A5056909137- Phytochemicals and Antioxidant Activities
- Protein Interaction Studies and Fluorescence Analysis
- Natural Antidiabetic Agents Studies
- Collagen: Extraction and Characterization
- Meat and Animal Product Quality
- Cell death mechanisms and regulation
- Nuts composition and effects
- Protein Hydrolysis and Bioactive Peptides
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Bioactive Compounds
- Drug Transport and Resistance Mechanisms
- Nanoparticle-Based Drug Delivery
- Proteins in Food Systems
- Neuroinflammation and Neurodegeneration Mechanisms
- Food composition and properties
- Hemoglobin structure and function
- Bioactive Compounds and Antitumor Agents
- Advanced Glycation End Products research
- Peanut Plant Research Studies
- Berberine and alkaloids research
- Phytochemical Studies and Bioactivities
- Diet, Metabolism, and Disease
- NF-κB Signaling Pathways
- GABA and Rice Research
- Mycotoxins in Agriculture and Food
Shandong University of Technology
2016-2025
Ecologie Microbienne Lyon
2019-2023
Beijing University of Chinese Medicine
2020
Hunan University
2020
Henan Normal University
2019
Guangxi Academy of Sciences
2019
Hunan Cancer Hospital
2017
Central South University
2017
Northwest A&F University
2012-2016
Henan University of Science and Technology
2012-2013
Chicoric acid has been reported to possess various bioactivities. However, the antiobesity effects of chicoric remain poorly understood. In this study, we investigated on 3T3-L1 preadipocytes and its molecular mechanisms apoptosis. inhibited cell viability induced apoptosis in which was characterized by chromatin condensation poly ADP-ribose-polymerase (PARP) cleavage. Mitochondrial membrane potential (MMP) loss, Bax/Bcl-2 dysregulation, cytochrome c release, caspase-3 activation were...
α-Glucosidase is related to the increase in postprandial blood glucose vivo. Inhibition of α-glucosidase supposed be an effective approach treat type 2 diabetes mellitus (T2DM). Trilobatin, a member dihydrochalcone family, shows anti-oxidant, anti-inflammatory and anti-diabetic activities. In this study, inhibitory activity mechanism trilobatin on were investigated using multispectroscopic molecular docking techniques. The kinetic analysis showed that reversibly inhibited noncompetitive-type...
Abstract Raspberry possesses several health benefits such as antitumor, antioxidant, and blood sugar‐regulating activities. In order to improve the use value of raspberries, optimal preparation process raspberry chewable tablets (RCT) its physical, chemical, hypoglycemic properties were investigated in this research. The optimum formulation RCT was determined 39.1% powder, 13.1% red beet root 9.8% corn starch, 15% microcrystalline cellulose, 14% mannitol, 1% magnesium stearate, 8% ethanol...
Kinetics, multispectroscopic methods and molecular simulation were used to investigate the inhibitory activity mechanism of trilobatin on tyrosinase.
Abstract In the present study, antioxidant activities and functional properties of cowhide collagen peptides (CCAPs) with different molecular weight (MW) were investigated. The optimum preparation conditions CCAPs hydrolysis time 1.53 hr, temperature 54.9 °C, pH 7.38, neutral enzyme to trypsin ratio 0.048 g: 0.016 g according single factor test response surface methodology (RSM). Three fractions (CCAP‐I, CCAP‐II, CCAP‐III) obtained by ultrafiltration lyophilization. Antioxidant revealed that...
Human liver cancer has emerged as a serious health concern in the world, associated with poorly available therapies. The Berberis genus contains vital medicinal plants miraculous healing properties and wide range of bioactivities. In this study, different crude extracts B. lycium Royle were prepared screened against Hepatocarcinoma (HepG2) cell lines. water/ethanolic extract (BLE) exhibited significant antiproliferative activity HepG2 line an IC50 value 47 μg/mL. decreased clonogenic...
Liver cancer is one of the most frequent causes cancer-related deaths worldwide. The current study sought to screen, for first time, a Ficus carica variety from Shandong province China against hepatocellular (HepG2) cells. Crude extracts F. with various polarities were prepared and screened HepG2 acetone extract leaf (FLA) exhibited significant antiproliferative effects cells (IC50 = 0.179 mg/mL) while producing least toxicity on normal human umbilical vein endothelial (HUVECs). Biochemical...
Momordin Ic is a natural triterpenoid saponin found in various Chinese and Japanese medicines such as the fruit of Kochia scoparia (L.) Schrad. has been previously demonstrated to induce HepG2 cell apoptosis ROS-mediated PI3K MAPK pathway-dependent manner. In present study, underlying mechanisms pathway-mediated PPARγ, PGC-1α co-regulator activation, well effects downstream proteins, COX-2 FoxO4, on were investigated. The results that momordin activated PPARγ inhibited COX-2. FoxO4...
Eremurus chinensis Fedtch. (ECF) with nutritious roots, belonging to the genus of Eremurus, is a special species grown in China. However, functional properties ECF roots have not been intensely investigated. The antioxidant and anticancer effects ethanol extracts from E. (ECFE) were evaluated present study. ECFE exhibited high radical-scavenging activities on DPPH ABTS radicals, strong reducing power Fe2+-chelating activity. also effectively protected biological macromolecules including...
Inhibition of α-glucosidase activity is a promising method to prevent postprandial hyperglycemia. The inhibitory effect and interaction chrysin diosmetin on were studied in this study. results inhibition kinetics showed that reversibly inhibited with IC50 value 26.445 ± 1.406 μmol L−1 18.380 1.264 L−1, respectively. Further research revealed exhibited mixed-type pattern against α-glucosidase, while was noncompetitive Ki (2.6 0.04) ×10−4 mol L−1. Fluorescence spectroscopy both could quench...
In the present study, antioxidant and anti-human liver cancer (HepG2) cells effects of bioactive peptides from cowhide collagen (BPCC) were evaluated. BPCC exhibited significant scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals ((60.09 ± 3.51)%), 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) ((77.40 3.10)%) hydroxyl ((56.00 2.30)%) as well strong reducing power (0.320 0.025). Meanwhile, effectively protected biomacromolecules including proteins, lipids DNA...