A5022123528- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- Cardiovascular Function and Risk Factors
- SARS-CoV-2 and COVID-19 Research
- Genomics and Chromatin Dynamics
- Signaling Pathways in Disease
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Obstructive Sleep Apnea Research
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Cardiovascular and Diving-Related Complications
- COVID-19 and healthcare impacts
- Acute Myocardial Infarction Research
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Animal Virus Infections Studies
- Virology and Viral Diseases
- CAR-T cell therapy research
- Nitric Oxide and Endothelin Effects
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
Deyang Stomatological Hospital
2025
University of Southern California
2012-2024
Nanjing Medical University
2024
Rockefeller University
2022-2023
Children's Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Zhejiang University
2022
Beijing Anzhen Hospital
2009-2022
Capital Medical University
2009-2022
Union Hospital
2020-2021
Many studies have shown that tumor-associated macrophages (TAMs) contribute to tumor development and poor prognosis in various cancers. In this study, we investigated the macrophage populations phenotypes, their correlation angiogenesis, immunosuppression, clinical intrahepatic cholangiocarcinoma (ICC). CD68 (+) CD163 infiltration was analyzed paraffin-embedded tissue samples from 39 patients. is used as a marker of M2 macrophages. Neovascularization forkhead box P3 (FOXP3) regulatory T...
The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between treatment with Qingfei Paidu decoction (QFPDD) favorable clinical outcomes. In this retrospective multicenter study, we included 782 patients (males, 56 %; median age 46) confirmed COVID-19 from 54 hospitals nine provinces China, who were divided into four groups according...
Attenuation of a virulent virus is proven approach for generating vaccines but can be unpredictable. For example, synonymous recoding viral genomes attenuate replication sometimes results in pleiotropic effects that confound rational vaccine design. To enable specific, conditional attenuation viruses, we examined target RNA features zinc finger antiviral protein (ZAP) function. ZAP recognized CpG dinucleotides and targeted CpG-rich RNAs depletion, such as numbers, spacing surrounding...
Viruses employ a variety of strategies to escape or counteract immune responses, including depletion cell surface major histocompatibility complex class I (MHC-I), that would ordinarily present viral peptides CD8+ cytotoxic T cells. As part screen elucidate biological activities associated with individual severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) proteins, we found ORF7a reduced MHC-I levels by approximately fivefold. Nevertheless, in cells infected SARS-CoV-2, were even...
Periodontal disease is a widespread inflammatory condition that compromises the supporting structures of teeth, potentially resulting in tooth loss if left untreated. Despite advancements therapeutic interventions and an enhanced understanding its pathophysiology, emerging techniques such as single-cell RNA sequencing (scRNA-seq) Mendelian randomization (MR) present new opportunities for precision medicine management periodontal disease. Data derived from GSE152042 dataset underwent rigorous...
The zinc finger antiviral protein (ZAP) depletes nonself RNAs through recognition of their elevated CpG dinucleotide content. dinucleotides are sparse in most endogenous mammalian mRNAs, but a subset might potentially be modulated by ZAP. While frequency alone is insufficient to predict ZAP-regulation, we developed an algorithm using experimentally determined compositional features which mRNAs may ZAP-regulated. Using ZAP-knockout mice, demonstrate that levels many host algorithmically...
Enzymes that modify the epigenetic status of cells provide attractive targets for therapy in various diseases. The therapeutic development modulators, however, has been largely limited to direct targeting catalytic active site conserved across multiple members an enzyme family, which complicates mechanistic studies and drug development. Class IIa histone deacetylases (HDACs) are a group enzymes depends on interaction with Myocyte Enhancer Factor-2 (MEF2) their recruitment specific genomic...
Cardiac hypertrophy, as a response to hemodynamic stress, is associated with cardiac dysfunction and death, but whether hypertrophy itself represents pathological process remains unclear. Hypertrophy driven by changes in myocardial gene expression that require the MEF2 family of DNA-binding transcription factors, well nuclear lysine acetyltransferase p300. Here we used genetic small-molecule probes determine effects preventing acetylation on adaptation stress. Both nonacetylatable mutants...
The number of coronavirus disease 2019 (COVID-19) cases has exceeded 10 million. However, little is known about the epidemiology and clinical characteristics COVID-19 infants. We collected medical information 46 confirmed patients (<1 year old) retrospectively analyzed epidemiological history, symptoms, laboratory test results. median age was 5 (interquartile range, 2-7) months. Sixteen had fever 27 cough. Moderate present in 40 cardiac injury occurred 38 cases, following by liver...
