A5087110326- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Urinary and Genital Oncology Studies
- Gastroesophageal reflux and treatments
- Inflammatory Bowel Disease
- Ureteral procedures and complications
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Gastrointestinal Tumor Research and Treatment
- Renal cell carcinoma treatment
- Renal and related cancers
- Eosinophilic Esophagitis
- Neuroendocrine Tumor Research Advances
- Autoimmune and Inflammatory Disorders
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Renal and Vascular Pathologies
- Sarcoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Sexual Differentiation and Disorders
- Microscopic Colitis
Nagoya City University
2014-2025
Shizuoka University
2024
University of Calgary
2010-2023
Nagoya City University Hospital
2016-2018
Nagoya Medical Center
2017-2018
Mizuho (Japan)
2013-2017
Osaka University
1968-2014
Kōchi University
2014
Kyoto University
2014
Okayama University of Science
2014
Cisplatin (CDDP) is the most frequently used chemotherapeutic agent for various types of advanced cancer, including gastric cancer. However, almost all cancer cells acquire resistance against CDDP, and this phenomenon adversely affects prognosis. Thus, new agents that can overcome CDDP-resistant will improve survival patients.We synthesized glycoconjugated platinum (II) palladium complexes, [PtCl2 (L)] [PdCl2 (L)]. cell lines were established by continuous exposure to gene expression in was...
Both the pre-apoptotic exposure to calreticulin (CRT) and post-apoptotic release of high-mobility group box 1 protein (HMGB1) are required for immunogenic cell death. Photodynamic therapy (PDT) uses non-toxic photosensitizers visible light at a specific wavelength in combination with oxygen produce cytotoxic reactive species that kill malignant cells by apoptosis and/or necrosis, shut down tumor microvasculature, stimulate host immune system. We have previously shown glycoconjugated chlorin...
Abstract Background: Endoscopic mucosal resection is an established method for treating intramucosal gastric neoplasms. Conventional endoscopic has predominantly been performed using strip biopsy, but local recurrence sometimes occurs due to such piecemeal resection. submucosal dissection recently in Japan new devices as insulation‐tip diathermic knife. The efficacy and problems associated with were evaluated by comparison conventional Methods: Treatment consisted of 48 lesions from January...
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal of gastrointestinal tract. Except for surgical resection, no effective treatment strategies have been established. Photodynamic therapy (PDT) consists intravenous administration a photosensitizer, activated by specific wavelength light, which produces reactive oxygen species that directly kill tumor cells. We analyzed efficacy PDT using newly developed 5,10,15,20-tetrakis...
Background: Fosaprepitant-associated injection site reaction (ISR) has been reported in patients treated with cisplatin, an irritant drug.We conducted this retrospective study to clarify the incidence and symptoms of fosaprepitant-associated ISR anthracycline.Patients methods: Fifty six receiving 159 injections administering doxorubicin/cyclophosphamide (AC), fluorouracil/epirubicin/cyclophosphamide (FEC), or rituximab/cyclophosphamide/doxorubicin/vincristine/prednisolone (R-)CHOP regimen...
Background. Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance of the lower digestive tract is one mechanisms involved in symptom generation patients with irritable bowel syndrome (IBS). Biobran, arabinoxylan compound derived from rice bran, has been reported to have several biological actions such as anti-inflammatory and modulatory effects. So we investigated therapeutic effects Biobran IBS. Method. Forty diarrhea predominant or mixed type IBS were...
BCL6 is a transcriptional repressor that has important functions in lymphocyte differentiation and lymphomagenesis, but there have been no reports of expression gastric cancers. In the present study, we investigated function Treatment with TPA resulted degradation cyclin D2 upregulation. This phenomenon was inhibited by suppression nuclear translocation HB-EGF-CTF (C-terminal fragment pro-HB-EGF). The leads to interaction export BCL6, after mediated ubiquitin/proteasome pathway. Real-time...
Fourteen patients with hypospadias were treated surgically for either an enlarged prostatic utricle (6) or vagina masculina (8). Six vaginae masculinae removed by extravesical abdominal approach. One was the perineal Three utricles abdominoperineal The transtrigonal approach recently used three and one in four patients. Surgical results these 14 satisfactory. post-operative complication of transient mild bilateral vesicoureteric reflux seen after a removal utricle. Potency not affected any...
Abstract Human gastric epithelium has a unique mucin gene expression pattern, which becomes markedly altered in gastrointestinal disorder. This alteration expression, including the MUC5AC, may be related to development and prognosis of cancers, MUC5AC‐positive cancer been reported poor prognosis. However, molecular mechanism MUC5AC transcriptional regulation not fully elucidated. AT motif‐binding factor 1 (ATBF1) is homeotic regulatory recently identified as tumor suppressor gene, its...
We analyzed renal growth and development of scars in 754 children with primary 169 secondary vesicoureteral reflux. The incidence a small kidney was 15.5 per cent the 24.1 groups. About three-fourths kidneys remained from first examination through followup. Catch-up only exceptional. New or progression previous scarring observed 7.4 30 groups, respectively. Factors that promote formation new are high grade reflux, recurrent urinary tract infections abnormal bladder function results pressure...
The clinical efficacy and outcomes of pazopanib treatment for metastatic extraosseous Ewing sarcoma remain unclear. We herein report a case heavily pre-treated in which achieved significant improvement. A 17-year-old girl was referred to our hospital due sarcoma. initial cytotoxic chemotherapy temporarily effective, however, her disease eventually progressed, she subsequently treated with pazopanib. recurrent tumor showed marked response therapy; the therapeutic effect has lasted more than...
Adalimumab (ADA) is applied to induce remission in patients with Crohn's disease (CD) naïve chimeric anti-tumor necrosis factor-α (anti-TNF-α), infliximab or loss of response scheduled maintenance infliximab. Adsorptive granulocyte and monocyte apheresis (GMA) depletes elevated/activated myeloid lineage leucocytes as sources inflammatory cytokines has been used treat CD. This study was investigate the efficacy intensive GMA combination ADA induction therapy cases CD refractory medications...