A5101970528- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Reproductive System and Pregnancy
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Disease Management and Epidemiology
- Prenatal Screening and Diagnostics
- Galectins and Cancer Biology
- Viral Infections and Immunology Research
- Fungal and yeast genetics research
- Virology and Viral Diseases
- Metal Extraction and Bioleaching
- Flavonoids in Medical Research
- Fungal Biology and Applications
- Nanoporous metals and alloys
- Hepatitis B Virus Studies
- Corrosion Behavior and Inhibition
- Trypanosoma species research and implications
- Atherosclerosis and Cardiovascular Diseases
- Chemical Synthesis and Characterization
- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Invertebrate Immune Response Mechanisms
Anhui University of Traditional Chinese Medicine
2023
Shanghai Maritime University
2022
Hainan University
2011-2022
Taian City Central Hospital
2013-2021
Hanzhong People's Hospital
2021
Shandong Provincial Hospital
2015
Shandong University
2015
Hangzhou Center for Disease Control and Prevention
2012
Tongji Hospital
2011
Chinese Academy of Medical Sciences & Peking Union Medical College
2011
Abstract Background Human cytomegalovirus (HCMV) is the most common pathogen in uterus during pregnancy, which may lead to some serious results such as miscarriage, stillbirth, cerebellar malformation, fetus developmental retardation, but its pathogenesis has not been fully explained. The hypofunction of extravillous cytotrophoblast (EVT) invasion essential pathologic base complications pregnancy. c-erbB-2 a kind oncogene protein and closely linked with embryogenesis, tissue repair...
Coxsackievirus A4 (CVA4) infection can cause hand, foot and mouth disease (HFMD), an epidemic illness affecting neonatal paediatric cohorts, which develop to severe neurological with high mortality. In this study, we established the first ICR mouse model of CVA4 for evaluation inactivated vaccines antiviral drug screening. The YT226R strain was selected infect mice three infectious factors were optimized establish model. 3-day-old exhibited clinical symptoms such as hind limb paralysis...
Abstract Background Human cytomegalovirus (HCMV) infection in utero is very common during pregnancy, which can lead to adverse outcomes both pregnancy and progeny, but its pathogenesis has not been fully clarified. The decrease of extravillous cytotrophoblasts (EVT) invasion an essential pathophysiological process some complications. Hippo-YAP signaling pathway plays important role regulating cell proliferation apoptosis. However, whether YAP involved HCMV uterine remains be studied. Methods...
Background: N6-methyladenosine (m6A) is a prevalent post-transcriptional modification presented in messenger RNA (mRNA) of eukaryotic organisms. Chronic glomerulonephritis (CGN) characterised by excessive proliferation and insufficient apoptosis human glomerular mesangial cells (HGMCs) but its underlying pathogenesis remains undefined. Moreover, the role m6A CGN poorly understood. Methods: The total level was detected using quantification assay (Colorimetric). Cell assessed EdU cell assay,...
Trichophyton rubrum (T. rubrum) is a common superficial fungus. Molecular and genetic studies of T. are still limited. In this paper, we report the global analysis gene expression profiles at different growth phases using cDNA microarray technology. A total 2044 differentially expressed genes were obtained clustered into three patterns. Our data confirmed previous results that many mRNAs pre-stored in conidia rubrum. Transcriptional profiling function showed some glycolytic enzymes share...
This paper aimed to evaluate whether human cytomegalovirus (HCMV) infection in extravillous cytotrophoblasts (EVT) could shift the balance between regulatory T (Treg) and T-helper type 17 (Th17) cells vitro. In this study, primary EVT isolated from first trimester placental tissues were infected with HCMV, conditional media harvested after cultivation for 72 h. lymphocytes cultured presence or absence of HCMV-infected media. The frequencies Th17 Treg HCMV group significantly lower higher...
Herpes simplex virus type 2 (HSV-2) was the major cause of genital herpes in humans. The HSV-2 glycoprotein D (gD2) had been proved to be a potentially effective vaccine for treatment herpes. present study develop two step culture express recombinant gD2 protein using immobilized Spodoptera frugiperda (Sf9) cells. first step, Sf9 cells were cultured and harvested eutrophic medium containing 10% fetal bovine serum. second silk fibroin hydrogel stirred-tank bioreactor after infection by...
Abstract Background : Human cytomegalovirus (HCMV) infection in utero is very common during pregnancy, which can lead to adverse outcomes both pregnancy and progeny, but its pathogenesis has not been fully clear. The decrease of extracellular trophoblast (EVT) invasion an essential pathophysiological process some complications. Hippo-YAP signaling pathway plays important role regulating cell proliferation apoptosis. However, whether YAP involved HCMV uterine remains be studied. Methods...