A5050525630- Bone Metabolism and Diseases
- Sarcoma Diagnosis and Treatment
- Heat shock proteins research
- Orthopaedic implants and arthroplasty
- Bone Tumor Diagnosis and Treatments
- NF-κB Signaling Pathways
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Shoulder Injury and Treatment
- Energy Efficient Wireless Sensor Networks
- Orthopedic Surgery and Rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Metabolism, Diabetes, and Cancer
- Elbow and Forearm Trauma Treatment
- Orthopedic Infections and Treatments
- Platelet Disorders and Treatments
- Sirtuins and Resveratrol in Medicine
- Spinal Fractures and Fixation Techniques
- Indoor and Outdoor Localization Technologies
- Spine and Intervertebral Disc Pathology
- Bone fractures and treatments
- Blood properties and coagulation
- Cell Adhesion Molecules Research
- Shoulder and Clavicle Injuries
Nagoya Institute of Technology
2014-2024
Otsuka (Japan)
2024
Nagoya City University
2014-2023
Mizuho (Japan)
2005-2022
Tokai Gakuen University
2019-2021
Nagoya University
2012-2017
Tosei General Hospital
2016
Advanced Institute of Industrial Technology
2016
University of California, Irvine
2013
National Hospital Organization Saitama Hospital
2013
Neural crest cells (NCCs) are an embryonic migratory cell population with the ability to differentiate into a wide variety of types that contribute craniofacial skeleton, cornea, peripheral nervous system, and skin pigmentation. This suggests promising role NCCs as source for cell-based therapy. Although several methods have been used induce human (hNCCs) from pluripotent stem (hPSCs), such (ESCs) induced (iPSCs), further modifications required improve robustness, efficacy, simplicity these...
Muscle contusions are a common type of muscle injury and frequently encountered in athletes military personnel. Although these injuries capable healing most instances, incomplete functional recovery often occurs because the development fibrosis muscle. We hypothesized that combination platelet-rich plasma (PRP) injection oral administration losartan (an antifibrotic agent) could enhance by stimulating regeneration angiogenesis preventing contusion-injured skeletal muscle.Contusion were...
Abnormal activation of endochondral bone formation in soft tissues causes significant medical diseases associated with disability and pain. Hyperactive mutations the morphogenetic protein (BMP) type 1 receptor ACVR1 lead to fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterized by progressive ossification tissues. However, specific cellular mechanisms are unclear. In addition, difficulty obtaining tissue samples from FOP patients limitations mouse models hamper...
Posterior and posteroinferior capsules in the shoulder joints of throwing athletes have been reported to be thicker than nonthrowing shoulders, this has a relationship glenohumeral internal rotation deficit (GIRD). However, stiffness these thickened not reported. Shear-wave ultrasound elastography is new technology that can measure tissue elasticity quantitatively.The posterior are stiffer as well shoulders baseball players their shoulders. The thickness inversely correlated with...
Although muscle injuries tend to heal uneventfully in most cases, incomplete functional recovery commonly occurs as a result of scar tissue formation at the site injury, even after treatment with muscle-derived stem cells (MDSCs).The transplantation MDSCs presence transforming growth factor β1 (TGF-β1) antagonist (losartan) would decreased and enhance regeneration contusion mouse model.Controlled laboratory study.An animal model was developed using tibialis anterior 48 healthy mice 8 10...
Successful in vitro disease-recapitulation using patient-specific induced pluripotent stem cells (iPSCs) requires two fundamental technical issues: appropriate control and robust differentiation protocols. To investigate fibrodysplasia ossificans progressiva (FOP), a rare genetic disease leading to extraskeletal bone formation through endochondral ossification, gene-corrected (rescued) iPSC clones (resFOP-iPSC) were generated from patient-derived (FOP-iPSC) as genetically matched controls,...
The effect of mild hyperthermia on a cultured rat malignant fibrous histiocytoma (MFH) cell line, MFH-2NR, was investigated. MFH cells in log-phase (growing phase) were heated at 41°–44°C for 1 hr. Hyperthermic treatment 41°C did not substantially affect proliferation and 44°C caused necrosis. After hyperthermic 42° or 43°C, arrested morphological changes characteristic apoptosis, shrinkage accompanying apoptotic bodies chromatin condensation, became apparent. Hyperthermia-induced apoptosis...
