A5025754055- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Sleep and Wakefulness Research
- Contact Dermatitis and Allergies
- Urban and spatial planning
- Evacuation and Crowd Dynamics
- Respiratory viral infections research
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Respiratory and Cough-Related Research
- Urticaria and Related Conditions
- Mast cells and histamine
- Autophagy in Disease and Therapy
- Health and Medical Studies
- Education, Safety, and Science Studies
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
- Prion Diseases and Protein Misfolding
- Cancer Mechanisms and Therapy
- Cultural and Historical Studies
University of Fukui
2015-2025
Osaka Rosai Hospital
2025
Japan Pediatric Society
2024
Nihon Fukushi University
2020-2023
Setsunan University
2019-2021
The University of Texas Medical Branch at Galveston
2009-2015
Nara Institute of Science and Technology
2015
Nagoya City University
2006-2012
Galveston College
2009-2011
Hiroshima Institute of Technology
2009
The Japanese Guideline for Childhood Asthma (JGCA) 2020 is a translation of the Pediatric Treatment and Management (JPGL) 2017 into English, which was published by Society Allergy Clinical Immunology. It makes recommendations best practices in management childhood asthma, including acute exacerbations non-pharmacological pharmacological management. These guidelines will be interest to non-specialist physicians involved care children with asthma. In JPGL, JPGL2017 first evidence-based updated...
Background/Objectives: Combination therapy with atezolizumab and bevacizumab (ATZ/BEV) is extremely effective yields a high response rate in patients hepatocellular carcinoma (HCC). In this study, the efficacy of adding locoregional to ATZ/BEV stable disease (SD) HCC was investigated. Methods: One hundred five who were treated or lenvatinib (LEN) as first-line chemotherapy for unresectable evaluated on basis modified RECIST criteria. SD whose initial antitumor effect achieved received...
Abstract Background Cutaneous exposure to food antigen through impaired skin barrier has been shown induce epicutaneous sensitization, thereby causing IgE‐mediated allergies. Objective We examined whether impairment following sensitization exacerbates Methods BALB /c mice were epicutaneously sensitized by repeated application of ovalbumin ( OVA ) MC 903‐pretreated ear for 48 hours weekly and then intragastrically challenged with . After the first oral challenge, was disrupted topical 903 or...
Respiratory syncytial virus (RSV) infection causes asthma-like symptoms in infants and young children. Although an increase several mediators the airway during RSV has been reported, mechanisms involved inflammation are not fully understood. The aim of this study was to investigate immunological deviation associated with by measuring cytokine chemokine levels infection.One hundred ten children under 3 years age respiratory were enrolled from November 2004 through January 2005. Nasopharyngeal...
Allergic asthma is characterized by airway eosinophilia, increased mucin production and allergen-specific IgE. Fc gamma receptor IIb (FcgammaRIIb), an inhibitory IgG receptor, has recently emerged as a negative regulator of allergic diseases like anaphylaxis rhinitis. However, no studies to date have evaluated its role in asthma. Our main objective was study the FcgammaRIIb lung inflammation. We used murine model Inflammation quantified BAL inflammatory cells production. expression measured...
Background A series of epidemiologic studies have identified the fungus Alternaria as a major risk factor for asthma. The airway epithelium plays critical role in pathogenesis allergic These reports suggest that activated epithelial cells can produce cytokines such IL-25, TSLP and IL-33 induce Th2 phenotype. However epithelium-derived products mediate pro-asthma effects are not well characterized. We hypothesized exposure to releasing differentiation. Methodology/Principal Finding used ELISA...
Interleukin-33 appears to play important roles in the induction of allergic airway inflammation. However, whether IL-33 is involved remodeling remains unclear. Because fibrocytes contribute tissue setting chronic inflammation, we examined effects on fibrocyte functions. Fibrocytes were generated vitro from peripheral blood mononuclear cells by culturing presence platelet derived growth factors and stimulated with IL-33. enhanced cell proliferation,<mml:math...
