A5050281823- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Single-cell and spatial transcriptomics
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Biofuel production and bioconversion
- Ubiquitin and proteasome pathways
- Bioinformatics and Genomic Networks
- Lung Cancer Research Studies
- Chemical Synthesis and Analysis
- Medicinal Plants and Bioactive Compounds
- Genetic Associations and Epidemiology
- Biochemical Analysis and Sensing Techniques
- Renal cell carcinoma treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Phytochemistry and Bioactive Compounds
- Heat shock proteins research
- Calcium signaling and nucleotide metabolism
- DNA and Biological Computing
Southwest Jiaotong University
2015-2024
Chinese General Hospital College of Nursing and Liberal Arts
2024
Chinese People's Liberation Army
2024
Shandong Agricultural University
2022-2023
Panyu District Central Hospital
2023
Eastern Hepatobiliary Surgery Hospital
2022
Second Military Medical University
2022
Sichuan University
2011-2012
State Key Laboratory of Biotherapy
2011
Gannan Medical University
2008
Tissue-specific miRNAs (TS miRNA) specifically expressed in particular tissues play an important role tissue identity, differentiation and function. However, transcription factor (TF) TS miRNA regulatory networks across multiple have not been systematically studied. Here, we manually extracted 116 investigated the network of TF-TS 12 human tissues. We identified 2,347 relations revealed that most TF binding sites tend to enrich close start site miRNAs. Furthermore, found were regulated...
Abstract Extrachromosomal circular DNA (eccDNA) represents a large category of non-mitochondrial and non-plasmid extrachromosomal DNA, playing an indispensable role in various aspects such as tumorigenesis, immune responses. However, the information characteristics functions about eccDNA is fragmented, hiding behind abundant literatures massive whole-genome sequencing (WGS) data, which has not been sufficiently used for identification eccDNAs. Therefore, establishing integrated repository...
Doxorubicin (DOX) is a potent available antitumor drug; however, its clinical use limited by the cardiotoxicity. Salidroside (SLD), with strong antioxidative and cytoprotective actions, of particular interest in development therapies for oxidative injury cardiac diseases. Now, protection underlying mechanisms SLD against DOX-induced cardiotoxicity are still unknown. In present study, we revealed both mechanism Bcl2-dependent survival signaling involved SLD's protection. We observed that DOX...
Enhancers can act as cis-regulatory elements to control transcriptional regulation by recruiting DNA-binding transcription factors (TFs) in a tissue-specific manner. Recent studies show that enhancers regulate not only protein-coding genes but also microRNAs (miRNAs), and mutations within the TF binding sites (TFBSs) located on will cause variety of diseases such cancer. However, comprehensive resource integrate these for revealing regulations context is currently available. Here, we...
Despite autophagy's pivotal role in the replication of viruses such as duck Tembusu virus (DTMUV), which has caused massive economic losses to poultry industry world, specific relationships between DTMUV and cellular autophagy remain largely unknown. In response, we investigated interactions DTMUV, effects structural non-structural proteins on autophagy, autophagy-related signaling pathways induced by DTMUV. Among results, increased flux embryo fibroblasts (DEF) BHK-21 cells, while...
Background: Enhancers can act as cis-regulatory elements (CREs) to control development and cellular function by regulating gene expression in a tissue-specific ubiquitous manner.However, the regulatory network characteristic of different types enhancers (e.g., transcribed/non-transcribed enhancers, tissue-specific/ubiquitous enhancers) across multiple tissues are still unclear.Results: Here, total 53,924 active 10,307 enhancer-associated RNAs (eRNAs) 10 (adrenal, brain, breast, heart, liver,...
Recent studies have indicated that long non-coding RNAs (lncRNAs) and mRNA function as competing endogenous (ceRNAs) compete to bind shared microRNA (miRNA) recognition elements (MREs) perform specific biological functions during tumorigenesis.The tumor suppressor p53 is a master regulator of cancer-related processes by acting transcription factor regulate target genes including miRNA lncRNA.However, the mechanism in human hepatocellular carcinoma whether p53-mediated RNA targets could form...
Abstract Precise quantification of the JAK2V617F mutation using highly sensitive assays is crucial for diagnosis, treatment process monitoring, and prognostic prediction in myeloproliferative neoplasms' (MPNs) patients. Digital droplet polymerase chain reaction (ddPCR) enables precise low-level mutations amidst a high percentage wild type alleles without need external calibrators or endogenous controls. The objective this study was to optimize ddPCR assay detecting establish it as...
Acting as a sequence-specific transcription factor, p53 tumor suppressor involves in variety of biological processes after being activated by cellular stresses such DNA damage. In recent years, microRNAs (miRNAs) have been confirmed to be regulated several cancer types. However, it is still unclear how miRNAs orchestrate their regulation and function network activation hepatocellular carcinoma (HCC). this study, we used small RNA sequencing systematic bioinformatic analysis characterize the...
ACEII transcription factor plays a significant role in regulating the expression of cellulase and hemicellulase encoding genes. Apart from ACEII, factors such as XYR1, CRE1, HAP2/3/5 complex ACEI function coordinated pattern for gene cellulases hemicellulases. Studies have demonstrated that deletion results decreased total xylanase activities with reduced transcript levels lignocellulolytic enzymes.In this study, we successfully transformed Trichoderma reesei to significantly improve its...
Infectious serositis is a common disease caused by Riemerella anatipestifer (R. anatipestifer) in ducks, characterized respiratory distress, septicemia, and neurological symptoms. In this study, 1,020 samples (brain liver) were collected from ducks with suspected R. infection March 2020 to 2022 Shandong Province, of which 171 strains identified PCR isolation culture. The serotype all was analyzed, 74 subjected drug sensitivity tests resistance genes detection. results showed that the overall...
Chronic kidney disease (CKD) has a worldwide prevalence of higher than 10% with an increasing mortality rate. As it involves the deterioration renal function, represents serious risk to human health and, if left untreated, significantly lowers quality patient's life. CKD is characterized by fibrosis. Studies have shown that transforming growth factor β1 (TGF‑β1), key driving fibrosis, closely related activation fibrosis pathways such as endoplasmic reticulum stress (ERS)....
Pyrotinib is a novel irreversible tyrosine kinase inhibitor targeting the human epidermal growth factor receptor (HER), whose efficacy in treating metastatic HER2-positive (HER2+) breast cancer has been confirmed. The present study aimed to explore efficacy, safety and prognostic factors of pyrogenic-involved neoadjuvant therapy patients with HER2+ cancer. A total 49 who received pyrotinib-neoadjuvant were recruited. All pyrotinib plus chemotherapy or without trastuzumab treatment for six...