A5103089632- Glaucoma and retinal disorders
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Microbial Natural Products and Biosynthesis
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Neurological Disorders and Treatments
- Carbohydrate Chemistry and Synthesis
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Synthesis and Biological Activity
- Retinal Development and Disorders
- Fungal Biology and Applications
- Acute Ischemic Stroke Management
- Ergonomics and Musculoskeletal Disorders
- Heavy Metal Exposure and Toxicity
- Blood groups and transfusion
- Diet and metabolism studies
- Synthetic Organic Chemistry Methods
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
- Ophthalmology and Visual Impairment Studies
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
Kyoto Prefectural University of Medicine
2016-2025
The University of Tokyo
2024
Minamiaoyama Eye Clinic
2020-2024
Yamagata Prefectural University of Health Sciences
2023
Japanese Red Cross Society, Japan
2023
Yamagata Prefectural Institute of Public Health
2020-2021
Matsunami General Hospital
2003-2019
Azabu University
2019
Ophthalmology Associates (United States)
2017
Keio University
1999-2014
OBJECTIVE: Troglitazone was recently reported to specifically promote the differentiation of pre-adipocytes into adipocytes in vitro subcutaneous fat only, indicating a relation insulin-resistance-improving action troglitazone. To expand on this finding, we investigated at clinical level how long-term administration troglitazone influences body distribution type 2 diabetic patients. RESEARCH DESIGN AND METHODS: (400 mg/day) administered for 6 months 30 patients whose glycemic control poor. A...
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is complex disease with significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls replication the most findings in 9173 26 780 across 18 collections Asian, African European descent. Apart from confirming strong evidence association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P 2.81 × 10−33), we observed one SNP showing to (CDC7–TGFBR3 rs1192415,...
Primary open-angle glaucoma (POAG) is the major type of glaucoma. To discover genetic markers associated with POAG, we examined a total 1,575 Japanese subjects in genome-wide association study (stage 1) and subsequent 2). Both studies were carried out at single institution. In stage 1 study, compared SNPs between 418 POAG patients 300 control subjects. First, low-quality data eliminated by stringent filter, 331,838 autosomal selected for analysis. Poorly clustered visual assessment, leaving...
To date, only a small portion of the genetic variation for primary open-angle glaucoma (POAG), major type glaucoma, has been elucidated.We examined our two data sets genome-wide association studies (GWAS) derived from total 2,219 Japanese subjects. First, we performed GWAS by analyzing 653,519 autosomal common single-nucleotide polymorphisms (SNPs) in 833 POAG patients and 686 controls. As result, five variants that passed Bonferroni correction were identified CDKN2B-AS1 on chromosome...
Purpose: The purpose of this study was to evaluate the association between intronic expansion a trinucleotide repeat (TNR) in TCF4 gene and Fuchs' endothelial corneal dystrophy (FECD) Japanese population. Methods: Forty-seven FECD patients 96 age-matched controls were recruited. examined by slit-lamp noncontact specular microscopy. length determined direct sequencing short tandem assay PCR-amplified DNA Southern blotting unamplified DNA. Results: A TNR expansion, defined as >50 CTG repeats...
Background/Aim To train and validate the prediction performance of deep learning (DL) model to predict visual field (VF) in central 10° from spectral domain optical coherence tomography (SD-OCT). Methods This multicentre, cross-sectional study included paired Humphrey analyser (HFA) 10-2 VF SD-OCT measurements 591 eyes 347 patients with open-angle glaucoma (OAG) or normal subjects for training data set. We trained a convolutional neural network (CNN) predicting threshold (TH) sensitivity...
Abstract We aimed to develop a model predict visual field (VF) in the central 10 degrees patients with glaucoma, by training convolutional neural network (CNN) optical coherence tomography (OCT) images and adjusting values Humphrey Field Analyzer (HFA) 24–2 test. The dataset included 558 eyes from 312 glaucoma 90 46 normal subjects. testing 105 72 patients. All were analyzed HFA 10-2 test OCT; additionally 24-2 During CNN training, total deviation (TD) of point predicted combined...
To investigate T cell antigen receptor (TCR) clonotypes in rheumatoid arthritis (RA) lesions.Reverse transcriptase-polymerase chain reaction with TCR V beta family-specific primers and subsequent single-strand conformation polymorphism (SSCP) analysis were performed. Direct nucleotide sequencing was also conducted.A distinct clonal expansion of cells observed the synovium. Furthermore, identical bands samples different areas same lesion obtained by SSCP analysis. Nucleotide revealed that...
To evaluate the efficacy and safety of ripasudil for treatment secondary glaucoma, a historical cohort study was conducted at 18 centres in Japan. Adults (age ≥20 years) who needed additional IOP reduction received topical 0.4% between 2014 2018 due to three glaucoma subtypes, including uveitic (UG), exfoliation (EG) or steroid-induced (SG) were assessed mean change from baseline prior with ripasudil. We further evaluated each subtype, characteristics cohort, course uveitis-induced...
<h3>Importance</h3> Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber eye. This most commonly known cause glaucoma and major irreversible blindness. <h3>Objective</h3> To determine if exfoliation associated with rare, protein-changing variants predicted to impair function. <h3>Design, Setting, Participants</h3> A 2-stage, case-control, whole-exome sequencing association...
The PreserFlo MicroShunt (PMS) is a minimally invasive surgical device for glaucoma management. However, postoperative hypotony remains significant complication. This retrospective cohort study analyzed 471 eyes to evaluate the efficacy of PMS implantation in reducing intraocular pressure (IOP) and medication dependency, as well identify risk factors associated with hypotony. median IOP decreased significantly from 19 mmHg preoperatively 10 three months postoperatively, medications score...
In the course of screening for apoptosis-inducing agents, chloptosin (1) was isolated from culture broth Streptomyces. The dumbbell-type structure dimeric cyclohexapeptide consisting d-valine, (3S)- and (3R)-piperazic acids, O-methyl-l-serine, d-threonine, (2S,3aR,8aR)-6-chloro-3a-hydroxy-2,3,3a,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid elucidated by spectroscopic chemical degradation studies. amino components in each domain were presented alternating R S configurations. Chloptosin...
Potent apoptosis-inducing peptides, polyoxypeptins A (1) and B (2) were isolated from the culture broth of Streptomyces sp. by solvent extraction column chromatography. Structural elucidation 1 MS NMR analyses revealed that it is a cyclic hexadepsipeptide having novel amino acid previously unrecognized N-acyl side chain. The depsipeptide consisted 3-hydroxyleucine, N-hydroxyvaline, N-hydroxyalanine, piperazic acid, 5-hydroxyhexahydropiperazine-3-carboxylic an unusual hitherto unreported...
Recent studies have shown that prostaglandin analogues can decrease the central corneal thickness (CCT), however, most of those followed patient's CCT for only approximately 2 years. The purpose this present study was to perform a long-term follow-up investigation in patients who underwent topical monotherapy over 4 years, and then analyze changes correlation between intraocular pressure (IOP) changes.This retrospective involved 52 eyes glaucoma consulted with specialists at Glaucoma Clinic...