A5101927979- Circular RNAs in diseases
- Research in Cotton Cultivation
- RNA regulation and disease
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Heat shock proteins research
- melanin and skin pigmentation
- Animal Genetics and Reproduction
- Cystic Fibrosis Research Advances
- Immune Response and Inflammation
- Biochemical Analysis and Sensing Techniques
- Advanced biosensing and bioanalysis techniques
- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Retinoids in leukemia and cellular processes
- Berberine and alkaloids research
- Congenital heart defects research
- Climate Change and Health Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cannabis and Cannabinoid Research
- Tracheal and airway disorders
- Milk Quality and Mastitis in Dairy Cows
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Tianjin University of Science and Technology
2014-2025
Sichuan University
2020-2024
West China Hospital of Sichuan University
2020-2021
First Affiliated Hospital of GuangXi Medical University
2016-2020
Guangxi Medical University
2012-2020
Zhengzhou University
2017
Xian Center for Disease Control and Prevention
2017
Sichuan Cancer Hospital
2015
Liaocheng University
2014
Chinese Academy of Agricultural Sciences
2012
<b><i>Aim:</i></b> The aim of this study is to explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and clinicopathological features in patients with papillary thyroid carcinoma (PTC). <b><i>Methods:</i></b> We performed an analysis 843 patients, including 321 PTC, 83 adenoma 439 nodular goiter (NG). Thyroglobulin thyrotropin were measured each patient. Neutrophils, lymphocytes, platelets counted. Statistical was used correlate...
Background . Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations. Macrolide has been shown to exhibit anti-inflammatory effects in some chronic diseases. Objective To assess the efficacy of roxithromycin on inflammation remodeling patients with NCFB under steady state. Methods The study involved an open-label design 52 eligible Chinese NCFB, who were assigned control (receiving no treatment) 150 mg/day for 6 months) groups. At...
A series of sulfanilamide-1,2,3-triazole hybrids were designed by a molecular hybridization strategy and evaluated for antiproliferative activity against three selected cancer cell lines (MGC-803, MCF-7 PC-3). The detailed structure-activity relationships these investigated. All exhibited moderate to potent all lines. In particular 4-methyl-N-((1-(3-phenoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide (11f) showed the most inhibitory effect PC-3 cells, with an IC50 value 4.08 μM....
Background: There has been considerable concern about the potential harmful effects of radiation exposure inducing cancers. However, a few researches focused on biological effect below background (BBR) in deep underground environment. To better understand BBR cancer, we selected well-differentiated laryngeal squamous cell carcinoma (FD-LSC-1) to observe laboratory (DUGL). Methods: The growth curve, morphology and quantitative proteomics were performed FD-LSC-1 cells cultured DUGL aboveground...
Dendritic cells and CD8 + T participate in the pathology of chronic obstructive pulmonary disease, including emphysema, but little is known involvement CD40/CD40L pathway. We investigated role pathway Tc1 cell differentiation induced by dendritic a mouse model vitro. C57BL/6J wild-type CD40 −/− mice were exposed to cigarette smoke (CS) or not (control), for 24 wk. In vitro experiments involved treated with CS extract (CSE) not. Compared control groups, (both wild type ) had greater...
Abstract The aim of the present study was to reveal physical symptom changes and their correlations with mental health status in deep underground miners. A total 286 miners completed a cross-sectional questionnaire at China Pingmei Shenma mine complex. included sociodemographics, self-reported symptoms, adverse environmental factors, Symptom Checklist-90-Revised (SCL-90-R). Five parameters 1 were also measured. Data from 266 valid questionnaires analyzed. 3 most frequent complaints about...
To explore the epidemiological, phylogeographic, and migration characteristics of human rabies in Shaanxi province, China from 2009 to 2015. The collected data were described sequenced glycoprotein (G) nucleoprotein (N) genes implemented estimate evolutionary rates phylogeographic patterns using BEAST v.1.8.2. A total 269 cases reported 70.26% male 61.71% between ages 19-59. majority farmers (83.27%). estimated rate N was 2.4 × 10-4 substitutions/site/year G 3.4 . time most recent common...
Heat acclimation (HA) is an evolutionarily conserved trait that enhances tolerance to novel stressors by inducing heat shock proteins (HSPs). However, the molecular mechanisms underlying this phenomenon remain elusive. In study, we established a HA mouse model through intermittent stimulation. Subsequently, was evaluated using array of physiological and histological assessments.
Abstract As resources in the shallow depths of earth exhausted, people will spend extended periods time deep underground space. However, little is known about environment affecting health organisms. Hence, we established both laboratory (DUGL) and above ground (AGL) to investigate effect environmental factors on Six parameters were monitored DUGL AGL. Growth curves recorded tandem mass tag (TMT) proteomics analysis performed explore proliferative ability differentially abundant proteins...
Cigarette smoke is a major effector of chronic obstructive pulmonary disease (COPD), and Th17 cells dendritic (DCs) involve in the pathogenesis COPD. Previous studies have demonstrated anti-inflammatory effects macrolides. However, macrolides on cigarette extract- (CSE-) induced immune response are unclear. Accordingly, this study, we evaluated erythromycin (EM) CSE-exposed DCs polarizing naïve CD4+ T into cells. were generated from bone marrow-derived mononuclear isolated male BALB/c mice...
Background: Prior studies have shown that the proliferation of V79 lung fibroblast cells could be inhibited by low background radiation (LBR) in deep underground laboratory (DUGL). In current study, we revealed further molecular changes performing whole transcriptome analysis on expression profiles long non-coding RNA (lncRNA), messenger (mRNA), circular (circRNA) and microRNA (miRNA) cultured for two days a DUGL. Methods: Whole including lncRNA, mRNAs, circ miRNA was performed DUGL above...
Aquaporin 7 (AQP7) gene as a candidate Antifreeze was investigated and associated with fresh frozen semen quality traits in 45 Simmental Charolais bulls. PCR-SSCP, PCR-RFLP, sequencing method were employed to detect the single nucleotide polymorphisms (SNPs) of AQP7 gene. Two mutations, A264G G371C, identified. The allele frequencies A (0.97, 0.96) B (0.03, 0.04) C 0.91) D 0.09) bulls, respectively. substitution significantly acrosome integrity ratio (P < 0.01) motility 0.05) semen....
Herpes simplex virus type 2 (HSV-2) was the major cause of genital herpes in humans. The HSV-2 glycoprotein D (gD2) had been proved to be a potentially effective vaccine for treatment herpes. present study develop two step culture express recombinant gD2 protein using immobilized Spodoptera frugiperda (Sf9) cells. first step, Sf9 cells were cultured and harvested eutrophic medium containing 10% fetal bovine serum. second silk fibroin hydrogel stirred-tank bioreactor after infection by...
GO analysis of 739 Ssbp3 specific genes compared with DEGs induced by Gata3 or Cdx2 overexpression. The significantly enriched terms are strongly related to embryonic skeletal system development and pattern specification process. (TIF 78 kb)