A5051700748- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Silk-based biomaterials and applications
- Invertebrate Immune Response Mechanisms
- Insect Utilization and Effects
- Viral Infectious Diseases and Gene Expression in Insects
- Silkworms and Sericulture Research
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Insect and Arachnid Ecology and Behavior
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Protein Hydrolysis and Bioactive Peptides
- Studies on Chitinases and Chitosanases
- Biochemical and Structural Characterization
- Poxvirus research and outbreaks
- Cytokine Signaling Pathways and Interactions
- Insect symbiosis and bacterial influences
- Bioinformatics and Genomic Networks
- Herpesvirus Infections and Treatments
- Genomics and Phylogenetic Studies
- COVID-19 and healthcare impacts
Southwest University
2016-2025
Robert Bosch (Germany)
2024
State Key Laboratory of Silkworm Genomic Biology
2012-2023
BGI Group (China)
2004-2023
Shandong Provincial QianFoShan Hospital
2023
Shandong First Medical University
2023
Anhui University of Traditional Chinese Medicine
2016-2022
Wenzhou Medical University
2022
Metamagnetics (United States)
2022
National University of Singapore
2012-2014
We report a draft sequence for the genome of domesticated silkworm (Bombyx mori), covering 90.9% all known genes. Our estimated gene count is 18,510, which exceeds 13,379 genes reported Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities differences in content.
The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between treatment with Qingfei Paidu decoction (QFPDD) favorable clinical outcomes. In this retrospective multicenter study, we included 782 patients (males, 56 %; median age 46) confirmed COVID-19 from 54 hospitals nine provinces China, who were divided into four groups according...
This study aimed at exploring dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides from silkworm pupae proteins by in silico analysis and vitro assessments. In of 274 proteomes indicated that DPP-IV can be released proteins. assessments revealed pepsin bromelain led to better production protein. Notably, peptide fractions (<1 kDa) pepsin- bromelain-treated hydrolysates exhibited more potent activities. Two novel (Leu-Pro-Pro-Glu-His-Asp-Trp-Arg Leu-Pro-Ala-Val-Thr-Ile-Arg) were identified...
The silkworm Bombyx mori is a lepidopteran insect with four developmental stages: egg, larva (caterpillar), pupa, and adult. hemolymph of the in an open system that circulates among all organs, functions nutrient hormone transport, injury, immunity. To understand intricate mechanisms metamorphosis, from different stages, including 3rd day fifth instar, 6th pupation, 8th pupal stage first moth stage, was investigated by two-dimensional electrophoresis mass spectrometry.Two-dimensional...
Long non‑coding RNAs (lncRNAs) are a novel group of that associated with inflammation and tumorigenesis. At present, the diagnostic efficacy lncRNAs in inflammatory bowel disease (IBD) is unclear. The present study aimed to identify may be used as potential biomarkers for IBD. mRNA expression levels various (KIF9‑AS1, LINC01272 DIO3OS) were detected tissue plasma samples from patients IBD by reverse transcription‑quantitative polymerase chain reaction. results indicated KIF9‑AS1...
This study comprehensively evaluates the expression of UXS1 gene and its clinical significance immunological characteristics in various cancers through systematic pan-cancer analysis. used a variety open databases bioinformatics tools to deeply analyze patterns, mutations, features, prognostic relevance different tumors. At same time, relationship between immune cell infiltration, tumor mutation burden (TMB), microsatellite instability (MSI), checkpoint was discussed. The results showed that...
Before metamorphosis, most holometabolous insects, such as the silkworm studied here, undergo a special phase called wandering stage. Insects in this stage often display enhanced locomotor activity (ELA). ELA is vital because it ensures that insect finds safe and suitable place to live through pupal The physiological mechanisms of behavior are still unclear. Here, we integrated proteomics metabolomics approaches analyze brain lepidopteran insect, silkworm, at feeding stages. Using LC-MS/MS...
The head, which performs many biological functions, is the most complicated structure of an insect. Development, locomotor behavior, food intake, environmental sensing, and signal transduction are all controlled by insect's head. As a well-studied insect in Lepidoptera, silkworm head has additional function spinning silk fibers. To understand molecules involved these physiological activities, we performed metabolomics analysis heads. By integrating GC-MS LC-MS/MS, 90 metabolites were...
Animal behaviour regulation is a complex process involving many factors, and the nervous system an essential factor in this process. In species, pathogens can alter host by affecting host's system. An interesting example that silkworm shows enhanced locomotor after being infected with nucleopolyhedrosis virus. study, we analysed transcriptome of brain at different time points infection found various genes related to changed infection. In-depth analysis showed tyrosine hydroxylase gene might...
Abstract A group of lipoproteins with molecular sizes approximately 30 kDa, referred to as 30K proteins, are synthesized in fat body cells the fifth instar larvae silkworm, Bombyx mori. Analyzing silkworm genome and its expressed sequence tags (ESTs), we found 10 genes encoding which mainly distributed three subfamilies. Of these, seven coding proteins were harbor degrading sites 30kP protease A, although number may be different. As some potential core promoters regulatory elements supposed...
The silkworm is a lepidopteran insect that has an open circulatory system with hemolymph consisting of blood and lymph fluid. Hemolymph not only considered as depository nutrients energy, but it also plays key role in substance transportation, immunity response, proteolysis. In this study, we used LC-MS/MS to analyze the proteins four developmental stages during metamorphosis. A total 728 were identified from second day wandering stage, first pupation, ninth adult moth. GO annotations...
The insect cuticle plays important roles in numerous physiological functions to protect the body from invasion of pathogens, physical injury and dehydration. In this report, we conducted a comprehensive genome-wide search for genes encoding proteins with peritrophin A-type (ChtBD2) chitin-binding domain (CBD) silkworm, Bombyx mori. One these genes, which encodes protein BmCBP1, was additionally cloned, its expression location during process development molting B. mori were investigated....
Chitin deacetylases (CDAs) are a group of enzymes involved in chitin metabolism insects; they play critical role molting, pupation, and the modification chitin. In this study, we identified several CDAs silkworm,