A5082039051- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Soil and Unsaturated Flow
- Crystallography and molecular interactions
- Landfill Environmental Impact Studies
- Metal complexes synthesis and properties
- Polyoxometalates: Synthesis and Applications
- Radioactive element chemistry and processing
- Fire effects on ecosystems
- Geotechnical Engineering and Soil Stabilization
- Metal-Organic Frameworks: Synthesis and Applications
- Metalloenzymes and iron-sulfur proteins
- Graphene research and applications
- Organometallic Compounds Synthesis and Characterization
- Chemical Synthesis and Characterization
- Crystal structures of chemical compounds
- Porphyrin and Phthalocyanine Chemistry
- Catalytic Cross-Coupling Reactions
- Grouting, Rheology, and Soil Mechanics
- Graphite, nuclear technology, radiation studies
- Vanadium and Halogenation Chemistry
- Photochemistry and Electron Transfer Studies
- Geochemistry and Elemental Analysis
- Methane Hydrates and Related Phenomena
- Drug Transport and Resistance Mechanisms
Kyushu University
2017-2022
Kanazawa University
2016-2020
Shibaura Institute of Technology
2017-2018
Kwansei Gakuin University
2016
Osaka City University
2013-2015
Okayama University of Science
2011-2014
Keio University
2011-2012
Osaka University
2007-2010
Kobe Women's Junior College
1989
Cisplatin (CDDP) is the most frequently used chemotherapeutic agent for various types of advanced cancer, including gastric cancer. However, almost all cancer cells acquire resistance against CDDP, and this phenomenon adversely affects prognosis. Thus, new agents that can overcome CDDP-resistant will improve survival patients.We synthesized glycoconjugated platinum (II) palladium complexes, [PtCl2 (L)] [PdCl2 (L)]. cell lines were established by continuous exposure to gene expression in was...
An enantioselective formal total synthesis of (+)-manzacidin C is described. A key feature the construction two chiral centers via asymmetric 1,3-dipolar cycloaddition an azomethine imine to methallyl alcohol by use (S,S)-DIPT as a auxiliary.
In order to understand the adsorption preferences of extracellular polymeric substances (EPS) components derived from fungus Saccharomyces cerevisiae on sparingly soluble CeO2 nanoparticles (CeNPs), experiments EPS including organic matter with low molecular weight have been performed at pH 6.0 room temperature (25 ± 1 °C). The subsequent effects coating dispersibility CeNPs was systematically measured as a function time and ionic strength ranging 1000 mmol L−1. Among other components,...
CUB domain‐containing protein‐1 ( CDCP 1) is a trans‐membrane protein predominantly expressed in various cancer cells and involved tumor progression. 1 phosphorylated at tyrosine residues the intracellular domain by Src family kinases recruits PKC δ to plasma membrane through phosphorylation‐dependent association with C2 of δ, which turn induces survival signal an anchorage‐independent condition. In this study, we used our cell‐free screening system identify small compound, glycoconjugated...
Background An accumulating body of evidence suggests that Dtnbp1 (Dysbindin) is a key susceptibility gene for schizophrenia. Using the yeast-two-hybrid screening system, we examined candidate proteins interacting with Dysbindin and revealed one these candidates to be transcription factor NF-YB. Methods We employed an immunoprecipitation (IP) assay demonstrate Dysbindin-NF-YB interaction. DNA chips were used screen altered expression genes in cells which or NF-YB was down regulated, while...
Four kinds of cobalt-polyoxomolybdenum clusters were synthesized by a combination polyoxomolybdates and Co-tacn (tacn = 1,4,7-triazacyclononane) complex. The heterometallic polynuclear obtained the reaction Na2MoO4 [Co(tacn)(H2O)3](CF3SO3)3·H2O in water. peripherals are capped thermodynamically stable [Co(tacn)]3+ protecting groups to prevent further hydrolysis condensation reactions. Intra-molecular hydrogen bonds between N-H on tacn oxygen atoms molybdate core contribute stability...
A new bis(N2O2) ligand, L4−, in which two tripodal diamine-bis(phenolate) moieties are bridged by a xanthene backbone, was prepared. The reaction of H4L with 2 equiv. [Ti(OiPr)4] produced C2 and Cs symmetrical isomers the dititanium(IV,IV) complex [Ti2(L)(OiPr)4]. isolated isomer slowly converted to via Ti–N bond cleavage form 3 : mixture equilibrium. similar dimanganese(III,III) [Mn2(L)(OMe)2(MeOH)2] synthesized from 1 manganese(II) perchlorate presence triethylamine. An X-ray analysis...