Newborn males are more sensitive to brain injury than newborn females are. The aim of the present study was find an explanation for this. We used neuron-specific enolase (NSE) levels in cerebrospinal fluid (CSF) classification 32 newborns (19 and 13 females) on their fifth postnatal day. NSE were higher normal (8.4 +/- 1.6 ng/mL) 10 6 were, respectively, considered asphyxiated male female groups. remaining newborns, 9 7 females, had CSF samples measured 12 cytokines, using a cytokine array...
Noninvasive and child-friendly biomarkers are important tools for understanding the various phenotypes of childhood asthma. Objective: The aim this study was to examine usefulness salivary surfactant protein (SP) D in assessing pathophysiology asthma.We measured concentrations SP-D forced oscillation technique (FOT) indexes 19 healthy controls 21 asthmatic children. Regression equations predictive values FOT were generated from controls. We analyzed correlations between concentration...
【目的】教職員がアナフィラキシーを理解し初期対応を可能にするための教育は学校生活の安全のために必要不可欠である．教職員に対するエピペン®の実技指導を含む講習の有効性を検討した． 【方法】福井市の小中学校教職員を対象に，食物アレルギーとアナフィラキシーに関する講習とエピペントレーナーを用いての実技指導を行った．講習会前後でアナフィラキシー対応に関する意識の違いをアンケート調査により比較検討した． 【結果】講習前には，エピペン®認知度は97％であったが，使用法まで理解している者は29％にすぎなかった．使用に対する不安は，使用のタイミングが82％と最も多く，使用後の保護者からのクレームが68％であった．養護教諭や現場の教諭がエピペン®を施行するとした割合は，講習前の41％，28％から，講習後には63％，48％と著増した．実技指導により使用への抵抗感が軽減したとの回答が増加した． 【結論】講演会に実技指導を加えることは，アナフィラキシーに対する理解を深め，エピペン®使用の不安を軽減する上で有用と考えられた．
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major burden for health care systems worldwide, and threat to our daily lives. Various effective ingredients against SARS-CoV-2 were already reported, however, since products contain various ingredients, it also important evaluate the effectiveness commercially available disinfectants per se. In this study, virucidal efficacy forty-eight evaluated according standardized suspension method EN 14476...
We previously reported that brotizolam, but not suvorexant, delayed recovery from isoflurane anesthesia in mice. However, the effects of hypnotics may be altered by circadian rhythm. Locomotor activity was measured using sighted (ICR and C57BL/6J) blind (FVB/N C3H/HeN) mice, on were compared during light dark periods. In induced brotizolam period, while suvorexant period. C57BL/6J marked, observed low last 6 h period similar to identical both periods, did influence anesthesia. These results...
Abstract Described herein is the case of an 8‐month‐old girl with atypical food protein‐induced enterocolitis syndrome due to rice. She presented vomiting and poor general activity 2 h after ingestion boiled Oral challenge test using high‐pressure retort‐processed rice was negative, but re‐exposure elicited gastrointestinal symptoms. On western blot analysis patient's serum found contain IgE bound crude protein extracts from seed or rice, not The major bands were detected in electrophoresed...
目的:アクティブラーニングを用いた小児アレルギー教育セミナーにおいてオンライン式が対面式と同様の学習到達度,行動変容を促すのか明らかにする.
We investigated the effects of sleep-inducing agents with different mechanisms action on loss righting reflex induced by isoflurane or a mixture medetomidine, midazolam, and butorphanol (MMB), followed atipamezole reversal. Chlorpromazine brotizolam delayed recovery from both types anesthesia, whereas melatonin receptor agonist ramelteon had no effect. The orexin antagonist suvorexant anesthesia only in case MMB, while sleep-promoting supplement glycine isoflurane. These results suggest that...
Authors discussed on a method to estimate the fire damage area in existing office buildings by beforehand questionnaire sheet survey. A was developed taking into consideration score pointed not only substantiality degree of hardware factors, but also software factors. survey conducted experimentally 185 with above-mentioned sheet. As conclusion, authors made clear what might calculate safety index be able perform comparison performance between building easily sheet, and before firebreak.