A5100388765- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Genetics, Aging, and Longevity in Model Organisms
- Animal Genetics and Reproduction
- Uterine Myomas and Treatments
- Renal and related cancers
- Advanced Nanomaterials in Catalysis
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Obesity, Physical Activity, Diet
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Genomics and Chromatin Dynamics
- Heat shock proteins research
- Nutritional Studies and Diet
- Pregnancy and Medication Impact
- CRISPR and Genetic Engineering
- HIV/AIDS drug development and treatment
- Bird parasitology and diseases
- Apelin-related biomedical research
- Mathematical Biology Tumor Growth
- Tissue Engineering and Regenerative Medicine
University of Science and Technology of China
2023-2025
Shandong University
2022-2025
Shandong Women’s University
2024-2025
State Key Laboratory of Reproductive Medicine
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
First Affiliated Hospital of GuangXi Medical University
2019-2024
Guangxi Medical University
2019-2024
Australian Regenerative Medicine Institute
2022
Monash University
2022
Tongren Hospital
2022
Endometriosis is a multifactorial disease associated with inflammation. Vitamin D has anti-inflammatory, antiproliferative, anti-oxidative, and immunomodulatory effects. Whether vitamin levels are correlated endometriosis subject of ongoing debate. This study aimed to examine the association between serum levels. From National Health Nutrition Examination Survey, this examined cross-sectional data American women aged 20-54 years from 2001 2006. After adjusting for covariates, multivariable...
Cerium oxide (CeO
The first cell-fate decision is the process by which cells of an embryo take on distinct lineage identities for time, thus representing beginning developmental patterning. Here, we demonstrate that molecular chaperone heat shock protein A2 (HSPA2), a member 70 kDa (HSP70) family, asymmetrically expressed in late 2-cell stage mouse embryos. knockdown Hspa2 one blastomeres prevented its progeny predominantly toward inner cell mass (ICM) fate. In contrast, overexpression two-cell did not induce...
Recurrent spontaneous abortion (RSA) affects approximately 1-5% of childbearing women and poses a significant threat to global reproductive health. Transfer RNA-derived small RNAs (tsRNAs) are novel class noncoding implicated in various human diseases. However, the role mechanism tsRNAs regulating trophoblast function during RSA development remain unknown. High-throughput sequencing was performed analyze differential villous tissues patients with controls. CCK-8, transwell assay, flow...
Assisted reproductive technology (ART) is used widely and efficiently to treat infertility. During the ART procedure, one of main factors affecting success rate abnormal development preimplantation embryos. The establishment maintenance developmental competence are precisely regulated at different levels, while minor errors early stages may result in adverse outcomes, including arrest implantation failure. As major inputs, regulatory mechanisms metabolites embryonic less known. In this...
The first cell-fate decision is the process by which cells of an embryo take on distinct lineage identities for time, thus representing beginning developmental patterning. Here, we demonstrate that molecular chaperone heat shock protein A2 (HSPA2), a member 70 kDa (HSP70) family, asymmetrically expressed in late 2-cell stage mouse embryos. knockdown Hspa2 one blastomeres prevented its progeny predominantly towards inner cell mass (ICM) fate. In contrast, overexpression did not induce...
A considerable proportion of males suffer from asymptomatic SARS-CoV-2 infection, while the effect on reproductive function and underlying pathomechanisms remain unclear. The total sperm count decreased evidently after yet all semen samples were tested to be RNA negative. Through label‑free quantitative proteomic profiling, a 733 proteins further identified in seminal plasma 11 COVID-19 patients seven uninfected controls. Of 37 differentially expressed proteins, 23 upregulated 14...
Background: Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are members of the transforming beta (TGF-β) superfamily. Through autocrine paracrine mechanisms, these two factors can regulate cell differentiation, proliferation, other functions in ovary locally. Furthermore, GDF9 BMP15 play vital roles follicular growth, atresia, ovulation, fertilization, reproduction, maintenance. Numerous studies have demonstrated a synergy between GDF9. Studies humans mice...
Abstract Background The aim of this retrospective study was to investigate whether oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin dexamethasone) are beneficial for patients repeated implantation failure (RIF) chronic endometritis (CE) improve clinical pregnancy outcomes. Methods Patients RIF CE were diagnosed using hysteroscopy histology together. A total 42 enrolled in the study. All received 22 underwent immediately after end antibiotic...
Abstract Background Invasion of the endometrium by trophoblast cells is a key event during pregnancy, although underlying mechanism remains unclear. Aquaporin 9 (AQP 9) expressed in many eukaryotes and associated with cell invasion. The objective this study was to evaluate significance AQP9 recurrent spontaneous abortion. Methods We screened GSE22490 dataset further differentiated aquaporin expression villi. evaluated as one factors abortion injecting overexpressed plasmid into uterus CD1...
In brief Post-ovulatory aging (POA) results in a decline oocyte quality and embryonic developmental capacity although the underlying mechanisms remain elusive. This study provides comprehensive mRNA expression profiles of fresh oocytes mice for first time. Abstract POA impairs mammalian with harmful effects on potential embryo. is major problem humans since it associated low rate natural fertility, high spontaneous abortion efficiency vitro fertilization. However, molecular this process...
Saving the ovarian function of premature failure (POF) patients undergoing chemotherapy is an important problem in field reproductive medicine. At present, human umbilical cord mesenchymal stem cells (HucMSCs) have been used treatment POF, but effect still not optimal. The purpose this study was to determine whether blood platelet-rich plasma (ucPRP) enhances beneficial effects HucMSCs POF. First, we observed changes biological activity ucPRP on vitro. Subsequently, tracked distribution and...
Abstract Intrauterine adhesions (IUA) are a common gynecological problem. Stem cell therapy has been widely used in the treatment of IUA. However, due to complex and harsh microenvironment uterine cavity, effectiveness such is greatly inhibited. This study aimed investigate whether melatonin pretreatment enhances efficacy human umbilical cord mesenchymal stem cells (HucMSCs) IUA rats. First, we explored effect on biological activity HucMSCs vitro through macrophage co-culture system, Cell...
In mammals, oocytes display compromised quality after experiencing a process of postovulatory aging. However, the mechanisms underlying are not yet fully understood. Here, we portrayed protein expression profile fresh and aging metaphase II (MII) mouse by means four-dimensional label-free quantification mass spectrometry (4D-LFQ).The analysis 4D-LFQ data illustrated that there were seventy-six differentially expressed proteins (DEPs) between two groups MII stage oocytes. Fifty-three DEPs...
<title>Abstract</title> Cerium oxide (CeO<sub>2</sub>) nanospheres have limited enzymatic activity that hinders further application in catalytic therapy, but they an "oxidation switch" to enhance their by increasing oxygen vacancies. In this study, according the defect-engineering strategy, we developed PtCuO<sub>X</sub>/CeO<sub>2 − X</sub> nanozymes as highly efficient SOD/CAT mimics introducing bimetallic Cu and Pt into CeO<sub>2</sub> vacancies, attempt combine near-infrared (NIR)...
Abstract The first cell-fate decision is the process by which cells of an embryo take on distinct lineage identities for time, thus representing beginning developmental patterning. Here, we demonstrate that molecular chaperone heat shock protein A2 (HSPA2), a member 70 kDa (HSP70) family, asymmetrically expressed in late 2-cell stage mouse embryos. knockdown Hspa2 one blastomeres prevented its progeny predominantly toward inner cell mass (ICM) fate. In contrast, overexpression two-cell did...