To understand the competing effects of components in extracellular substances (ES), polymeric (PS) and low-molecular-weight small (SS) <1 kDa derived from microorganisms, on colloidal stability cerium dioxide nanoparticles (CeNPs), we investigated their adsorption to sparingly soluble CeNPs at room temperature pH 6.0. The ES was extracted fungus S. cerevisiae. polypeptides phosphates all preferentially adsorbed onto CeNPs. zeta potentials + CeNPs, PS SS overlapped plot itself, indicating...
An isolation of a vanadium(V) oxide cluster mimicking V2O5 layered structure was achieved formulated as [{Co(tacn)}4V4O12(OH)4]4+ (1) (tacn = 1,4,7-triazacyclononane). From the 51V NMR spectra reaction mixtures, we optimized condition in terms molar ratio VO43- and [Co(tacn)(H2O)3]3+ well pH value. Cluster 1 is stable wide range values from 1.5 to 8.0, presence multiple hydrogen bondings unique feature. In X-ray analysis 1, V⋯ V distances are classified into two groups relatively shorter...
The reaction of sulfur-bridged incomplete cubane-type molybdenum complex [Mo3(µ-S)3(µ3-S)(dtp)3(CH3CN)(µ-OAc)] (1) (dtp: diethyl dithiophosphate) with dimethyl acetylenedicarboxylate (H3COOCC≡CCOOCH3, DMAD) in several kinds solvents gave solvent-dependent adducts. use acetone, acetaldehyde, acetylacetone, ethyl acetoacetate, and acetophenone as the following adducts, respectively: [Mo3{µ-SCH(COCH3)}(µ3-S){µ3-SC(CO2CH3)=C(CO2CH3)S}(dtp)3(µ-OAc)] (2),...
A trimanganese core containing polyoxovanadate {Et4N}5[Mn3(OAc)(H2O)V10O30] (I; OAc = acetate) was synthesized by the reaction of {Et4N}[VO3] with Mn(OAc)2 (0.3 equiv.) in acetonitrile. The possesses a bridging acetate ligand. To demonstrate ligand-exchange properties I, its benzoic acid (1 conducted and {Et4N}5[Mn3(OBz)(H2O)V10O30] (II; OBz benzoate) formed quantitatively. By using dicarboxylate, inorganic–organic–inorganic hybrid {Et4N}10[{Mn3(H2O)V10O30}2{OOC(CH2)nCOO}] [n 3 (III) n 4...
Three novel fluorescent fluoro–silicon(IV) complexes of the type [SiF3(L)] (HL = Schiff base) were synthesized, and their properties investigated: one [SiF3(L1)] (1; ΦF 0.96; HL1 2-hydroxy-1-naphthylmethylene-8-aminoquinoline) shows an extremely high fluorescence quantum yield, other [SiF3(L2)] (2; 0.11; HL2 3,5-dichlorosalicylidene-8-aminoquinoline) [SiF3(L3)] (3; 0.01; HL3 3,5-dibromosalicylidene-8-aminoquinoline) show moderate low yields in DMSO, respectively. The Stokes shift 1 (2690...
A series of potentially tridentate Schiff base ligands, {HOPhC=N-(CH2)3-XMe: X = S (HLSMe), Se (HLSeMe)}, was prepared by condensation reactions salicylaldehyde and the corresponding functionali...
水酸化チタン (IV) Tio2・nH20 または酸化チタン Tio2 (ルチルおよびアナタース型) とリン酸とのオートクレープ中での反応により, 結晶性ビス (リン酸-水素) チタン 二水和物 Ti(HPO4)2・2H2O(γ-Tip) の製法を確立した。水酸化チタン および酸化チタン 系のいずれの系においても, γ-Tip の生成には混合罰合 (P205/Tio2), 加熱温度, 加熱時間および水蒸気圧が大きく影響した。γ-TiPの合成最適条件としては, 系においては, P205/TiO2=1.2～1.5, 加熱温度 225～250℃, 加熱時間3時間以上, 水蒸気圧 15atm 以上, また酸化チタン 200～210℃, 8atm 以上がもっとも有効であった。本方法で合成した γ-TiP は水溶液中のアンモニアおよびアンモニアガスを効果的に吸着した。
Three ACNU-resistant clones (R1, R3, and R12) were isolated from 9L rat glioma cells under selection pressure of ACNU in vitro. The authors have investigated the mechanisms resistance characteristics these at cellular level by studying cross-resistance patterns to chemical physical agents. Although resistant sublines showed complete methyl-chloroethylnitrosourea (MCNU), no was observed for other alkylating agents, while each partial structurally dissimilar toxic agents (vinblastine,...
A novel complex with the terminal acetonitrile and bridging trifluoroacetate (tfa) ligands of [Mo3S4(dtp)3(μ-tfa)(NCCH3)] (dtp: diethyl dithiophospate) (1-tfa) was prepared from substitution re...