Autologous nerve graft is the most commonly applied treatment for patients with peripheral defect, while application limited because of tissue availability and unfavorable donor site morbidity. To overcome this problem, regeneration using a conduit has been studied. Especially, biodegradable materials considered promising. In study, potential collagen studied special reference to regenerating process nerve. Twelve adult female Beagle dogs weighting 10-12 kg were used. The peroneal was cut...
Although aneurysmal bone cysts (ABCs) are benign tumours, they have the potential to be locally aggressive. Various treatment approaches, such as en bloc resection, open curettage, radiotherapy, sclerotherapy, and embolization been proposed, but most appropriate should selected after considering risk of tumour recurrence complications. Endoscopic curettage (ESC) may a less invasive alternative for ABC treatment. We aimed describe use ESC ABCs report our clinical outcomes, including incidence...
Endoscopic curettage is considered applicable for the treatment of simple bone cysts with expectation that it might be less invasive than open curettage. In this study, we investigated efficacy endoscopic cysts. The goal was to investigate incidence cyst recurrence and healing after Moreover, complications functionality at final follow-up were evaluated.From 2003 2014, 37 patients underwent Twenty-four male 13 female, a mean age 14.7 years. performed support an arthroscope via 7-8 mm holes...
Overall survival rate for 143 digits with complete amputation of the distal phalanx was 78%. Replanted that underwent venous anastomosis showed a very high 93%. Loss interphalangeal joint function in subzone IV significantly inferior to subzones II and III. Protective sensation achieved 96% replanted digits. Sensory recovery absence nerve repair worse avulsion injury than crush injury. Nail deformity tended be increased III or crush-type Successful appears offer best way promote If is...
Residual subluxation of the hip is a major problem in pediatric orthopaedics. Corrective surgery by Salter innominate osteotomy performed for residual before school age. Common indications corrective are determined based on clinical condition, x-ray images, and arthrographic images. However, surgical vary among institutions. Thus, further information that can predict acetabular growth with certainty needed precise decision- making. This study focused signal intensity changes magnetic...
We investigated the relationship between HSP27 phosphorylation and collagen-stimulated activation of platelets in patients with diabetes mellitus (DM). Platelet-rich plasma was prepared from blood type 2 DM patients. The platelet aggregation analyzed size aggregates by an aggregometer using a laser scattering method. protein Western blotting. Phosphorylated-HSP27 PDGF-AB released were measured ELISA. phosphorylated-HSP27 levels at Ser-78 Ser-82 induced collagen directly proportional to...
Nine patients with enchondromas in the hand were treated by endoscopic curettage of tumour without bone grafting. The procedure was performed on an out-patient basis using axillary block anaesthesia. New formation and remodelling lesions observed all patients. There no postoperative fractures, infections, recurrences or other complications. Functional recovery rapid. We conclude that grafting is effective treatment enchondroma hand.
Abstract Objective . To purify a protein inhibitor from rheumatoid arthritis (RA) synovial fluids which suppresses the apparent incorporation of 3 H‐thymidine into fibroblasts and cells, to define its biochemical features that have clinical relevance pathogenesis RA. Methods Several standard chromatographic techniques were employed for purification protein. Immunochemical methods with monoclonal antibody used quantify visualize in sera, fluids, tissues RA patients. Results The chemical...
Identification of the SYT-SSX fusion transcript can be a useful diagnostic aid for synovial sarcoma. However, there is no report on detection specific in archival cytologic specimens. We performed rapid reverse transcription-polymerase chain reaction assay to detect using such specimens as RNA sources and compared its usefulness with formalin-fixed paraffin-embedded histologic Eleven 12 stored 0.1 20 years were selected from 9 patients. The was identified 10 (91%) 11 (75%) cases. One...
Serum amyloid A (SAA) was markedly increased in the plasma and liver upon acute inflammation induced by intraperitoneal injection of lipopolysaccharide (LPS) mice, SAA exclusively associated with HDL. In contrast, no HDL present only a small amount found VLDL/LDL fraction (d < 1.063 g/ml) after induction ABCA1-knockout (KO) although liver. Primary hepatocytes isolated from LPS-treated wild-type (WT) ABCA1-KO mice both secreted into medium. WT HDL, whereas recovered that >1.21 g/ml. The...