A5035098995- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Pain Management and Opioid Use
- Gallbladder and Bile Duct Disorders
- Chronic Kidney Disease and Diabetes
- Cancer survivorship and care
- Asthma and respiratory diseases
- Nerve injury and regeneration
- Respiratory Support and Mechanisms
- Biochemical Analysis and Sensing Techniques
- Nutrition and Health in Aging
- Cell Adhesion Molecules Research
- Pulmonary Hypertension Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
Nihon University
2015-2024
Shizuoka Cancer Center
2021-2024
Gifu University
2012-2016
Suzuki (Japan)
2007-2015
Ajinomoto (Japan)
2007-2015
Gifu Municipal Hospital
2013
Nagoya City University
2008-2009
University of Toyama
2008
Institute for Molecular Science
2007
The Graduate University for Advanced Studies, SOKENDAI
2007
Small-cell lung cancer (SCLC) is a highly aggressive with poor prognosis, due to lack of therapeutic targets. Sulforaphane (SFN) an isothiocyanate derived from cruciferous vegetables and has shown anticancer effects against numerous types cancer. However, its effect SCLC remains unclear. The present study aimed demonstrate the SFN in cells by investigating cell death (ferroptosis, necroptosis caspase inhibition). human lines NCI-H69, NCI-H69AR (H69AR) NCI-H82 normal bronchial epithelial...
Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence cigarette smoke (CS) exposure. Moreover, smoking deposits iron in mitochondria alveolar cells. Iron overload causes Fenton reaction, leading reactive oxygen species (ROS) production, ROS leakage from induces cell inflammation lungs. Nevertheless, mechanisms underlying metabolism are yet be elucidated. In this study, we...
The prognostic impact of changes in performance status (PS) untreated patients with advanced non-small cell lung cancer (NSCLC) are not clear. This study aimed to evaluate the acute PS deterioration NSCLC. is a single center, retrospective, observational study. Patients Stage IV NSCLC who were referred our institution between January 2018 and March 2023 retrospectively reviewed. divided into three groups: 1) 0 or 1 at referral start chemotherapy; 2) 2 worse initial 3) that deteriorated...
ABSTRACT The capabilities of four white‐rot fungi to improve the digestibility sugarcane bagasse for ruminants were determined. Bagasse was cultured with Lentinula edodes , Pleurotus eryngii salmoneostramineus Ceriporiopsis subvermispora (ATCC 90467) or C. (CZ‐3) at 26°C 8, 12 16 weeks. in vitro organic matter (IVOMD) and neutral detergent fiber (IVNDFD) untreated 45.6 40.3%, respectively. Meanwhile, L. two strains respectively, weeks, elevated 68.6 59.1%, 60.6 49.9% 59.9 49.0%, In contrast,...
Acute respiratory distress syndrome (ARDS) is a life-threatening disease; however, its treatment has not yet been fully established. The progression of ARDS considered to be mediated by altered intercellular communication between immune and structural cells in the lung. One several factors involved extracellular vesicle (EV). They act as carriers functional content such RNA molecules, proteins, lipids deliver cargo from donor recipient cells. EVs have reported regulate nucleotide-binding...
Abstract Background Chemotherapy‐induced anorexia is a common occurrence in patients undergoing treatment for advanced lung cancer. However, the relationship between chemotherapy‐induced and weight loss during platinum‐based chemotherapy combined with immune checkpoint inhibitors unclear. This study explored therapeutic outcomes stage IV non‐small‐cell cancer inhibitors. Methods The retrospectively reviewed medical records of 106 treated January 2019 October 2022. incidence its association...
Abstract Background Adipose tissue induces inflammation, which desensitizes the efficacy of immunotherapy. However, several reports show that therapeutic effect programed cell death 1 (PD‐1)/programed death‐ligand (PD‐L1) inhibitor(s) monotherapy is significantly better in obese patients. Therefore, adipose on immunotherapy unclear. Methods In this study, we retrospectively reviewed patients with advanced non‐small lung cancer (NSCLC) who received PD‐1/PD‐L1 inhibitor between May 2016 and...
Carboplatin plus etoposide is a standard treatment for older extensive-stage small-cell lung cancer (ES-SCLC) patients with performance status (PS) 2. However, often exhibit poor PS (3, 4), and the effect in them poorly understood. To determine therapeutic efficacy safety of carboplatin therapy this population, we retrospectively analyzed 63 ES-SCLC ≥2, aged ≥71 years, who had received first-line therapy. We compared baseline 2 versus those 3-4. In (38 patients) ≥3 (25 groups, overall...
Using a mouse model of advanced skin cancer which has mixed nociceptive-neuropathic pain, we evaluated the analgesic effects morphine and adjuvants. Morphine hydrochloride (10—30 mg/kg, oral) mexiletine intraperitoneal) dose-dependently inhibited thermal hyperalgesia. Baclofen (10 subcutaneous) suppressed hyperalgesia, without at lower doses 1 5 mg/kg. Ketamine (50 was effect. Analgesic tolerance observed after 6th administration morphine, it not developed until least 7th baclofen. This may...
Abstract Background Which patients benefit from the addition of immune checkpoint inhibitors (ICIs) to chemotherapy for small cell lung cancer (SCLC) remains unclear. There have been few reports on efficacy ICIs based conventional immunohistochemical neuroendocrine (NE) markers (synaptophysin, chromogranin A, and neural adhesion molecule [NCAM]). In present study, we aimed analyze relationship between expression NE in with extensive disease (ED)‐SCLC, assess whether are predictive ICIs....
In this study, we examined whether several types of non-opioid agents would inhibit the pain-related responses melanoma-bearing mice. Orthotopic inoculation with melanoma into hind paw induced marked tactile allodynia and mechanical hyperalgesia. A peroral injection (p.o.) gabapentin (100-300 mg/kg) inhibited hyperalgesia, without effects on gross behaviors. An intraperitoneal (i.p.) ketamine hydrochloride (30 produced partial inhibition in hyperalgesia prostate posture at 15 min after...
(‑)‑Epigallocatechin gallate (EGCG) is a major component of green tea. It has been demonstrated that EGCG an antithrombotic effect by inhibiting platelet aggregation. However, the detailed mechanisms underlying effects remain to be elucidated. The present study examined on human activation various stimulators and exact mechanisms. suppressed adenosine diphosphate (ADP)‑stimulated aggregation dose dependently between 30 70 µM. By contrast, failed affect stimulated collagen, U46619 (a TP...