A5028556837- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Breast Cancer Treatment Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Surgical Treatments
- Liver physiology and pathology
- Abdominal Trauma and Injuries
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Breast Lesions and Carcinomas
- Biliary and Gastrointestinal Fistulas
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Abdominal Surgery and Complications
- Intraperitoneal and Appendiceal Malignancies
- Pancreatitis Pathology and Treatment
Toyota Kosei Hospital
2015-2024
Sendai Kousei Hospital
2015-2016
Konan Kosei Hospital
2015
Toyota Motor Corporation (Switzerland)
2012-2013
Red Cross Hospital
2008-2013
Japanese Red Cross Nagoya Daini Hospital
2008-2013
Nagoya University
1997-2003
Shizuoka Saiseikai General Hospital
2001-2003
Nagoya City University
2001
Japanese Red Cross Nagoya Daiichi Hospital
1995-1996
Abstract Background Few larger studies have estimated the incidence of incisional hernia (IH) after abdominal surgery. Methods Patients who had surgery between November 2009 and February 2011 were included in study. The rate risk factors for IH monitored at least 180 days. Results A total 4305 consecutive patients registered. Of these, 378 excluded because failure to complete follow-up 3927 analysed. was diagnosed 318 patients. rates 5·2 per cent 12 months 10·3 24 months. In multivariable...
<b>Background and study aims: </b>Acute colorectal obstruction (ACO) often accompanies cancer (CRC) requires urgent treatment, but achieving elective laparoscopy-assisted colectomy (LAC) is difficult in this setting. The aim of the current was to assess clinical outcomes a transanal tube (Dennis [DCT]) for CRC with ACO, focusing particular on impact DCT subsequent LAC. <b>Patients methods: </b>Among 1142 patients who underwent surgery between January 2007 December 2011, 92 ACO were...
Hyperbaric oxygen (HBO) therapy is a controversial treatment for adhesive postoperative small bowel obstruction, with only few studies reported. The aim of this study was to assess the clinical value HBO in obstruction.Between April 2006 and March 2012, all patients obstruction were treated using either decompression or HBO. Patients undergoing once day at pressure 2·0 atmospheres absolute received 100 per cent oxygen. showing no radiological improvement converted by means long tube. Medical...
Mucins are implicated in survival various cancers, but there have been no report addressed on appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the implications expression mucins carcinoma.Expression profiles MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 MUC17 cancer tissue were examined by immunohistochemistry 108 cases surgically resected carcinoma.The following relationships...
Mucins have been associated with survival in various cancer patients, but there no studies of mucins small bowel carcinoma (SBC). In this study, we investigated the relationships between mucin expression and clinicopathologic factors 60 SBC cases, which profiles MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6 MUC16 normal tissues were examined by immunohistochemistry. MUC5AC was increased lesions compared to epithelium, these related factors, as follows: MUC1 [tumor location (p = 0.019), depth 0.017)...
Telomerase is a unique reverse transcriptase involved in the maintenance of telomeric DNA, which generally undetectable normal human somatic cells. However, it has been found organs adult rodents including liver. In order to elucidate relevant control mechanisms operating cells, we examined telomerase activity primary cultured rat hepatocytes. During culture under serum-free conditions, hepatocytes rapidly lose ability organ-specific expression serum albumin, apolipoprotein A-I, and...
We measured the concentration of hepatocyte growth factor (HGF) in bile obtained from patients after hepatectomy. The HGF concentrations samples were quantified using an enzyme-linked immunosorbent assay (ELISA). By immunoblotting, a monoclonal antibody raised against α-subunit, HGF, which was purified on Heparin-Sepharose column, showed band same size as recombinant α-subunit (69 kd). Bile 24 with biliary tract disease before and hepatectomy by means drainage. Before surgery, minimal (0.8 ±...
Carcinoid tumors located in the minor duodenal papilla are extremely rare, with only a few cases reported literature. Herein, we report case of 71-year-old man 12-mm carcinoid tumor at lymph node metastases. Multidetector-row computed tomography contrast enhancement revealed well-enhanced duodenum. Upper gastrointestinal endoscopy showed submucosal Biopsy specimens tumor, and subtotal stomach-preserving pancreatoduodenectomy was performed. have high prevalence nodal disease, even for <2 cm...
高度胆嚢炎症例に対する腹腔鏡下胆嚢亜全摘術(以下, LSC)の安全性を評価する. 2004年1月～2007年8月に当科で施行した腹腔鏡下胆嚢摘出術750例中, Calot三角の剥離を危険と判断してLSCを施行した25例. 底部側より胆嚢を肝床から遊離させ, endoscopic linear stapler(以下, ELS)または縫合・結紮により頸部を閉鎖・切離した. 必要に応じ頸部の壁を切開して胆嚢内腔を確認し, 経胆嚢管的に術中胆道造影を試みた. 残存した粘膜を焼却した. 開腹移行例や副損傷例を認めず. 頸部閉鎖法はELS19例, 縫合・結紮6例であった. 手術時間は平均143±43分, 出血量は20±32g, ドレーン留置期間は2.7±1.8日, 術後在院日数は5.2±2.2日であった. 遅発性胆汁漏と総胆管結石の発生を各1例に認めた. 1例で術前非疑診胆嚢癌が発見された. LSCは重篤な副損傷を避けうるという観点からは安全な手術であるが, 遺残胆嚢に関連する合併症に留意する必要がある.
