A5102962125- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Spine and Intervertebral Disc Pathology
- Cell Adhesion Molecules Research
- Musculoskeletal pain and rehabilitation
- S100 Proteins and Annexins
- Sexual function and dysfunction studies
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Remote Sensing in Agriculture
- Cancer-related gene regulation
- Hormonal and reproductive studies
- Tissue Engineering and Regenerative Medicine
- RNA Research and Splicing
- Shoulder Injury and Treatment
- Cancer Cells and Metastasis
- Bone Tissue Engineering Materials
- Remote Sensing and Land Use
- Genomics and Chromatin Dynamics
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Remote Sensing and LiDAR Applications
Nanjing Traditional Chinese Medicine Hospital
2021-2025
Nanjing University of Chinese Medicine
2018-2025
Sichuan University
2021-2025
West China Hospital of Sichuan University
2021-2025
University of South China
2017-2024
Shandong University
2018-2024
Jiangsu Provincial Academy of Traditional Chinese Medicine
2021-2024
Weihai Science and Technology Bureau
2024
First Affiliated Hospital of University of South China
2017-2023
Tianjin Medical University
2022
Abstract Purpose: We assessed whether perioperative circulating tumor DNA (ctDNA) could be a biomarker for early detection of molecular residual disease (MRD) and prediction postoperative relapse in resected non–small cell lung cancer (NSCLC). Experimental Design: Based on our prospective, multicenter cohort dynamic monitoring ctDNA surgery patients (LUNGCA), we enrolled 950 plasma samples obtained at three time points (before surgery, 3 days 1 month after surgery) 330 stage I–III NSCLC...
We describe a simple method for bone engineering using biodegradable scaffolds with mesenchymal stem cells derived from human induced-pluripotent (hiPS-MSCs). The hiPS-MSCs expressed markers (CD90, CD73 and CD105), possessed multipotency characterized by tri-lineages differentiation: osteogenic, adipogenic chondrogenic lost pluripotency – as seen the loss of OCT3/4 TRA-1-81 tumorigenicity. However, these iPS-MSCs are still positive marker NANOG. further explored osteogenic potential in...
Abstract Introduction Previously, we established a simple method for deriving mesenchymal stem cells (MSCs) from human induced pluripotent (iPSC-MSCs). These iPSC-MSCs were capable of forming osteogenic structures in scaffolds and nanofibers. The objective this study is to systematically characterize the characteristics by comparing them bone marrow-derived MSCs (BM-MSCs). Methods Two iPSC-MSC lines (named as mRNA-iPSC-MSC-YL001 lenti-iPSC-MSC-A001) one BM-MSC line used study. Cell...
Lumbar disc degeneration due to annulus fibrosus (AF) defects poses a significant challenge in clinical treatment Current treatments exhibit limited repair efficacy and high recurrence rate. To address this, we devised novel approach of crosslinking stabilization strategy. We integrated fibrinogen, thrombin, genipin, human bone marrow-derived mesenchymal stem cells (hBMSCs) hydrogel (FTGB) with acellular scaffold fascia (FTGB@S@F) remediate AF defects. FTIR analysis confirmed stable chemical...
Mechanical neck pain (MNP) is often associated with changes in cervical sagittal alignment, causing and functional limitations. This study evaluated the additional effects of manipulation patients MNP undergoing retraction exercise. Patients were randomly assigned to either plus exercise group (CM + NRE) or (NRE). Both groups completed their respective regimens over an 8-week period. Primary outcomes include visual analogue scale (VAS) range motion (CROM). Secondary disability index (NDI),...
Abstract Background Circulating tumor DNA (ctDNA) is valuable for detecting minimal residual disease (MRD). However, studies involving long-term blood sampling are required to comprehensively interpret the clinical use of ctDNA analyses. Methods We conducted a prospective multicenter cohort study (LUNGCA) dynamic monitoring in lung cancer patients receiving curative-intent surgery. analysis was on preoperative plasma samples, at postoperative three days and one month, then every three–six...
Enhancers can act as cis-regulatory elements to control transcriptional regulation by recruiting DNA-binding transcription factors (TFs) in a tissue-specific manner. Recent studies show that enhancers regulate not only protein-coding genes but also microRNAs (miRNAs), and mutations within the TF binding sites (TFBSs) located on will cause variety of diseases such cancer. However, comprehensive resource integrate these for revealing regulations context is currently available. Here, we...
<h2>Summary</h2> Lung adenocarcinoma is a type of cancer that exhibits wide range clinical radiological manifestations, from ground-glass opacity (GGO) to pure solid nodules, which vary greatly in terms their biological characteristics. Our current understanding this heterogeneity limited. To address gap, we analyze 58 lung patients via machine learning, single-cell RNA sequencing (scRNA-seq), and whole-exome sequencing, identify six multicellular ecotypes (LMEs) correlating with distinct...
This study aimed to explore the possible benefits of adrenomedullin (ADM) in preventing oxidative stress and inflammation by using an vitro primary culture model rat Leydig cells exposed lipopolysaccharide (LPS). Cell proliferation was detected through CCK-8 BrdU incorporation assays. ROS were determined with a DCFDA kit, cytokine concentrations measured ELISA assay kits. Protein production examined immunohistochemical staining Western blot, gene expression observed RT-qPCR. Results revealed...
Background The Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)‐anchored protein. Increasing evidence has indicated PSCA plays an important role in tumorigenesis. However, its function and the underlying molecular mechanisms prostate cancer (PCa) are still not fully elucidated. In this study, we aimed to explore effect of on cycle PCa cells mechanism research. Methods Immunohistochemistry, quantitative reverse transcription‐PCR (qRT‐PCR) Western blotting were used...
Intracavernous pressure (ICP) measurement is a well-established technique for assessing the erectile function, which was performed by cannulating either crus or shaft of penis. However, there are no studies concerning experimental performance two cannulation sites yet. The aim this study to compare measuring outcomes using different sites. To validate capacity our study, both normal and castration-induced dysfunction rat models were conducted. Fifty adult male Sprague-Dawley rats randomized...