A5045140872- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Corneal surgery and disorders
- Nitric Oxide and Endothelin Effects
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Receptor Mechanisms and Signaling
- Pain Mechanisms and Treatments
- Intraocular Surgery and Lenses
- Neuroscience and Neuropharmacology Research
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Ion channel regulation and function
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Neuropeptides and Animal Physiology
- Ophthalmology and Eye Disorders
- Neuroscience and Neural Engineering
- Thermoregulation and physiological responses
- Corneal Surgery and Treatments
- Veterinary Pharmacology and Anesthesia
- Circadian rhythm and melatonin
- Optical Imaging and Spectroscopy Techniques
- Infrared Thermography in Medicine
Fukuoka International University
2019-2024
International University of Health and Welfare
2019-2024
Akita University
2013-2023
American Academy of Ophthalmology
2017
University of Tsukuba
2011
Xiamen University
2009
Wakayama Medical University
2000-2004
RIKEN Center for Brain Science
2004
Inouye Eye Hospital
2002
Yale University
1990-2001
To elucidate the clinical and epidemiologic characteristics of optic neuritis in Japan.Multicenter cross-sectional, observational cohort study.A total 531 cases unilateral or bilateral noninfectious identified 33 institutions nationwide Japan.Serum samples from patients with were tested for anti-aquaporin-4 antibodies (AQP4-Abs) anti-myelin oligodendrocyte glycoprotein (MOG-Abs) using a cell-based assay correlated findings.Antibody positivity, radiologic characteristics, visual outcome.Among...
Purpose: Posterior subcapsular cataract (PSC) is a frequent complication in patients with retinitis pigmentosa (RP). The risk factors for PSC formation RP are largely unknown. purpose of this study was to investigate the PSC. Methods: We retrospectively studied total 322 eyes 173 who were diagnosed typical RP. considered following possible PSC: age, sex, hypertension, diabetes mellitus, high myopia, asthma, history steroid intake, and aqueous flare. Aqueous flare values measured...
1. The effects of pirenzepine and gallamine on the membrane contractile properties smooth muscle cells excitatory neuro-effector transmission in dog trachea were investigated by means microelectrode, double sucrose gap tension recording methods. 2. Pirenzepine (10(-7) M) (10(-5) had no effect resting potential or input resistance cells. 3. (10(-10)-10(-9) enhanced amplitude twitch contractions evoked field stimulation combined presence indomethacin propranolol (10(-6) M). At higher...
To evaluate the efficacy and safety of ripasudil for treatment secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction received topical 0.4% between 2014 2018 due to three glaucoma subtypes, including uveitic (UG), exfoliation (EG) or steroid-induced (SG) were assessed mean change from baseline prior with ripasudil. We further evaluated each subtype, characteristics cohort, course uveitis-induced...
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Purpose.: Allopregnanolone is a neurosteroid and powerful modulator of neuronal excitability. The neuroprotective effects allopregnanolone involve potentiation γ-aminobutyric acid (GABA) inhibitory responses. Although glutamate excitotoxicity contributes to ganglion cell death in glaucoma, the role GABA glaucoma remains uncertain. aim this study was determine whether synthesis induced by high pressure retina modulates pressure-mediated toxicity. Methods.: Ex vivo rat retinas were exposed...
Purpose: To study lamina cribrosa (LC) depth variation measured by spectral-domain optical coherence tomography (SD-OCT) in four glaucomatous optic disc phenotypes. Methods: In this cross-sectional study, 59 normal eyes and 180 open-angle glaucoma (OAG) were grouped into 56 focally injured discs (FI), 30 generalized enlargement of the cup (GE), 69 myopic (MY), 25 senile sclerotic (SS). They imaged enhanced imaging SD-OCT, obtaining multiple horizontal vertical B-scans. Mean maximum LC depths...
Purpose: Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation RP largely unknown. purpose this study was to investigate the association between aqueous flare, surrogate index intraocular inflammation, and secondary RP. Methods: We retrospectively studied total 206 eyes 117 who were diagnosed typical Aqueous flare values measured consecutively 2012 2013 using laser cell meter. Spectral-domain optical coherence...
Purpose.: High levels of glutamate can be toxic to retinal GCs. Thus, effective buffering extracellular is important in preserving structure and function. GLAST, a major transporter the retina, glutamine synthetase (GS) regulate accumulation prevent excitotoxicity. This study was an examination changes function expression GLAST GS ex vivo rat retinas exposed acute increases ambient pressure. Methods.: Ex were elevated hydrostatic pressure for 24 hours. The examined using immunochemistry...
Purpose: To estimate the prevalence and risk factors for polypoidal choroidal vasculopathy (PCV) in a general Japanese population. Methods: This population-based, cross-sectional study was conducted 2007 with subjects from Hisayama Study. Of 3,648 residents Hisayama, Japan, 2,663 who were ≥ 50 years old enrolled this study. The characteristics of PCV determined by fundus examination or based on indocyanine green fluorescein angiographic findings. We evaluated contributions PCV. Results:...
In the central nervous system, 24(S)-hydroxycholesterol (24(S)-HC) is an oxysterol synthesized from cholesterol by 24-hydroxylase (CYP46A1) encoded cyp46a1 gene. present study using a rat ex vivo glaucoma model, we found that retinal 24(S)-HC synthesis facilitated pressure elevation. Moreover, neuroprotective against mediated degeneration. Quantitative real-time RT-PCR, ELISA, and immunohistochemistry revealed elevated expression of CYP46A1. Immunohistochemically, enhanced CYP46A1 was mainly...
The current study aimed to investigate the time course of changes in choroidal circulation hemodynamics and their relationship systemic dynamics during normal menstrual cycle young, healthy women using laser speckle flowgraphy (LSFG).This prospective included 26 eyes from 13 (21.3 ± 4.0 years) with a 24 12 men (21.8 4.4 as control group. macular mean blur rate (MBR), quantitative index relative blood flow velocity choroid, was measured LSFG. MBR, intraocular pressure (IOP), systolic (SBP),...