A5082359670- Bone Metabolism and Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Cancer, Hypoxia, and Metabolism
- Bone health and treatments
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Neonatal and fetal brain pathology
- Signaling Pathways in Disease
- Nanoplatforms for cancer theranostics
- Ion Transport and Channel Regulation
- Cytokine Signaling Pathways and Interactions
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Neuroscience and Neuropharmacology Research
- HER2/EGFR in Cancer Research
- Ubiquitin and proteasome pathways
- Thermal Regulation in Medicine
- Mesenchymal stem cell research
Nagoya City University
2014-2024
Future University Hakodate
2024
Mizuho (Japan)
2002-2014
National Institutes of Health
2007-2010
National Institute of Environmental Health Sciences
2010
Chiba Cancer Center
2003
Abstract LIM-only proteins (LMO), which consist of LMO1, LMO2, LMO3, and LMO4, are involved in cell fate determination differentiation during embryonic development. Accumulating evidence suggests that LMO1 LMO2 act as oncogenic T-cell acute lymphoblastic leukemia, whereas LMO4 has recently been implicated the genesis breast cancer. However, little is known about role LMO3 either tumorigenesis or In present study, we have identified HEN2, encodes a neuronal basic helix-loop-helix protein,...
Abstract The hypoxia‐responsive cytokine erythropoietin (EPO) provides neuroprotective effects in the damaged brain during ischemic events and neurodegenerative diseases. purpose of present study is to evaluate EPO/EPO receptor (EPOR) endogenous system between astrocyte oligodendrocyte precursor cell (OPC) under hypoxia. We report here elevated EPO mRNA levels protein release cultured astrocytes following hypoxic stimulation by quantitative RT‐PCR ELISA. Furthermore, EPOR gene expressions...
Localized tumor necrosis factor-alpha (TNFalpha) elevation has diverse effects in brain injury often attributed to signaling via TNFp55 or TNFp75 receptors. Both dentate granule cells and CA pyramidal express TNF receptors (TNFR) at low levels a punctate pattern. Using model induce selective death of (trimethyltin; 2 mg/kg, i.p.), neuronal apoptosis [terminal deoxynucleotidyl transferase-mediated dUTP-biotin situ end labeling, active caspase 3 (AC3)] was accompanied by amoeboid microglia...
M2-like tumor-associated macrophages (M2-TAMs) in cancer tissues are intimately involved immunosuppression addition to growth, invasion, angiogenesis, and metastasis. Hence, considerable attention has been focused on immunotherapies targeting M2-TAMs. However, systemic therapies inhibit TAMs as well other important for normal immune responses throughout the body. To stimulate tumor immunity with fewer side effects, we targeted M2-TAMs using photodynamic therapy (PDT), which damages cells via...
Perinatal hypoxia-ischemia (HI) frequently causes white-matter injury, leading to severe neurological deficits and mortality, only limited therapeutic options exist. The white matter of animal models human patients with HI-induced brain injury contains increased numbers oligodendrocyte progenitor cells (OPCs). However, the origin fates these OPCs their potential repair injured remain unclear. Here, using cell-type- region-specific genetic labeling methods in a mouse HI model, we...
Bone remodeling mediated by bone-forming osteoblasts (OBs) and bone-resorbing osteoclasts (OCs) maintains bone structure function. Excessive OC activation leads to bone-destroying diseases such as osteoporosis erosion of rheumatoid arthritis (RA). Differentiation OCs from marrow cells (BMCs) is regulated the microenvironment. The proinflammatory cytokine interleukin (IL)-1β reportedly enhances osteoclastogenesis plays important roles in RA-associated loss. present study investigated effect...
Objectives. To determine whether aquaporins (AQPs) are expressed in the synovial tissues of patients with OA and RA, to examine patterns expression without hydrarthrosis.
Abstract Bone homeostasis comprises the balance between bone-forming osteoblasts and bone-resorbing osteoclasts (OCs), with an acceleration of osteoclastic bone resorption leading to osteoporosis. OCs can be generated from marrow cells (BMCs) under tightly regulated local environment. However, it remained difficult identify critical responsible for providing osteoclastogenesis niche. In this study, we used a fluorescence-activated cell sorting technique determine populations important...
Brain capillary endothelial cells (BCECs) form the blood-brain barrier (BBB), which is essential for maintaining homeostasis of brain. Net cellular turnover, results from balance between cell death and proliferation, important in BBB homeostasis. Here we report a novel mechanism that underlies ATP-induced proliferation t-BBEC 117, line derived bovine brain cells. Application 0.1-30 mum ATP to 117 concentration-dependently increased intracellular Ca(2+) concentration ([Ca(2+)](i)) two phases:...
Abstract Background Hypoxic-ischemic encephalopathy (HIE) has a high morbidity rate and involves severe neurologic deficits, including cerebral palsy. Therapeutic hypothermia (TH) been shown to decrease the mortality provide neuroprotection in infants with HIE. However, death disability rates HIE treated TH remain high. Although cellular mechanism of neuroprotective effect remains unclear, astrocytic erythropoietin (EPO) is known be key mediator under hypoxic conditions. In present study, we...
Atherosclerosis is a chronic inflammatory disease and the underlying cause of most cardiovascular diseases. Interleukin (IL)-1β facilitates early atherogenic lesion formation by increasing monocyte adhesion to endothelial cells via upregulation molecules, including intercellular molecule-1 (ICAM-1). MicroRNAs (miRNAs) have been shown be associated with conditions in vascular system. The expression circulating miR-1914-5p reportedly downregulated patients However, role downregulation...