified 12 higher allele frequencies (AFs)...

10.4161/cbt.20839 article EN Cancer Biology & Therapy 2012-08-01

Interleukin-8 (IL-8) is an 8 kD chemokine and angiogenic factor produced by alveolar macrophages, endothelial cells, monocytes, fibroblasts. T lymphocytes, epithelial cells in response to a variety of stimuli, including LPS, TNF-α, IL-1, IL-7, hypoxia. Pulmonary tumors produce growth factors cytokines that may act both autocrine paracrine fashion. A549, well-characterized human lung adenocarcinoma line, was cloned for different levels IL-8 production limiting dilution. Clone 3B4 361 ± 73...

10.1089/jir.1996.16.53 article EN Journal of Interferon & Cytokine Research 1996-01-01

The alternatively spliced EIIIB, EIIIA. and V segments of fibronectin (FN) show widespread codistribution in the mouse embryo, suggesting that EIIIB+, EIIIA+, V+ isoforms serve to facilitate morphogenesis organogenesis (Peters, JH, Hynes, RO, 1996, this issue). To gain further clues functions these segments, we have used segment-specific anti-FN antibodies perform immunofluorescence microscopy on tissue sections obtained from mice aged 9 15 weeks. Staining for each three relative total FN...

10.3109/15419069609010767 article EN Cell adhesion and communications/Cell adhesion and communication/Cell adhesion & communication 1996-01-01

Hypoxia-inducible factor-1α (HIF-1α) is a major effector in cell survival response to hypoxia, while the roles of HIF-1α radiation-induced autophagy are still unclear breast cancer cells. Human carcinoma MCF-7 cells were stably transfected with pSUPER-shRNA against human or scrambled sequence no homology mammalian genes, named as pSUPER-HIF-1α and pSUPER-SC, respectively. Cell Counting Kit-8 (CCK-8) assay colony formation used detect viability, Western blot was protein expression,...

10.1007/s13277-015-3425-z article EN Tumor Biology 2015-04-14

In the present study, we aimed to investigate relationship between autophagy and apoptosis in selenite‑treated colorectal cancer (CRC) cells. The effects of selenite on HCT116 SW480 cell were investigated with an Annexin V/propidium iodide (PI) double staining kit by flow cytometry. punctate LC3 protein following treatment was observed a laser scanning confocal microscope transmission electron microscopy. Using western blot assays, detected apoptotic autophagic markers both CRC cells mouse...

10.3892/or.2015.4484 article EN cc-by-nc-nd Oncology Reports 2015-12-10

Chondroitin sulfate (CS) is a special bioactive substance with lipid metabolism regulation functions; its molecular mechanisms, however, need further study. This study aimed to the role of gut microbiota and liver metabolome in anti-obesity effects CS. The results demonstrated that CS significantly reduced body weight gain alleviated insulin resistance dyslipidemia induced by high-fat diet treatment. Moreover, interestingly increased content Firmicutes intestinal microbiota. Further studies...

10.1021/acs.jafc.3c02642 article EN Journal of Agricultural and Food Chemistry 2023-06-09

A series of Cu−Zn−M (M = Al, Ti, Zr) catalysts were prepared by coprecipitation method and characterized X-ray diffraction, photoelectron spectroscopy, N2 adsorption. The catalytic activity the catalyst in maleic anhydride hydrogenation using ethanol as a solvent was studied at 220−280 °C 1 MPa. presence MxOy favored deep to tetrahydrofuran. TiO2 support showed highest selectivity tetrahydrofuran followed sequence Cu−Zn−Ti > Cu−Zn−Zr ≈ Cu−Zn−Al.

10.1021/ie9013875 article EN Industrial & Engineering Chemistry Research 2009-11-06
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