A5033022573- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Immunotherapy and Immune Responses
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Helicobacter pylori-related gastroenterology studies
- Cancer Treatment and Pharmacology
- Bladder and Urothelial Cancer Treatments
- Eosinophilic Esophagitis
- Breast Cancer Treatment Studies
Nagoya City University
2017-2024
Mizuho (Japan)
2019-2024
Toho University
2023
Japanese Red Cross Nagoya Daini Hospital
2013-2017
Gifu Prefectural Tajimi Hospital
2015-2016
Institute for Atherosclerosis Research
2015
Kitakyushu Municipal Medical Center
2006
Kumamoto City Hospital
2006
Nihon University
2001-2002
British Society of Periodontology
2001
Background: There is an increasing body of evidence implicating reactive oxygen species in the pathogenesis periodontal tissue destruction. 8‐hydroxy‐deoxyguanosine (8‐OHdG) one most commonly used markers to evaluate oxidative damage a number disorders including chronic inflammatory diseases. The aim present study was 8‐OHdG levels whole saliva patients with periodontitis and assess changes after initial treatment. Methods: Saliva samples were collected from 78 untreated 17 healthy control...
Abstract Background With the goal of discovering non-invasive biomarkers for early diagnosis GC, we conducted a case-control study utilising urine samples from individuals with predominantly GC vs. healthy control (HC). Methods Among 372 patients, age- and sex-matched 282 patients were randomly divided into three groups: 18 in discovery cohort; 176 training cohort 88 validation cohort. Results urinary proteins identified comprehensive quantitative proteomics analysis, levels TFF1 (uTFF1)...
Abstract Background Gastric cancer (GC) patients frequently develop peritoneal metastasis; however, the underlying mechanism remains unknown. We hypothesised that omental adipocytes (OmAd) trigger GC cells towards malignant activity to induce metastasis. Methods analysed interactions among human cells, endothelial and OmAd using a 3D co-culture system. also employed multipronged animal study, including subcutaneous orthotopic tumours, humanised adipose tissue models. Urinary levels of CXCL2...
Since noninvasive biomarkers as an alternative to invasive colonoscopy detect colorectal cancer (CRC) are desired, we conducted this study determine the urinary biomarker consisting of microRNAs (miRNAs). In total, 415 age- and sex-matched participants, including 206 patients with CRC 209 healthy controls (HCs), were randomly divided into three groups: (1) discovery cohort (CRC, n = 3; HC, 6); (2) training (140 pairs); (3) validation (63 pairs). Among 11 miRNAs aberrant expressions between...
(1) Background: Additional surgical resection after endoscopic (ER) is recommended for patients with submucosal invasive colorectal cancer (pT1 CRC) who have risk factors lymph node metastasis (LNM) (high-risk pT1 CRC). This study aimed to identify LNM and metastatic recurrence determine the low-risk population whom additional surgery can be omitted among high-risk CRCs. (2) Methods: We retrospectively identified 404 CRC underwent ER or surgery, were divided into three groups: (n = 79); 40);...
Background and Aim Endoscopic reintervention for stent occlusions following bilateral self‐expandable metallic (SEMS) placement malignant hilar biliary obstruction (MHBO) is challenging, time to recurrent (RBO) of the revisionary remains unclear. We aimed clarify a suitable method SEMS MHBO. Methods Between 2002 2014, 52 consecutive patients with MHBO who underwent endoscopic occlusion after were enrolled at two university hospitals one tertiary care referral center. retrospectively...
Abstract Esophageal cancer (EC) including esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) generally exhibits poor prognosis; hence, a noninvasive biomarker enabling early detection is necessary. Age- sex-matched 150 healthy controls (HCs) 43 patients with ESCC were randomly divided into two groups: 9 individuals in the discovery cohort for microarray analysis 184 training/test cross-validation qRT-PCR analysis. Using 152 urine samples (144 HCs 8 EACs), we validated urinary...
