A5050862939- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Patient-Provider Communication in Healthcare
- Atherosclerosis and Cardiovascular Diseases
- Protein Kinase Regulation and GTPase Signaling
- Microbial metabolism and enzyme function
- Ocular Diseases and Behçet’s Syndrome
- Genetic Associations and Epidemiology
- Retinopathy of Prematurity Studies
- Ubiquitin and proteasome pathways
- Protein Tyrosine Phosphatases
- Antioxidant Activity and Oxidative Stress
- Helicobacter pylori-related gastroenterology studies
- Older Adults Driving Studies
- Cellular transport and secretion
- Health, Nursing, Elderly Care
- Genetic Neurodegenerative Diseases
- Ocular Surface and Contact Lens
- Delphi Technique in Research
Moorfields Eye Hospital NHS Foundation Trust
2017-2023
Aristotle University of Thessaloniki
2012-2022
Moorfields Eye Hospital
2015-2022
University College London
2015-2022
National Institute for Health Research
2017-2020
AHEPA University Hospital
2009-2018
Glaucoma Research Foundation
2017
Guy's and St Thomas' NHS Foundation Trust
2014
St Thomas' Hospital
2014
To report on the prevalence of pseudoexfoliation (PEX) and its association with ophthalmic characteristics systemic diseases in a well-defined population.The Thessaloniki Eye study is cross-sectional population-based chronic eye Thessaloniki, Greece. Participants PEX were identified by clinical examination compared those without regards to diseases, after adjusting for age sex.PEX was found 11.9% 2261 clinic-visit participants. PEX, without, had higher intraocular pressure, larger vertical...
<h3>Importance</h3> Exfoliation syndrome is a systemic disorder characterized by progressive accumulation of abnormal fibrillar protein aggregates manifesting clinically in the anterior chamber eye. This most commonly known cause glaucoma and major irreversible blindness. <h3>Objective</h3> To determine if exfoliation associated with rare, protein-changing variants predicted to impair function. <h3>Design, Setting, Participants</h3> A 2-stage, case-control, whole-exome sequencing association...
To investigate the association of two single-nucleotide polymorphisms (SNPs) in lysyl oxidase-like 1 (LOXL1) gene with pseudoexfoliation syndrome (PEX), pseudoexfoliative glaucoma (PEXG), and primary open-angle (POAG) a Greek population-based setting, from Thessaloniki Eye study.A total 233 subjects successful DNA extraction, PCR amplification, genotyping were included genetic analysis G153D R141L SNPs LOXL1 classified into four groups: controls (n = 93); PEX 40); POAG 66); PEXG 34)....
To assess the overdiagnosis of open-angle glaucoma (OAG) and to investigate associated factors.This was a cross-sectional, population-based study an urban Caucasian population in northern Greece. Randomly selected subjects ≥60 years (n = 2554) participated Thessaloniki Eye Study. The definition OAG required presence structural functional damage, irrespective intraocular pressure (IOP). Non-OAG were classified as overdiagnosed with if they had reported at least one following (self-reported...
Purpose: To investigate the association of antihypertensive medications with optic disc structure by blood pressure (BP) level, in nonglaucoma subjects. Design: Cross-sectional, population-based study. Methods: A subset Thessaloniki Eye Study participants was included this Subjects were interviewed for medical history and underwent extensive ophthalmic examination, BP measurement, imaging Heidelberg retinal tomograph. treated hypertension grouped following groups: (1) angiotensin-converting...
Background To investigate the outcomes of glaucoma referrals across different European countries. Methods 250 patients newly referred to tertiary referral specialist practices in UK, Hungary, Slovenia, Italy and Greece were prospectively enrolled (50 consecutive per centre). Referral accuracy predictive value criteria for an intervention or further monitoring (positive value) analysed. Results Same-day discharges occurred 43% (95% CI 39% 75%) (12/28) optometrist-initiated (UK only), 37% 30%...
Purpose: To identify the factors associated with retinal vessel diameters in population of Thessaloniki Eye Study. Methods: Cross-sectional population-based study (age ≥ 60 years). Subjects glaucoma, late age-related macular degeneration, and diabetic retinopathy were excluded from analyses. Retinal measured using IVAN software, measurements summarized to central artery equivalent (CRAE), vein (CRVE), arteriole venule ratio (AVR). Results: The analysis included 1614 subjects. hypertensive...
Purpose: To assess the agreement among three masked examiners on central retinal artery (CRA) and ophthalmic (OA) blood flow velocity measurements performed with colour Doppler imaging (CDI) in healthy volunteers. Methods: The study included 30 eyes of 15 Prior to study, all underwent intensive CDI training by an expert facilitate uniformity performing according a specific protocol. Following eligibility visit, assessing CRA OA both subjects. All images were analysed grader. Intraclass...
Pseudoexfoliation syndrome (PEX) and glaucoma (pseudoexfoliative glaucoma; PEXG, primary open-angle POAG) have mainly been studied for their associations with genes' polymorphisms. The purpose of this exploratory study was to investigate the role polymorphisms in genes encoding micro RNAs (miRNAs) related miRNA biogenesis.In present genetic association study, ninety-two were investigated contribution PEX (n = 203), PEXG 38), POAG 40) pathogenesis compared a control group 188). next...
Background/Aims The goal of health research is to improve patients care and outcomes. Thus, it essential that addresses questions are important clinicians. aim this study was develop a list priorities for glaucoma involving stakeholders from different countries in Europe. Methods We used three-phase method, including two-round electronic Delphi survey workshop. clinician patient surveys were conducted parallel independently. For phase I, the distributed 27 European 6 languages, Glaucoma...
Purpose: To explore the association of two single nucleotide polymorphisms (SNPs) in CX3CR1 gene with grades age-related macular degeneration (AMD) a population-based setting.Methods: The Thessaloniki Eye study is cross-sectional epidemiologic chronic eye diseases Thessaloniki, Greece. A total 371 subjects were included and classified according to their AMD status. Subjects Grades 0–1 (n = 188) compared those 2–3 138), Grade 4 (geographic atrophy) 20) 5 (neovascular AMD) 25) regard presence...
Aims To provide population-based data on the maximum tolerable rate of progression to avoid visual impairment (maxTRoP_VI) and blindness (maxTRoP_BL) from open-angle glaucoma (OAG). Methods Participants with OAG in Thessaloniki Eye Study (cross-sectional, study a European population) were included analysis. Visual was defined as mean deviation (MD) equal or worse than −12dB MD −24dB. Additional thresholds for tested. For each participant maxTRoP_VI which would not lead during expected...