A5061562408- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Advanced DC-DC Converters
- Genomics and Chromatin Dynamics
- HVDC Systems and Fault Protection
- COVID-19 and healthcare impacts
- Management of metastatic bone disease
- Kidney Stones and Urolithiasis Treatments
- IL-33, ST2, and ILC Pathways
- Molecular spectroscopy and chirality
- GABA and Rice Research
- Extracellular vesicles in disease
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Polydiacetylene-based materials and applications
- Technical Engine Diagnostics and Monitoring
- ATP Synthase and ATPases Research
- Phagocytosis and Immune Regulation
- Power System Optimization and Stability
- Monoclonal and Polyclonal Antibodies Research
Wuhan University
2025
Jining Medical University
2024
Fuzhou University
2024
Sichuan University
2020-2024
West China Hospital of Sichuan University
2024
Affiliated Hospital of Jining Medical University
2015-2024
Materials Science & Engineering
2024
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials
2022-2023
Beihang University
2023
Donghua University
2022-2023
Abstract Lung adenocarcinoma (LUAD) and squamous carcinoma (LUSC) are two major subtypes of non-small cell lung cancer with distinct pathologic features treatment paradigms. The heterogeneity can be attributed to genetic, transcriptional, epigenetic parameters. Here, we established a multi-omics atlas, integrating 52 single-cell RNA sequencing 2342 public bulk sequencing. We investigated their differences in genetic amplification, cellular compositions, expression modules. revealed that LUAD...
Alternative polyadenylation increases transcript diversities at the 3' end, regulating biological processes including cell differentiation, embryonic development and cancer progression. Here, we present a Bayesian method SCAPE, which enables de novo identification quantification of (pA) sites single-cell level by utilizing insert size information. We demonstrated its accuracy robustness identified 31 558 from 36 mouse organs, 43.8% (13 807) were novel. illustrated that APA isoforms...
Novel strategies to facilitate tumor-specific drug delivery and restore immune attacks remain be developed overcome the current limitations of chemotherapy. Herein, a cancer cell membrane (CM)-camouflaged ultrasmall iron oxide nanoparticles (USIO NPs)-loaded polyethylenimine nanogel (NG) system is reported co-deliver docetaxel (DTX) CD47 siRNA (siCD47). The prepared co-delivery exhibits good colloidal stability, biocompatibility, r1 relaxivity (1.35 mM-1 s-1 ) enables redox-responsive...
In the lifecycle of microorganisms, prolonged starvation is prevalent and sustaining life during periods a vital task. literature, it commonly assumed that survival kinetics starving microbes follows exponential decay. This assumption, however, has not been rigorously tested. Currently, clear under what circumstances this assumption true. Also, known when such deviates from decay if deviates, underlying mechanisms for deviation are. Here, to address these issues, we quantitatively...
Abstract Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 in pregnancy remains be determined, evidence indicates that risk factors for severe COVID-19 similar general population. Here we systemically analyzed clinical characteristics pregnant and non-pregnant female patients who were hospitalized during same period found developed marked lymphopenia higher inflammation evident by C-reactive protein IL-6. To elucidate pathways might...
Enhancers can act as cis-regulatory elements to control transcriptional regulation by recruiting DNA-binding transcription factors (TFs) in a tissue-specific manner. Recent studies show that enhancers regulate not only protein-coding genes but also microRNAs (miRNAs), and mutations within the TF binding sites (TFBSs) located on will cause variety of diseases such cancer. However, comprehensive resource integrate these for revealing regulations context is currently available. Here, we...
Turbofan engines are known as the heart of aircraft. The turbofan’s health state determines aircraft’s operational status. Therefore, equipment monitoring and maintenance engine is an important part ensuring healthy stable operation aircraft, it vital to monitor remaining useful life (RUL) engine. monitored data turbofan have high dimensions a long time span, which cause difficulties in predicting This paper proposes residual prediction model based on Autoencoder Temporal Convolutional...
Open AccessRenewablesREVIEWS30 Oct 2024Polymer-Based Electrolyte for Lithium-Based High-Energy-Density and Safe Energy Storages Devices: Strategy Mechanisms Chenke Tang†, Leyang Yu†, Qinkai Jiang†, Rongmeng Gu, Yiming Zhang, Ziqi Liu, Wenlong Cai, Hao Wu, Yun Zhang Meng Yao Tang† , Yu† Jiang† Gu Liu Cai Wu *Corresponding authors: E-mail Address: [email protected] https://doi.org/10.31635/renewables.024.202400068 SectionsAboutAbstractPDF ToolsAdd to favoritesDownload CitationsTrack Citations...
