A5083020720- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genomics, phytochemicals, and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Pediatric health and respiratory diseases
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Redox biology and oxidative stress
- Cell Adhesion Molecules Research
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Cell death mechanisms and regulation
- Regulation of Appetite and Obesity
- Barrier Structure and Function Studies
- Immune Cell Function and Interaction
Nihon University
2016-2025
Nihon University Itabashi Hospital
2019-2024
Keio University
2021
Pulmonary Associates
2021
Riau University
2021
Juntendo University
2021
University School
2021
Respiratory Clinical Trials
2011-2018
National Institute of Environmental Health Sciences
2007-2012
National Institutes of Health
2011-2012
Adiponectin, a novel adipocyte-derived collagen-like protein, is the gene product of adipose most-abundant transcript 1 (apM1), which has been considered to have anti-inflammatory and anti-atherogenic effects.To characterize relationship between adiponectin leptin, ob product, in normal-weight obese women.In this cross-sectional study, we measured fasting plasma by ELISA, leptin concentrations RIA, related parameters such as blood pressure, body mass index (BMI), fat mass, lipids, glucose...
Asthma is a complex heritable disease that increasing in prevalence and severity, particularly developed countries such as the United States, where 11% of population affected. The contribution environmental genetic factors to this growing epidemic currently not well understood. We hypothesis, based on previous literature, changes DNA methylation resulting aberrant gene transcription may enhance risk developing allergic airway disease. Our findings indicate mice, maternal diet supplemented...
Myofibroblasts play an important role in the fibrogenic process of pulmonary fibrosis. Transforming growth factor (TGF)- β is well known to induce phenotypic modulation fibroblasts myofibroblasts; however, intracellular signal regulating induction myofibroblastic phenotype human lung (HLF) has not been determined. In present study, we examined mitogen-activated protein kinase (MAPK) superfamily inducing HLF myofibroblasts characterized by α –smooth-muscle actin expression, order clarify this...
Allergic asthma stems largely from the actions of T helper 2 (Th2) cells, but pathways that initiate Th2 responses to inhaled allergens are not fully understood. In lung, there two major subsets dendritic cells (DCs), displaying CD11b or CD103. We found after taking up ovalbumin in vivo, purified CD103(+) DCs lung lung-draining lymph nodes primed differentiation ex vivo. induction by was also seen when cockroach house dust mite were used. contrast, CD11b(hi) Th1 differentiation. Moreover,...
Small-cell lung cancer (SCLC) is a highly aggressive with poor prognosis, due to lack of therapeutic targets. Sulforaphane (SFN) an isothiocyanate derived from cruciferous vegetables and has shown anticancer effects against numerous types cancer. However, its effect SCLC remains unclear. The present study aimed demonstrate the SFN in cells by investigating cell death (ferroptosis, necroptosis caspase inhibition). human lines NCI-H69, NCI-H69AR (H69AR) NCI-H82 normal bronchial epithelial...
Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence cigarette smoke (CS) exposure. Moreover, smoking deposits iron in mitochondria alveolar cells. Iron overload causes Fenton reaction, leading reactive oxygen species (ROS) production, ROS leakage from induces cell inflammation lungs. Nevertheless, mechanisms underlying metabolism are yet be elucidated. In this study, we...
Abstract Exposure to ozone in air pollution urban environments is associated with increases pulmonary-related hospitalizations and mortality. Because also alters clearance of pulmonary bacterial pathogens, we hypothesized that inhalation modifies innate immunity the lung. To address our hypothesis, exposed C57BL/6J mice either free or ozone, then subsequently challenged an aerosol Escherichia coli LPS. Pre-exposure resulted enhanced airway hyperreactivity, higher concentrations both total...
Th17 cells comprise a distinct lineage of proinflammatory T helper that are major contributors to allergic responses. It is unknown whether cyclooxygenase (COX)-derived eicosanoids regulate during lung inflammation.To determine the role COX metabolites in regulating cell differentiation and function inflammation.COX-1(-/-), COX-2(-/-), wild-type mice were studied an vivo model ovalbumin-induced inflammation vitro using flow cytometry, cytokine assays, confocal microscopy, real-time...
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Inhaled corticosteroids enhance airway epithelial barrier integrity. However, the mechanism by which they accomplish this is unclear. Therefore, we investigated steroid-inducible genes and signaling pathways that were involved in enhancing A human bronchial cell line (16HBE cells) was cultured with 10−6 M dexamethasone (DEX) for 3 days to After measuring transepithelial electrical resistance (TER) paracellular permeability, extracted total RNA from 16HBE cells performed microarray pathway...
Asthma is one of the most common immunological diseases and characterized by airway hyperresponsiveness (AHR), mucus overproduction, eosinophilia. Although mouse models have provided insight into mechanisms which type-2 cytokines induce asthmatic inflammation, differences between rodent human immune systems hamper efforts to improve understanding allergic diseases. In this study, we aim establish a preclinical animal model inflammation using humanized IL-3/GM-CSF or IL-3/GM-CSF/IL-5 Tg...
Abstract Background It remains unclear how to characterize different subtypes of asthma and chronic obstructive pulmonary disease (COPD). We previously described serum periostin chitinase‐3‐like protein 1 (YKL‐40) as useful markers for asthma‐COPD overlap (ACO). MicroRNAs (miRNAs) are now recognized identifying the pathophysiological features in several diseases. This study aimed identify circulating miRNAs that could discriminate patients with ACO from or COPD. Methods included two...