A5084991542- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Stroke Rehabilitation and Recovery
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatology and Skin Diseases
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Cardiac Valve Diseases and Treatments
- Food Allergy and Anaphylaxis Research
- Venous Thromboembolism Diagnosis and Management
- Fatigue and fracture mechanics
- Intensive Care Unit Cognitive Disorders
- Salmonella and Campylobacter epidemiology
- Myasthenia Gravis and Thymoma
- Cardiac tumors and thrombi
- Structural Behavior of Reinforced Concrete
- Concrete Corrosion and Durability
- COVID-19 epidemiological studies
- Infant Health and Development
- Respiratory Support and Mechanisms
- Aquaculture disease management and microbiota
University of California, Irvine
2011-2025
Neurological Surgery
2018-2025
Nagasaki University
2020-2025
Ricoh (Japan)
2010-2024
National Hospital Organization
1993-2024
Eisai (Japan)
2011-2024
Showa University
1983-2024
Nagoya Medical Center
2016-2023
University of California, Irvine Medical Center
2017-2023
Shizuoka City Shimizu Hospital
2012-2022
Background: Endovascular treatment with mechanical thrombectomy (MT) is beneficial for patients acute stroke suffering a large-vessel occlusion, although efficacy highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in delays and worse clinical outcomes compared direct presentation. Methods: STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices Acute Ischemic Stroke) was prospective, multicenter,...
Mechanical thrombectomy with stent retrievers has become standard of care for treatment acute ischemic stroke patients because large vessel occlusion. The STRATIS registry (Systematic Evaluation Patients Treated With Neurothrombectomy Devices Acute Ischemic Stroke) aimed to assess whether similar process timelines, technical, and functional outcomes could be achieved in a real world cohort as the randomized trials.STRATIS was designed prospectively enroll treated United States Solitaire...
Controversy continues to exist regarding optimal blood pressure control in acute hypertensive intracerebral hemorrhage. Persistent marked elevation of the can promote further bleeding, increase cerebral flow, and raise intracranial pressure. Relative hypotension, on other hand, may hypoperfusion with secondary ischemia. This study was designed assess outcome patient groups defined by degree their pretreatment posttreatment pressures.We retrospectively assessed 87 patients who were...
To determine the frequency of early neurologic deterioration with infarct expansion (ENDIE) and poor outcomes among ischemic stroke patients not treated reperfusion therapies because rapidly improving or mild symptoms (RIMS) to study predictive value hyperacute MRI in these patients.We identified consecutive acute undergoing multimodal within 6 hours onset without evidence hemorrhage on imaging. Medical records were reviewed for 48 hours. All deteriorating had repeat ascertain causes...
Background and Purpose— The Stroke PROTECT (Preventing Recurrence Of Thromboembolic Events through Coordinated Treatment) program systematically implements, at the time of acute transient ischemic attack (TIA) or stroke admission, 8 medication/behavioral secondary prevention measures known to improve outcome in patients with cerebrovascular disease. objective this study was determine if high utilization rates previously demonstrated hospital discharge were maintained 90 days after discharge....
Background and Purpose— Mechanical thrombectomy has been shown to improve clinical outcomes in patients with acute ischemic stroke. However, the impact of balloon guide catheter (BGC) use is not well established. Methods— STRATIS (Systematic Evaluation Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter study large vessel occlusion treated Solitaire stent retriever as first-line therapy. In this study, an independent core laboratory,...
Skin colonization at 6 months of age by S. aureus with functional Agr quorum sensing associates later atopic dermatitis development in infants.
The current pipeline for new antibiotics fails to fully address the significant threat posed by drug-resistant Gram-negative bacteria that have been identified World Health Organization (WHO) as a global health priority. New antibacterials acting through novel mechanisms of action are urgently needed. We aimed identify chemical entities (NCEs) with activity against Klebsiella pneumoniae and Acinetobacter baumannii could be developed into treatment infections.
Abstract Background Little is known about snakebites by Naja samarensis, a species unique to the Philippines. The aim here describe clinical and epidemiological characteristics of patients bitten this medically important cobra in Eastern Visayas. Methods A hospital-based prospective study analysed features snakebite attending Visayas Medical Center between June 2022 May 2023. Logistic regression analysis identified factors associated with severity. Results total 175 five fatalities were...
It has been shown that Emdogain ® Gel (Emd-Gel) containing enamel matrix proteins promotes biomineralization, such as osteogenesis and cementogenesis, during the regeneration of periodontal tissues. However, growth factors involved in these activities Emd-Gel remain unclear. In this study, was fractionated into 22 sub-fractions by size exclusion chromatography. The osteoinductive factors, TGF-β BMP, were examined a specific luciferase reporter gene assay. unfractionated Emd-Gel, TGF-β-like...