We investigated the link between epigenome-wide methylation aberrations at birth and genomic transcriptional changes upon allergen sensitization that occur in neonatal dendritic cells (DC) due to maternal asthma. previously demonstrated neonates of asthmatic mothers are born with a functional skew splenic DCs can be seen even allergen-naïve pups convey allergy responses normal recipients. However, minimal-to-no or phenotypic were found explain this alteration. Here we provide in-depth...
Background: Enhancers can act as cis-regulatory elements (CREs) to control development and cellular function by regulating gene expression in a tissue-specific ubiquitous manner.However, the regulatory network characteristic of different types enhancers (e.g., transcribed/non-transcribed enhancers, tissue-specific/ubiquitous enhancers) across multiple tissues are still unclear.Results: Here, total 53,924 active 10,307 enhancer-associated RNAs (eRNAs) 10 (adrenal, brain, breast, heart, liver,...
Abstract Both poly(A) enrichment and ribosomal RNA depletion are commonly used for sequencing. Either has its advantages disadvantages that may lead to biases in the downstream analyses. To better access these effects, we carried out both RNA-depleted poly(A)-selected RNA-seq CD4 + T naive cells isolated from 40 healthy individuals Blueprint Project. For individuals, genomic epigenetic data were also available. This dataset offers a unique opportunity understand how library construction...
Recent studies have indicated that long non-coding RNAs (lncRNAs) and mRNA function as competing endogenous (ceRNAs) compete to bind shared microRNA (miRNA) recognition elements (MREs) perform specific biological functions during tumorigenesis.The tumor suppressor p53 is a master regulator of cancer-related processes by acting transcription factor regulate target genes including miRNA lncRNA.However, the mechanism in human hepatocellular carcinoma whether p53-mediated RNA targets could form...
Antibodies are widely used both in clinical practice and research. However, the development of methods to increase ratio antibodies recognize phosphorylated proteins remains challenging. In this study, we report a novel useful method for efficient production proteins. Based on our previously developed vaccine adjuvant Nap-GDFDFDY, prepared hydrogels by Ca2+-induced self-assembly peptide gelator Nap-GDFDFpDY. The hydrogel could protect antigens from being dephosphorylated endogenous...
The purpose of this study was to investigate the effects astragalus polysaccharides (APS) on proliferation and apoptosis bone marrow mesenchymal stem cells (BMSCs) induced by X-ray radiation-induced A549 bystander effect (RIBE), explore their mechanisms. In study, APS increased reduced cell rate RIBE inhibiting cells. terms mechanism, up-regulates proteins Bcl-2, Bcl-xl, down-regulates Bax Bak, which induces a decrease in mitochondrial membrane potential, release Cyt-c AIF, leads...
Alternative splicing is widespread throughout eukaryotic genomes and greatly increases transcriptomic diversity. Many alternative isoforms have functional roles in developmental processes are precisely temporally regulated. To facilitate the study of a context, we created MeDAS, Metazoan Developmental Splicing database. MeDAS an added-value resource that re-analyses publicly archived RNA-seq libraries to provide quantitative data on events as they vary across time course development. It has...
Acting as a sequence-specific transcription factor, p53 tumor suppressor involves in variety of biological processes after being activated by cellular stresses such DNA damage. In recent years, microRNAs (miRNAs) have been confirmed to be regulated several cancer types. However, it is still unclear how miRNAs orchestrate their regulation and function network activation hepatocellular carcinoma (HCC). this study, we used small RNA sequencing systematic bioinformatic analysis characterize the...
Background: The bZIP gene family plays roles in biotic and abiotic stress, secondary metabolism, other aspects plants. They have been reported Arabidopsis thaliana, Oryza sativa, Artemisia annua, plants, but their Cannabis sativa not determined. Materials Methods: In this study, we analyzed the genome-wide identification expression profile of C. sativa. Results: A total 51 members were identified based on genome numbered order from CsbZIP1 to CsbZIP51. Their phylogenetic relationships,...
Recently, cell-based immunotherapy has become one of the most promising ways to completely eliminate cancer. The major challenge is effectively promote a proper immune response kill cancer cells by activated T cells. This study investigated effect cell-mediated trigged Au DENPs-MPC (zwitterion 2-methacryloyloxyethyl phosphorylcholine (MPC)-functionalized dendrimer-entrapped gold nanoparticles) loading oli-godeoxynucleotides (ODN) unmethylated cytosine guanine dinucleotide (CPG). Here, we...
Manipulating gene expression is crucial for understanding function, with high-throughput sequencing techniques such as RNA-seq elucidating the downstream mechanisms involved. However, lack of a standardized metadata format small-scale perturbation datasets in public repositories hinders their reuse. To address this issue, we developed PerturbAtlas, an add-value resource that re-analyzes publicly archived libraries to provide quantitative data on expression, transcript profiles, and...