症例は60歳の男性で, 併存症に糖尿病. 発熱, 心窩部痛を主訴に当院を受診. 急性胆嚢炎の診断で経皮経肝胆嚢ドレナージ(perctaneous transhepatic gallbladder drainage; 以下, PTGBD)を施行した. CT上胆嚢は門脈臍部の左側に存在するように見え, 左側胆嚢を疑った.PTGBD造影と内視鏡的逆行性胆管造影検査で, 右肝管が胆嚢管に合流する胆管走向異常を認めた. ドレナージで炎症が消退したのち, 腹腔鏡下胆嚢摘出術を施行した. 胆嚢の炎症は高度で, 胆嚢底部は肝円索の左側に位置していた. 門脈臍部を損傷しないよう慎重に胆嚢床の切離をすすめ, また右肝管の損傷を避けるためCalot三角部は剥離せず, 胆嚢頸部をステイプラーで閉鎖した. 困難症例であったが, 腹腔鏡手術を完遂し, 第6病日に退院した. 右肝管が胆嚢管に合流する胆管走向異常と左側胆嚢が併存する極めてまれな症例であった.
Interleukin (IL) 6 is one of the important components early signalling pathways leading to liver regeneration, and has been detected in bile after transplantation. IL-6 concentrations were studied an attempt predict function major hepatectomy for biliary tract carcinoma.This study involved 24 patients without cirrhosis who underwent carcinoma. The was sampled regularly through external drainage tubes. serum measured using enzyme-linked immunosorbent assay.Bile increased 37-fold (from...
症例は61歳の女性で，水溶性下痢を主訴に2008年11月当院を受診し，腹部CTで下行結腸を腹側から圧排する65mm×37mmの腹腔内膿瘍を認めた．大腸内視鏡検査では下行結腸に瘻孔開口部を認め，注腸検査では同部位から膿瘍腔を介して造影剤の小腸への流出を認めた．空腸下行結腸瘻，腹腔内膿瘍の診断で開腹手術を施行した．空腸・下行結腸部分切除を施行し，横行結腸で双孔式の人工肛門を造設した．病理組織学的検査所見では，穿孔部周辺の空腸および下行結腸壁全層に中型リンパ球のびまん性増殖を認めた．免疫染色ではCD3 （+），CD7（+），CD8（-），CD56（+）を示し，腸管型T細胞リンパ腫type IIと診断した．術後CHOP療法を2回施行したが，消化管穿孔性腹膜炎を起こしたことにより術後4カ月で死亡した．
症例は73歳の男性で，ふらつきの増悪を主訴として当院を受診した．血液生化学検査で貧血を認め，CEAとCA19-9が軽度上昇していた．上部消化管内視鏡検査では胃小弯に隣接した口側の3型腫瘍と肛側の2型腫瘍を認めた．両病変から生検を行い，ともに中分化型腺癌と診断された．腹部CTでは2箇所に分かれた胃壁肥厚と小弯側リンパ節の腫大を認めた．以上より胃の進行衝突癌と術前診断し，胃全摘術を施行した．病理組織学的に二つの腫瘍はわずかな正常粘膜を介在して粘膜下層以深で隣接していた．口側病変は著明にリンパ球が浸潤したEpstein-Barr virus関連胃癌と診断され，肛側病変は中分化型腺癌であった．Epstein-Barr virus encoded RNA in situ hybridizationによって「真の衝突癌」であることを証明することができた．
症例は91歳，女性．平成19年1月，下腹部痛を主訴に当院救急外来を受診した．腹部CT検査にて肝表面に限局した腹水とfree air，小腸浮腫と小腸内高吸収域を認めた．既往に卵巣癌放射線治療，PTP誤飲による開腹手術があった．放射線性腸炎や異物誤飲による穿孔性腹膜炎が強く疑われ緊急手術の適応と考えた．しかし，家族の同意が得られず局所麻酔下に経皮的ドレナージを行うに止めた．全身状態の改善した後，腹部MDCT検査によりPTPによる小腸穿孔と診断し待期的に手術を施行した．術後経過は良好で，独歩で退院した．PTP再誤飲による小腸再穿孔という極めて稀な症例を経験した．
急性胆嚢炎の腹腔鏡手術（以下LC）における経皮経肝胆嚢ドレナージ（以下PTGBD），特に早期PTGBDの意義について検討した．PTGBDを先行した待機的LCは119例であった．治療成績は，開腹移行4.2％，平均手術時間111分，発症からPTGBD 4.4日，PTGBDから手術32.8日であった．手術時間に影響する因子は発症からPTGBDまでの期間で，4日以内，特に2日以内では有意に時間が短縮した．また，術前の難易度評価5点以下，CRP値が短期に改善した例では有意に時間が短縮した．PTGBDから手術までの期間，術前の白血球数，CRP値には有意差を認めなかった．中等症以上の急性胆嚢炎例に対して安全に待機的LCを行うためには，PTGBDが有用であり，特に発症4日以内にPTGBDを行うことが重要である．また，早期PTGBDが行われた場合には30日程度の待機期間をおいても安全にLCが施行できる．