A5101616558- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Structural Anomalies and Repair
- Infectious Aortic and Vascular Conditions
- Tissue Engineering and Regenerative Medicine
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Bone Tissue Engineering Materials
- Congenital Heart Disease Studies
- Mesenchymal stem cell research
- Cardiac Arrhythmias and Treatments
- Periodontal Regeneration and Treatments
- Cardiac and Coronary Surgery Techniques
- Silk-based biomaterials and applications
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiomyopathy and Myosin Studies
- Reconstructive Surgery and Microvascular Techniques
- Atrial Fibrillation Management and Outcomes
- Extracellular vesicles in disease
- Bone and Dental Protein Studies
- Wound Healing and Treatments
- Cardiac Imaging and Diagnostics
Nagoya University
2016-2025
Tokai National Higher Education and Research System
2022-2023
Society of Thoracic Surgeons
2011-2022
Kyoto University
2018
University of Minnesota
2016
Hokkaido Prefectual Police
2014
Nagoya University Hospital
2011
Chubu Rosai Hospital
2011
Japanese Red Cross Nagoya Daiichi Hospital
2011
Kyoto Prefectural University of Medicine
2011
To investigate the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting thoracic aortic prosthetic graft infection. Nine patients with clinically suspected infection underwent FDG-PET/CT scanning. In these patients, diagnoses could not be confirmed using conventional modalities. The patients' clinical courses were retrospectively reviewed. On basis surgical, microbiological and follow-up findings, grafts considered infected 4...
Operative strategies for repairing aortic arch aneurysms should be re-evaluated following recent technical advances. Of 364 patients who underwent repair between 2002 and 2014, 58 were high-risk subjects received isolated hybrid (HAR) via median sternotomy (type I n = 32, type II 1 III 25). During this period, excluding with A dissection or extensive aneurysms, 124 open sternotomy. The in the HAR groups compared. propensity score-matching analysis was applied to adjust baseline risk factors....
Abstract Recently, decellularized tissue has been reported to have the potential regenerate a variety of tissues. However, optimal protocol for esophagus not studied. Here, we investigated effect different decellularization protocols on histology andbiocompatibility esophagi in view future applications engineering. The esophageal mucosal epithelium (EP) from 4‐week‐old Wistar rats was enzymatically dissociated and cultured with growth‐arrested feeder cells. Two methods usingdeoxycholic acid...
Abstract Cancer/testis antigens (CTAs) are considered to be suitable targets for the immunotherapy of human malignancies. It has been demonstrated that in a variety tumors, expression certain CTAs is activated via demethylation their promoter CpG islands. In our study, we have shown while composite 13 30 glioma specimens and newly established cell lines from Japanese population was nearly imperceptible, DNA‐demethylating agent 5‐aza‐2′‐deoxycytidine (5‐aza‐CdR) markedly reactivated CTA cells...
For successful tissue engineering, neovascularization of the implanted is critical. Factors generated by endothelial cells are also considered crucial for process osteogenesis. The direct effects supplementing engineered constructs with cultured progenitor (EPCs) enhancing bone regeneration have not been reported. In this study, we investigated potential EPCs to facilitate in implants and evaluated their influence on regeneration. EPC soluble factors osteogenic differentiation mesenchymal...
Controlling the balance of endothelial cells (ECs) and smooth muscle (SMCs) in blood vessels is critically important to minimize risk associated with vascular implants. Extracellular matrix (ECM) plays a key role controlling cellular balance, suggesting promising source cell-selective peptides. To obtain EC- or SMC-selective peptides, we start by highlighting sequence differences found among ECM molecules as enriched targets for We explored performance tripeptides that are specifically only...
Recently, the effects of stem cell supernatants or exosomes, such as skin wounds, have attracted attention. However, induced pluripotent (iPS) cell-derived exosomes (iPS-Exos) not been investigated in detail. Here, we iPS-Exos on wound healing using an animal model. We isolated from iPS culture media. Control were unused media (M-Exos). first observed morphologic characteristics and examined expression surface antigens. The these migratory response proliferation fibroblasts analyzed well....
Mesenchymal stem cells (MSCs) are known to be capable of suppressing inflammatory responses. We previously reported that intra-abdominal implantation bone marrow-derived MSCs (BM-MSCs) sheet by laparotomy attenuated angiotensin II (AngII)-induced aortic aneurysm (AA) growth in apolipoprotein E-deficient (apoE-/-) mice through anti-inflammation effects. However, cell delivery is invasive; we here demonstrated the effects multiple intravenous administrations BM-MSCs on AngII-induced AA...
Abstract Aortic aneurysm (AA) is a vascular disorder characterized pathologically by inflammatory cell invasion and extracellular matrix (ECM) degradation. It known that regulation of the balance between pro-inflammatory M1 macrophages (M1Ms) anti-inflammatory M2 (M2Ms) plays pivotal role in AA stabilization. We investigated effects M2M administration an apolipoprotein E-deficient (apoE −/− ) mouse model which was induced angiotensin II (ATII) infusion. Mice received intraperitoneal 1...
Device implantation with a generator pocket raises cosmetic concerns regarding external appearance. We present case of successful left bundle branch area pacing and axillary pacemaker via two-incision approach in young female patient, resulting favorable cardiac function satisfaction.
Cell culture in a biomimetic environment is known to improve the mechanical endurance of tissueengineered cardiovascular components. Our goal was generate bioreactor that can reproduce wide range pulsatile flows with completely physiological pressure profile. The morphology and biochemical properties tissue-engineered products were also studied test usefulness this novel bioreactor. combination an outflow valve, compliance chamber, resistant clamps together balloon pumping system able...
<i>Background:</i> Bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into various types of cell, and the extracellular matrix (ECM) is acknowledged to be important for regulation cell functions. In this study, we demonstrated effects ECMs on differentiation human bone MSCs a smooth muscle (SMC) lineage. <i>Methods:</i> Human (hMSCs) were cultured dishes coated with 3 ECM including laminin (LM), collagen type IV (Col-IV) fibronectin 7 days,...
Autologous nerve graft is the most commonly applied treatment for patients with peripheral defect, while application limited because of tissue availability and unfavorable donor site morbidity. To overcome this problem, regeneration using a conduit has been studied. Especially, biodegradable materials considered promising. In study, potential collagen studied special reference to regenerating process nerve. Twelve adult female Beagle dogs weighting 10-12 kg were used. The peroneal was cut...
An aortic aneurysm (AA) is caused by atherosclerosis with chronic inflammation. Mesenchymal stem cells (MSCs) have potential anti-inflammatory properties. In this study, we examined whether an already-formed AA can be treated intravenous injection of bone marrow-derived (BM)-MSCs in a mouse model. was induced apolipoprotein E-deficient mice angiotensin II-infusion for 28 days through sub-cutaneous osmotic mini-pumps. After that, 1 × 106 BM-MSCs (in 0.2 ml saline) or saline as control...