The encapsidation of HIV-1 gRNA into virions is enabled by the binding nucleocapsid (NC) domain Gag polyprotein to structured viral RNA packaging signal (Ψ) at 5’ end genome. However, subcellular location and oligomeric status during initial Gag-Ψ encounter remain uncertain. Domains other than NC, such as capsid (CA), may therefore indirectly affect recognition. To investigate contribution domains Ψ recognition in a cellular environment, we performed protein-protein crosslinking protein-RNA...
Class A scavenger receptors (SR‐A, CD204) are highly expressed in tumor‐associated macrophages (TAM). To investigate the function of SR‐A TAM, wild‐type and SR‐A‐deficient (SR‐A −/− ) mice were injected with EL4 cells. Although these groups did not differ numbers infiltrating lymphocytes neovascularization, had delayed growth tumors. Expression inducible nitric oxide (NO) synthase interferon (IFN)‐γ mRNA increased significantly tumor tissues from mice. Engulfment necrotic cells induced...
Myocyte enhancer factor-2B (MEF2B) has the unique capability of binding to its DNA target sites with a degenerate motif, while still functioning as gene-specific transcriptional regulator. Identifying targets is crucial given regulatory roles exerted by members MEF2 family and MEF2B's involvement in B-cell lymphoma. Analyzing structural data SELEX-seq experimental results, we deduced sequence shape determinants MEF2B on high-throughput basis vitro for wild-type mutant proteins. Quantitative...
Objective: To investigate the prevalence of sleep quality and post-traumatic stress disorder (PTSD) symptoms healthcare workers (HCWs) identify determinants for PTSD among HCWs in high-risk low-risk areas during COVID-19 outbreak China. Methods: The Pittsburgh Sleep Quality Index Impact Event Scale were used to assess 421 Chinese HCWs, respectively, from January 30 March 2, 2020. influencing factors identified by univariate analysis multiple regression. Results: incidence getting 13.2%. had...
Abstract The inflammation-based Glasgow Prognostic Score (GPS), which involves C-reactive protein and serum albumin levels, has been reported to be a strong independent predictor of mortality in many cancers. This study aimed investigate whether the GPS is associated with patients acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI). In this study, 406 consecutive STEMI at our emergency department (ED) who were pPCI...
The treatment of advanced triple-negative breast cancer, which failed in first-line or second-line therapy, is a significant challenge. We conducted this retrospective study to explore the efficacy and safety apatinib capecitabine as third-line for cancer. This involved 44 cancer patients who therapy Tangshan People's Hospital from January 2016 February 2017. Twenty-two received capecitabine, while 22 were treated with monotherapy therapy. progression-free survival (PFS), objective response...
Background The Geriatric Nutritional Risk Index (GNRI), based on serum albumin levels and body index, is a simple nutrition-related risk assessment instrument. Objective We aimed to evaluate the prognostic value of GNRI in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Methods retrospectively analyzed in-hospital long-term adverse outcomes 786 STEMI. Patients were divided into 2 groups their score (≤98 vs >98)....
Since December 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has rapidly engulfed the world. Cancer patients infected with COVID-19 are considered to carry higher severity of and mortality rate than common in previous studies. However, due poor clinical information on cancer, evidences that supported this conclusion insufficient. At present, rather limited reports have analyzed data breast cancer COVID-19. Therefore, retrospective...
Background: At present, the epidemic of novel coronavirus disease 2019 (COVID-19) has quickly engulfed world. Inflammatory cytokines are associated with severity and outcomes patients COVID-19. However, prognostic value pro-inflammatory factors in cancer COVID-19 unknown. Methods: A multi-center, retrospective, cross-sectional study, based on five designated tertiary hospitals for treatment Hubei Province, China. 112 COVID-19, 105 without were enrolled study between January 1st, 2020 April...
The purpose of this study was to examine the expression and actions parathyroid hormone-related protein (PTHrP) when skeletal histogenesis occurs in chicken mandible. Prior appearance tissues, PTHrP PTH1R were co-expressed by cells ectoderm, muscle, peripheral nerve mesenchyme. Hyaline cartilage first observed at HH stage 27 many but not all chondroblasts expressed PTH1R. By 34, detected chondrocytes perichondrium. Alkaline phosphatase (AP)-positive preosteoblasts woven bone appeared stages...
The three-finger proteins are a collection of disulfide bond rich great biomedical interests. Scalable recombinant expression and purification bioactive is quite difficult. We introduce working pipeline for expression, validation disulfide-bond using E. coli as the host. With this pipeline, we have successfully obtained highly purified α-Βungarotoxin, k-Bungarotoxin, Hannalgesin, Mambalgin-1, α-Cobratoxin, MTα, Slurp1, Pate B etc. Milligrams to hundreds milligrams three finger were within...