A5102785786- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Microbial metabolism and enzyme function
- SARS-CoV-2 and COVID-19 Research
- Genomics and Phylogenetic Studies
- COVID-19 and healthcare impacts
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Head and Neck Cancer Studies
- Retinal Imaging and Analysis
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Lung Cancer Research Studies
- Microbial Metabolism and Applications
- Biofuel production and bioconversion
- Crystallography and molecular interactions
- Virus-based gene therapy research
- Estrogen and related hormone effects
- Retinal and Optic Conditions
- Fermentation and Sensory Analysis
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Microbial Community Ecology and Physiology
- Mechanical Circulatory Support Devices
University of Tokyo Hospital
2018-2025
National Hospital Organization
2021-2025
National Hospital Organization Saitama Hospital
2021-2025
Kobe University
2023-2024
Rockefeller University
2023-2024
Fukuoka University
2024
AstraZeneca (Japan)
2022-2023
Mount Sinai Beth Israel
2020-2022
Icahn School of Medicine at Mount Sinai
2020-2022
Nihon University
2016-2022
Small-cell lung cancer (SCLC) is a highly aggressive with poor prognosis, due to lack of therapeutic targets. Sulforaphane (SFN) an isothiocyanate derived from cruciferous vegetables and has shown anticancer effects against numerous types cancer. However, its effect SCLC remains unclear. The present study aimed demonstrate the SFN in cells by investigating cell death (ferroptosis, necroptosis caspase inhibition). human lines NCI-H69, NCI-H69AR (H69AR) NCI-H82 normal bronchial epithelial...
Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence cigarette smoke (CS) exposure. Moreover, smoking deposits iron in mitochondria alveolar cells. Iron overload causes Fenton reaction, leading reactive oxygen species (ROS) production, ROS leakage from induces cell inflammation lungs. Nevertheless, mechanisms underlying metabolism are yet be elucidated. In this study, we...
Patients with short telomeres and interstitial lung disease may have decreased chronic allograft dysfunction (CLAD)-free survival following transplantation. The relationship between post-transplant telomere length outcomes transplantation has not been characterised among all recipients, regardless of native disease. This was a single-centre prospective cohort study. Consenting transplant recipients had their measured using quantitative real-time PCR assays on peripheral blood collected at...
Introduction The recently recommended activated clotting time (ACT) to be maintained at the initiation of and during cardiopulmonary bypass (CPB) is ≥480 s. However, post-unfractionated heparin (UFH) administration ACT occasionally does not exceed 480 Therefore, in this study, we retrospectively evaluated factors influencing post-heparin before initiating CPB. Methods In retrospective patients aged <7 years who had undergone open-heart surgery with CPB between August 2021 June 2023 were...
Abstract Background Metastatic castration‐resistant prostate cancer (mCRPC) is a genetically heterogeneous disease with poor prognosis. The prevalence of mutations in homologous recombination repair (HRR) pathway genes, including BRCA1/2 , as well treatment patterns and clinical outcomes, are not characterized among Japanese men mCRPC. Methods This multicenter, noninterventional cohort study enrolled mCRPC from 24 institutions between 2014 2018. Mutations the 15 HRR‐related genes were...
Five strains, NBRC 3271(T), 3272, 3263, 3260 and 3269 were examined genetically, phylogenetically, phenotypically chemotaxonomically. The DNA G+C contents of the five strains 55.1-56.4 mol%. had low levels DNA-DNA hybridization 13-51 % to type Gluconobacter frateurii, thailandicus, oxydans, cerinus, albidus kondonii formed a cluster that was separate from six species given above in phylogenetic trees based on 16S rRNA gene 16S-23S internal transcribed spacer sequences. weakly produced...
Purpose: To evaluate the relationship between skin autofluorescence (SAF), which reflects accumulation of advanced glycation end products (AGEs), and severity diabetic retinopathy (DR) in patients with type 2 diabetes.Methods: Sixty-seven eyes 67 diabetes were enrolled. age-matched non-diabetic subjects served as controls. Diabetic classified by their DR: no DR (NDR), non-proliferative (NPDR), proliferative (PDR). SAF was measured an reader.Results: significantly higher than controls (median...
