A5101475416- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- RNA Research and Splicing
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive Physiology in Livestock
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Oral Health Pathology and Treatment
- Prostate Cancer Treatment and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine regulation and behavior
The University of Sydney
2009-2025
National Health and Medical Research Council
2025
Chengdu Women's and Children's Central Hospital
2019-2025
Chengdu Medical College
2023-2025
Qingdao University
2024
Maternal and Child Health Hospital of Sichuan Province
2021-2024
Xinjiang Medical University
2019-2024
First Affiliated Hospital of Xinjiang Medical University
2024
Jilin University
2014-2023
Changchun University
2023
Splicing regulation is an important step of post-transcriptional gene regulation. It a highly dynamic process orchestrated by RNA-binding proteins (RBPs). RBP dysfunction and global splicing dysregulation have been implicated in many human diseases, but the vivo functions most RBPs outcome upon their loss remain largely unexplored. Here we report that constitutive deletion Rbm17, which encodes with putative role splicing, causes early embryonic lethality mice its Purkinje neurons leads to...
Rap1 GTPase-activating protein (Rap1GAP) is an important tumor suppressor. The purpose of this study was to investigate the role Rap1GAP in myocardial infarction (MI) and its potential mechanism. Left anterior descending coronary artery ligation performed on cardiac-specific conditional knockout (Rap1GAP-CKO) mice control with MI. Seven days after MI, expression hearts peaked, proapoptotic markers (Bax cleaved caspase-3) increased, antiapoptotic factors (Bcl-2) decreased, inflammatory IL-6...
728 Background: Gemcitabine (GEM) plus nab-paclitaxel (NAB-PAC) is a standard first-line chemotherapy regimen for advanced/metastatic pancreatic ductal adenocarcinoma (PDAC), with median Progression Free Survival (mPFS) and Overall (mOS) of 5.5 & 8.7 in the MPACT trial 5.6 9.2 months (mo) NAPOLI 3 trial, respectively. Certepetide (formerly LSTA1 or CEND-1) novel cyclic peptide that improves targeted penetration co-administered drugs into tumor stroma, leading to potentially increased...
The risk of preterm birth (PTB) is associated with maternal hyperglycemia but differs by combinations abnormal oral glucose tolerance test (OGTT) values. However, the potential pathway which affects PTB unclear. This study aimed to investigate association between OGTT-related measures and evaluate mediation effect gestational weight gain (GWG) on in women diabetes mellitus (GDM). retrospective cohort included GDM from a women's children's hospital Chengdu, China, December 2021 2023....
Bone morphogenetic protein-15 (BMP15) is a maternal gene necessary for mammalian reproduction. BMP15 expression increased in oocytes accompanied by follicle growth and development. The function regulation mechanism of porcine cumulus cell apoptosis process still unclear now.In this study, flow cytometry (FCM) was used to analyze the effects with different concentrations apoptosis. High-throughput sequencing technology carried out screen regulatory genes linked closely BMP15. In order confirm...
Background: Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are members of the transforming beta (TGF-β) superfamily. Through autocrine paracrine mechanisms, these two factors can regulate cell differentiation, proliferation, other functions in ovary locally. Furthermore, GDF9 BMP15 play vital roles follicular growth, atresia, ovulation, fertilization, reproduction, maintenance. Numerous studies have demonstrated a synergy between GDF9. Studies humans mice...
Cardiac hypertrophy, as a response to hemodynamic stress, is associated with cardiac dysfunction and death, but whether hypertrophy itself represents pathological process remains unclear. Hypertrophy driven by changes in myocardial gene expression that require the MEF2 family of DNA-binding transcription factors, well nuclear lysine acetyltransferase p300. Here we used genetic small-molecule probes determine effects preventing acetylation on adaptation stress. Both nonacetylatable mutants...
Background/Aims: Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), which are secreted by oocytes, important regulators of follicular development ovarian function. These two factors can regulate the proliferation apoptosis cumulus cells via modulation Smad signaling pathway. Studies have shown that BMP15 GDF9 affect level miR-375, whereas target gene miR-375 is BMPR2, type II receptor GDF9. However, whether or how BMP15/ GDF9-miR-375-BMPR2 pathway affects...
Abstract Objective To investigate whether plasma lipid profiles are independently associated with pregnancy complications including gestational diabetes mellitus (GDM), hypertensive disorder complicating (HDCP), and intrahepatic cholestasis of (ICP). Study Design A prospective study was conducted among 1,704 pregnant women at three medical institutions in Chengdu, China. The concentrations triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), high-density (HDL-C) were...
Diabetic nephropathy (DN) is one of the most frequent complications associated with type I and II diabetes mellitus. Kidneys from patients DN are characterized by mesangial matrix expansion increased thickness glomerular basement membrane, which induced reactive oxygen species (ROS) production. Previous studies have been conducted to investigate this; however, detailed mechanism progression remains be elucidated. The present study evaluated expression antisense mitochondrial non-coding RNA-2...
Adipocyte, the main cellular component of white adipose tissue, plays a vital role in energy balance higher eukaryotes. In recent years, adipocytes have also been identified as major endocrine organ involved immunological responses, vascular diseases, and appetite regulation. farm animals, fat content categories are closely correlated with meat quality. MicroRNAs (miRNAs), class endogenous single-stranded non-coding RNA molecules, participate regulation adipocyte differentiation adipogenesis...
Long noncoding RNAs (LncRNAs) are involved in the occurrence and progression of human tumors including ovarian cancer (OC). RNA HOTTIP has been found to be several development. However, role OC
Abstract Background Nerves are key factors in prostate cancer (PCa) progression. Here, we propose that neuropeptide Y (NPY) nerves regulators of cancer–nerve interaction. Methods We used vitro models for NPY inhibition studies and subsequent metabolomics, apoptotic migration assays, nuclear transcription factor‐κB (NF‐κB) translocation studies. Human naïve radiated PCa tissues were nerve density biomarker Tissues derived from a Botox denervation clinical trial to corroborate metabolomic...
Objective: Interleukin-6 (IL-6) and its receptor complex participate in a number of critical biological activities through several signaling pathways. Placental dysfunction increased inflammation are believed to underlie the pathogenesis severe preeclampsia (PE), which may involve IL-6-induced signaling. We investigate whether changes expression IL-6 cognate receptors, (IL-6R) glycoprotein (gp)130, occur between early late onset PE. Methods: A total 18 healthy gravidas 41 preeclamptic women...
Hypoxia-inducible factor-1α (HIF-1α) is a major effector in cell survival response to hypoxia, while the roles of HIF-1α radiation-induced autophagy are still unclear breast cancer cells. Human carcinoma MCF-7 cells were stably transfected with pSUPER-shRNA against human or scrambled sequence no homology mammalian genes, named as pSUPER-HIF-1α and pSUPER-SC, respectively. Cell Counting Kit-8 (CCK-8) assay colony formation used detect viability, Western blot was protein expression,...
Follicle-stimulating hormone (FSH) secreted by adenohypophyseal cells plays an important role in the regulation of reproduction, but whether microRNAs (miRNAs) regulate secretion FSH remains unclear. In present study, we predicted and screened miRNAs that might act on follicle-stimulating beta-subunit (FSHb) gene rats using TargetScan program luciferase reporter assays, results identified two miRNAs, miR-21-3p miR-433. We then transfected these into rat anterior assessed FSHb expression...