A5008967277- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Gastroesophageal reflux and treatments
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Cancer-related gene regulation
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Diet and metabolism studies
- Eosinophilic Esophagitis
- HER2/EGFR in Cancer Research
- Microscopic Colitis
- Congenital gastrointestinal and neural anomalies
- Cancer Cells and Metastasis
- Intestinal and Peritoneal Adhesions
- Cell Adhesion Molecules Research
- Lung Cancer Diagnosis and Treatment
Aichi Medical University
2015-2024
Aichi Medical University Hospital
2022-2023
Kin-ikyo Chuo Hospital
2022
Nagoya City University
2009-2020
Mizuho (Japan)
2012-2020
Background/Aims: Evidence suggests that intestinal microbiota, along with factors such as diet and host genetics, contributes to obesity, metabolic dysfunction diabetes. Therefore, we examined the relationship between gut blood markers, dietary habits fecal short-chain fatty acids (SCFAs) in patients type 2 diabetes mellitus (T2DM). Methods: Dietary habits, samples from 59 T2DM were recruited, association of microbiota markers was analyzed. Results: Total energy intake 1,692 ± 380 kcal/day....
Few studies have investigated the host-microbe metabolic axis in people with type 2 diabetes mellitus (T2DM). This study aimed to determine and compare nutrient intakes markers elucidate relationships among these factors Japanese T2DM patients control individuals. Fifty-nine 59 matched healthy individuals participated this study. We examined differences regarding participants' dietary habits, microbiota, fecal short-chain fatty acids, analyzed between gut microbiota blood subjects. The...
Abstract Background With the goal of discovering non-invasive biomarkers for early diagnosis GC, we conducted a case-control study utilising urine samples from individuals with predominantly GC vs. healthy control (HC). Methods Among 372 patients, age- and sex-matched 282 patients were randomly divided into three groups: 18 in discovery cohort; 176 training cohort 88 validation cohort. Results urinary proteins identified comprehensive quantitative proteomics analysis, levels TFF1 (uTFF1)...
Although the early diagnosis of gastric cancer provides opportunity for curative endoscopic resection, comprehensive screening endoscopy would be invasive and expensive. To date, there is a complete absence clinically useful biomarkers. With goal discovering noninvasive biomarkers cancer, we have conducted case-control study using urine samples from individuals with versus healthy control samples. Of enrolled 106 patients September, 2012 to April, 2013, cohort 70 composed 35 age- sex-matched...
Background Endoscopic submucosal dissection (ESD) is a curative, standard therapy for colorectal neoplasms. Some studies have investigated the risk factors perforation during ESD. However, few assessed delayed bleeding after We studied patients undergoing ESD epithelial neoplasms to identify post-ESD bleeding. Patients and methods 124 consecutive To post-ESD, recurrent was compared with patient-related tumor-related factors. Results Delayed occurred in 10 (8.1%) lesions of tumors, median...
Despite the confirmed anti-cancer effects of T-cell immune checkpoint inhibitors, in colorectal cancer (CRC) they are only effective a small subset patients with microsatellite-unstable tumors. Thus, therapeutics targeting other types CRCs or tumors refractory to inhibitors desired. The binding aberrantly expressed CD47 on tumor cells signal regulatory protein-alpha (SIRPA) macrophages allows evade destruction. Based these observations, drugs macrophage have been developed expectation...
(1) Background: Additional surgical resection after endoscopic (ER) is recommended for patients with submucosal invasive colorectal cancer (pT1 CRC) who have risk factors lymph node metastasis (LNM) (high-risk pT1 CRC). This study aimed to identify LNM and metastatic recurrence determine the low-risk population whom additional surgery can be omitted among high-risk CRCs. (2) Methods: We retrospectively identified 404 CRC underwent ER or surgery, were divided into three groups: (n = 79); 40);...
