A5101509611- Cardiac Arrest and Resuscitation
- Pancreatitis Pathology and Treatment
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Frailty in Older Adults
- COVID-19 and Mental Health
- Acute Myocardial Infarction Research
- Appendicitis Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Nanopore and Nanochannel Transport Studies
- Monoclonal and Polyclonal Antibodies Research
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Nutrition and Health in Aging
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Viral gastroenteritis research and epidemiology
- Cardiac Imaging and Diagnostics
- Renal function and acid-base balance
Sichuan University
2016-2025
Tianjin People's Hospital
2025
Xian Yang Central Hospital
2025
Beijing University of Chinese Medicine
2025
West China Hospital of Sichuan University
2015-2024
Shanghai Ocean University
2024
Hong Kong Polytechnic University
2024
Hunan Agricultural University
2024
State Key Laboratory of Biotherapy
2018-2023
Second Military Medical University
2021-2023
The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public health. virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme consisting an exoribonuclease (ExoN) domain and methyltransferase (MTase) plays pivotal role in viral replication. Here, we report the structure nsp14-ExoN bound its co-factor nsp10 show that, compared SARS-CoV nsp10/nsp14-full-length complex, retains integral fold preserves active configuration catalytic center. Analysis...
Abstract Background Malnutrition is associated with a high risk of mortality in adults ischemic stroke (IS). This study aimed to investigate the relationship between malnutrition and stroke-associated pneumonia (SAP) as only few studies examined SAP IS. Methods Patients were included from emergency departments five tertiary hospitals REtrospective Multicenter for Ischemic Stroke Evaluation (REMISE) January 2020 December 2020. was defined according Controlling Nutritional Status (CONUT),...
The ratio of C-reactive protein to albumin, as a novel inflammation-based prognostic score, is associated with outcomes in cancer and septic patients. diagnostic accuracy the CRP/albumin has not been assessed colorectal surgery for postoperative complications. A total 359 patients undergoing major between 2012 2015 were eligible this study. Uni- multivariate analyses performed identify risk factors Receiver operating characteristic curves developed examine cutoff values CRP levels. Among all...
In December 2019, several patients with pneumonia of an unknown cause were detected in Wuhan, China. On 7 January 2020, the causal organism was identified as a new coronavirus, later named 2019 novel coronavirus (2019-nCoV). Genome sequencing found genetic sequence 2019-nCoV homologous to that severe acute respiratory syndrome-associated coronavirus. As 29 virus had been diagnosed more than 7000 China and 77 other countries. It is reported both symptomatic asymptomatic can play role disease...
Background Global public health is seriously threatened by the escalating issue of antimicrobial resistance (AMR). Antimicrobial peptides (AMPs), pivotal components innate immune system, have emerged as a potent solution to AMR due their therapeutic potential. Employing computational methodologies for prompt recognition these indeed unlocks fresh perspectives, thereby potentially revolutionizing drug development. Methods In this study, we developed model named deepAMPNet. This model, which...
SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 can therefore function as a decoy. Here we show that mutations S19W, T27W, and N330Y in could individually enhance S-RBD binding. Y330 be synergistically combined with either W19 or W27, whereas W27 are mutually unbeneficial. The structures bound the mutants reveal enhanced binding is mainly contributed by van der Waals...
Products of lipolysis released during digestion positively affect the metabolism newborns. In contrast to 3-layer biological membranes covering human milk (HM) fat, lipid droplets in infant formula (IMF) are covered by a single membrane composed casein and whey proteins. To reduce differences structure between IMF HM, studies have used fat globule (MFGM) components such as polar lipids (MPL) prepare emulsions mimicking HM globules However, few elucidated effect proteins (MemP) on infants....
Objective: To investigate white matter microstructure and spontaneous cerebral activity in early neurosyphilis using tract-based spatial statistics amplitude of low-frequency fluctuation (ALFF). Methods: Twenty patients with 20 matched healthy controls underwent diffusion tensor imaging resting-state blood oxygen level-dependent imaging. Neuropsychological tests were performed before each magnetic resonance Fractional anisotropy (FA), mean diffusivity (MD), ALFF values compared between the 2...
Background Observational studies have shown a significant association between immune cells and heart failure (HF). Nevertheless, the precise biological mechanisms underlying this remain unclear. Methods To investigate causative relationships cell traits adult HF, 3 main methods of Mendelian randomization were used: 2‐sample randomization, multivariable with controlling for several factors affecting mediation analysis. Results from inverse variance‐weighted model indicated that genetic...
The interfacial properties of lipid droplets are crucial for infant digestion, yet few studies have explored the impact layers on digestion. In this study, four emulsions were prepared: one with milk polar lipids (MPL) serving as monolayer interface droplet (ME-PL), MPL and membrane-specific protein (MSP) co-monolayer (ME-Co), liposome featuring bilayer (BE-PL), proteoliposome containing MSP co-bilayer (BE-Co). Cryo-TEM was used to determine number layers, while confocal laser scanning...
A high level of liver fat content (LFC) is a key indicator steatotic disease (SLD), reflecting its pathological essence. Periodontal (PD) recognized as chronic inflammatory condition and cause widespread adverse health impact. This study aims to investigate the relationship between PD LFC development. In UK Biobank, were gathered through digital questionnaire, including gum pain, bleed, or teeth loose. was measured by Fatty Liver Index (>60 indicates SLD) in cross-sectional analysis magnetic...