Bleeding events related to endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) are rare. However, for patients treated with antithrombotic agents, the bleeding risk of EUS-FNA is uncertain. Hence, aim this study was assess event rate associated in receiving treatment.A retrospective conducted 742 consecutive who underwent solid lesions between 2008 and 2015. We compared rates among were not administered those whose agent use discontinued, continued treatment aspirin or cilostazol,...
Hiroyasu Iwasaki, Takashi Mizushima, Yuta Suzuki, Shigeki Fukusada, Kenta Kachi, Takanori Ozeki, Kaiki Anbe, Hironobu Tsukamoto, Fumihiro Okumura, Joh, and Hitoshi Sano. Gut Liver 2017;11:47-54. https://doi.org/10.5009/gnl16172
Since a fecal occult blood test for colorectal cancer (CRC) does not offer sufficient diagnostic power CRC, novel non-invasive biomarkers are hopeful CRC screening. We conducted the current study to discover urinary diagnosing CRC. Among urine samples from 258 patients (CRC, n = 148; healthy controls, 110), cohort of 176 composed 88 with GC and controls was selected after age- sex-matching using propensity score. This then randomly divided into 2 groups: 53 pairs (106 patients) in training...
Active pharmaceutical ingredients (APIs) often exhibit physicochemical problems that one can remedy by various methods (e.g., salt formation, grinding, ordered mixtures, and cocrystal or amorphous formation). Crystallizing salts cocrystals from solutions of an API a coformer is widely used today. In recent years, green chemistry sustainable development goals have been active area research, production method required for reducing the use organic solvents implementing low environmental load....
<b>Background and study aims: </b>Acute colorectal obstruction (ACO) often accompanies cancer (CRC) requires urgent treatment, but achieving elective laparoscopy-assisted colectomy (LAC) is difficult in this setting. The aim of the current was to assess clinical outcomes a transanal tube (Dennis [DCT]) for CRC with ACO, focusing particular on impact DCT subsequent LAC. <b>Patients methods: </b>Among 1142 patients who underwent surgery between January 2007 December 2011, 92 ACO were...
A man in his thirties visited our hospital for an evaluation of a 12×10-mm pancreatic solid tumor that was accidentally detected on computed tomography performed follow-up familial adenomatous polyposis (FAP). We diagnosed the patient with pseudopapillary neoplasm (SPN) based endoscopic ultrasound-guided fine-needle aspiration, and he underwent pancreaticoduodenectomy. Small SPN tumors appear as tumors, without typical features SPN, making definitive diagnosis more difficult. The genetic...
A barbed puncture needle with a side hole was recently developed to improve sample quality and quantity in endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). In this study, we retrospectively assessed the usefulness of needle.Factors affecting diagnostic yield, safety, accuracy were investigated 76 patients who consecutively underwent EUS-FNA for neoplastic lesions at our hospital between January December 2013.The procedure successful all cases; rates collection determination...
Previous studies have described the effect of irradiation by a carbon dioxide (CO2) laser at high energy density on oral bacteria, and various side-effects also been observed. However, no published examined CO2 low bacteria. The purpose this study was to investigate effects super pulsed periodontopathic bacteria lipopolysaccharide (LPS).Bacterial suspensions two species received densities 0-12.5 J/cm2. were then spread over agar plates incubated anaerobically. bactericidal evaluated based...
We herein describe a rare case of gastric cancer that was treated with chemotherapy during pregnancy. A woman in her thirty's at 23 weeks gestation admitted to the hospital epigastralgia and left cervical lymph node swelling. She had been previously diagnosed metastatic adenocarcinoma another hospital. Findings from CT scan esophagogastroduodenoscopy revealed progressive cancer, pathology indicated poorly differentiated adenocarcinoma. Chemotherapy administered 24 gestation, without...
The current imaging modalities are not sufficient to identify inoperable tumor factors, including distant metastasis and local invasion. Hence, we conducted this study using urine samples discover non-invasive biomarkers for the incurability of gastric cancer (GC). Urine from 111 GC patients were analyzed in study. cohort was categorized according disease stage operability. In discovery phase, protease protein array analysis identified 3 potential candidate proteins that elevated advanced...