The taxonomic positions of five bacterial strains isolated from the Yaeyama Islands Japan and 'Microscilla arenaria' NBRC 15982 were determined using a polyphasic approach. 16S rRNA gene sequence analyses placed all close to genus Flammeovirga. DNA-DNA hybridization studies, biochemical physiological characterizations chemotaxonomic suggested that 'M. novel isolates represented two separate species Emendation Flammeovirga Nakagawa et al. 1997 aprica (Reichenbach 1989) is proposed. In...
Asaia lannaensis sp. nov. was described for two strains isolated from flowers of the spider lily collected in Chiang Mai, Thailand. The isolates produced acetic acid ethanol on ethanol/calcium carbonate agar, differing type bogorensis, siamensis, and krungthepensis, but did not grow presence 0.35% (v/v). new species is fourth genus Asaia, family Acetobacteraceae.
Two isolates, AC04T and AC05, were isolated from the flowers of red ginger collected in Chiang Mai, Thailand. In phylogenetic trees based on 16S rRNA gene sequences, two isolates included within a lineage comprised genera Acidomonas, Gluconacetobacter, Asaia, Kozakia, Swaminathania, Neoasaia, Granulibacter, Tanticharoenia, they formed an independent cluster along with type strain Tanticharoenia sakaeratensis. The calculated pair-wise sequence similarities isolate 97.8–92.5% to strains...
Tanticharoenia sakaeratensis gen. nov., sp. nov. is proposed for three strains isolated from soil collected in Thailand. The strains, AC37(T), AC38, and AC39, were included within a lineage comprising the genera Asaia, Kozakia, Swaminathania, Neoasaia, Acetobacter, Gluconobacter, Saccharibacter phylogenetic tree based on 16S rRNA gene sequences, but formed quite different, independent cluster. Pair-wise sequence similarities of strain AC37(T) 96.5-92.1% to type Acetobacter aceti,...
Purpose To test the genetic association between Japanese patients with primary open-angle glaucoma (POAG) and previously reported POAG susceptibility loci to perform genotype–phenotype analysis. Methods Genetic associations for 27 SNPs from 16 linked were assessed using genome-wide SNP data of cohort (565 1,104 controls). Reproducibility assessment was tested in 607 cases 455 controls (second cohort) a targeted genotyping approach. For POAG-associated variants, correlation study (additive,...
We studied the effect of potassium iodide on chemotaxis neutrophil in 15 healthy subjects with a modified Boyden chamber method. Orally administered (15 mg/kg/day for 3 days) significantly inhibited peripheral blood. It is postulated that therapeutic erythema nodosum, nodular vasculitis, and Sweet's syndrome might be mediated through inhibition by this agent.
The taxonomic position of bacterial strain AM11-6(T), isolated from seawater in Japan, was determined by using a polyphasic approach. strictly aerobic and Gram-staining-negative slender rod, motile gliding. major respiratory quinone menaquinone-6 the predominant cellular fatty acids were iso-C(15 : 0), iso-C(17 0) 3-OH, C(14 1) G. polar lipid pattern indicated presence an unidentified phospholipid, several glycolipids lipid. G+C content genomic DNA 36.4 mol%. Phylogenetic analysis based on...
The characteristics of glaucoma patients and their response to therapy may differ by institution, region country. Therefore, clinicians should understand the distinctiveness patients. Here, we profile primary open angle (POAG) normal tension (NTG) at a major university hospital in Japan. This study included 523 eyes from POAG NTG who underwent full clinical ophthalmologic evaluations Tohoku University Hospital. Clinical such as age, sex, visual acuity, intraocular pressure, Humphrey field...
Acute respiratory distress syndrome (ARDS) is a life-threatening disease; however, its treatment has not yet been fully established. The progression of ARDS considered to be mediated by altered intercellular communication between immune and structural cells in the lung. One several factors involved extracellular vesicle (EV). They act as carriers functional content such RNA molecules, proteins, lipids deliver cargo from donor recipient cells. EVs have reported regulate nucleotide-binding...
Abstract DNA topoisomerases are attractive targets for anticancer agents. Dual topoisomerase I/II inhibitors particularly appealing due to their reduced rates of resistance. A number therapeutically relevant bacterial natural products. Mining the untapped chemical diversity encoded by soil microbiomes presents an opportunity identify additional inhibitors. Here we couple metagenome mining, bioinformatic structure prediction algorithms, and synthesis produce dual inhibitor tapcin. Tapcin is a...
Purpose: We investigated in detail the correlation between structure and function macula, whether optical coherence tomography (OCT)-measured macular could be used to simulate visual field.