Background & Aims: In Japan, 7-day triple therapy for Helicobacter pylori including clarithromycin (CAM) was approved in 2000. However, antibiotic resistance subsequently reduced this rate to an unacceptable level (70%). Vonoprazan, orally bioavailable potassium-competitive acid blocker (P-CAB), Japan 2014. This could improve eradication rates by increasing the intragastric pH, thus bacterial susceptibility. study compared efficacy of therapies that included CAM and vonoprazan or proton...
Mesothelin (MSLN) is a glycophosphatidylinositol (GPI)‑linked cell surface protein that highly expressed in several types of malignant tumor, including pleural mesothelioma, ovarian cancer and pancreatic adenocarcinoma. Recently, comprehensive immunohistochemical study using MN‑1 monoclonal antibody identified significant number colorectal tumors which MSLN was expressed. However, the clinicopathological profiles survival patients with MSLN‑positive have not been fully analyzed. In current...
p53 immunohistochemistry is considered an accurate surrogate marker reflecting the underlying TP53 mutation status and has utility in tumor diagnostics. In present study, 269 primary CRCs were immunohistochemically evaluated for expression to assess its diagnostic pathology prognostication. was wild-type 59 cases (23%), overexpressed 143 (55%), completely lost 50 (19%), cytoplasmic 10 (4%). immunoreactivity associated with size (p = 0.0056), mucus production 0.0015), mismatch repair (MMR)...
Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is an important target in the treatment of inflammatory bowel disease (IBD). Recently, IBD with antibody to alpha4beta7-integrin, a ligand for MAdCAM-1, has been intense focus research. Our aim was clarify mechanism by which MAdCAM-1 regulated via angiotensin II type receptor (AT1R), and verify if AT1R might be novel treatment. The role expression SVEC (a murine high endothelial venule cell) MJC-1 mouse colonic examined following...
Background. Recently, it was revealed that low grade mucosal inflammation and/or immune imbalance of the lower digestive tract is one mechanisms involved in symptom generation patients with irritable bowel syndrome (IBS). Biobran, arabinoxylan compound derived from rice bran, has been reported to have several biological actions such as anti-inflammatory and modulatory effects. So we investigated therapeutic effects Biobran IBS. Method. Forty diarrhea predominant or mixed type IBS were...
Evidence for the tumor-supporting capacities of cancer-associated fibroblasts (CAFs) has rapidly been accumulating. To uncover clinicopathological importance periostin (POSTN) expression in colorectal cancer (CRC), present study immunohistochemically examined its status. Furthermore, to reveal mechanisms involved, molecular experiments were performed. In CRC tissues, 44% cases (119/269) exhibited POSTN CAFs. contrast, cells expressed at almost undetectable levels. Survival analyses...
SATB2 has been reported to be highly specific for lower gastrointestinal tract tumors. On the basis of its ileum-colon conversion effects, which involve activation colonic genes in cooperation with CDX2 and HNF4A, we hypothesized that might define characteristics colorectal cancers (CRCs). In present study, clinicopathologic immunohistochemical 269 CRCs were analyzed according expression. SATB2- and/or CDX2- phenotypes showed associations poorly differentiated histotypes ( P <0.00001), mucus...
In Japan, the prevalence of constipation-predominant irritable bowel syndrome (IBS-C) and functional constipation (FC) diagnosed by Rome III criteria is unclear, as are demographic profile, quality life (QOL), habits persons with IBS-C or FC. We performed an internet survey constipation. After extracting 3000 fitting composition general Japanese population, we investigated factors, lifestyle, defecation, laxatives. FC were criteria. Respondents also completed IBS severity index (IBS-SI-J),...
Colorectal cancer (CRC) is one of the most frequent gastrointestinal cancers worldwide, with high morbidity and mortality rates. Despite numerous attempts to identify prognostic markers for CRC patients, significance association cellular proliferation survival controversial. Here we used immunohistochemistry detect four expressed in primary tissue specimens (n = 269) assess their potential serve as factors. cells variably phospho‐histone H3 (PHH3) (range, 0–76 per high‐powered field (HPF);...