Pulmonary artery disease in Takayasu's arteritis: angiographic findings.I Yamada, H Shibuya, O Matsubara, I Umehara, T Makino, F Numano and S SuzukiAudio Available | Share
The authors evaluate the usefulness of magnetic resonance (MR) imaging in diagnosis Takayasu arteritis (TA). MR images 77 patients with TA (74 women, three men) were obtained a 1.5-T system, and resulting compared those at conventional angiography. Aortic lesions--including stenosis, dilatation, aneurysms, wall thickening, mural thrombi--were clearly visualized imaging, particularly aortic long-axis images. Further, regurgitation, which occurs frequently TA, was seen cine Also, branch vessel...
All of the Salmonella enteritidis strains isolated from diseased animals (61 strains) and beef (2 in Japan West Germany (1 strain), except for 2 ducks, harbored either a 36-megadalton (Md) plasmid alone or combination with several other plasmids different sizes. It is likely that these 36-Md various S. were derived same origin because their DNAs showed cleavage patterns obtained EcoRI, HindIII, BamHI. We also suggested this native to enteritidis. Tests carried out on two ducks which...
The transcription factor IRF5 has been implicated as a therapeutic target for the autoimmune disease systemic lupus erythematosus (SLE). However, activation status during course and effects of inhibition after onset are unclear. Here, we show that SLE patients in both active remission phase have aberrant interferon-stimulated genes. Partial is superior to full type I interferon signaling suppressing mouse model SLE, possibly due function oxidative phosphorylation. We further demonstrate via...
The levels of relatedness among strains Erysipelothrix rhusiopathiae (serovars 1 through 23 and type N) were estimated by performing DNA-DNA hybridization experiments with the E. tonsillarum, which are two species that have been described. Two distinct DNA groups identified. group strains, representing serovars 1, 2, 4 6, 8, 9, 11, 12, 15 17, 19, 21 N, exhibited more than 73% strain but less 24% tonsillarum. Group 2 included serovar 3, 7, 10, 14, 20, 22, these 66% tonsillarum 27%...
<b><i>Objective:</i></b> To assess the impact of Preventing Recurrence Thromboembolic Events through Coordinated Treatment (PROTECT) Program on achievement its eight secondary prevention goals at time discharge. <b><i>Methods:</i></b> Achievement rates for program discharge were compared in all patients discharged from a university hospital-based stroke service with diagnosis ischemic or TIA during 1-year period after implementation PROTECT vs obtained comparable group admitted to same...
The hypothesis that both activated Kupffer cells and the spleen may be responsible for endotoxin-induced liver injury following partial hepatectomy was investigated. Male rats were divided into a sham group receiving laparotomy alone three groups two-thirds hepatectomy; one given normal saline (NS) solution as vehicle control, received intravenous gadolinium chloride (GC group) (7 mg/kg body weight) 2 days before injection of endotoxin to inhibit cell phagocytosis, third simultaneously...
OBJECTIVE Because of their anatomic configuration, middle cerebral artery (MCA) aneurysms are most often treated with surgical clipping. However, endovascular coil embolization these is an increasingly used alternative. We retrospectively reviewed the and clinical outcomes patients MCA who underwent treatment at our institution. METHODS One hundred fifteen in 115 (mean age, 55.1 years) were by technique from April 1990 to March 2007. Forty-eight (42%) presented acute subarachnoid hemorrhage,...
Abstract Mutations in FLG coding profilaggrin cause ichthyosis vulgaris and are an important predisposing factor for atopic dermatitis. Until now, most case–control studies population‐based screenings have been performed only prevalent mutations. In this study, we established a high‐throughput mutation detection system by real‐time PCR with set of two double‐dye probes conducted comprehensive screening almost all the Japanese‐population‐specific mutations (ten mutations). The present ten...
The Japanese Guideline for Childhood Asthma (JGCA) 2020 is a translation of the Pediatric Treatment and Management (JPGL) 2017 into English, which was published by Society Allergy Clinical Immunology. It makes recommendations best practices in management childhood asthma, including acute exacerbations non-pharmacological pharmacological management. These guidelines will be interest to non-specialist physicians involved care children with asthma. In JPGL, JPGL2017 first evidence-based updated...
Summary Background Bifidobacterium is a dominant genus in the intestinal microbiota of infants and comprises many different species. A series studies performed northern Europe showed differences composition species between allergic healthy controls. Additional are needed to confirm this observation. Objective To investigate fecal controls Japan, using molecular methods. Methods Full‐term born babies were followed up 6 months age at local hospital rural Japan. The presence or absence allergy...