A5004305996- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Photosynthetic Processes and Mechanisms
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Polysaccharides and Plant Cell Walls
- Mitochondrial Function and Pathology
- Pharmacological Effects of Natural Compounds
- Alkaline Phosphatase Research Studies
- Photopolymerization techniques and applications
- Respiratory Support and Mechanisms
- Neurological and metabolic disorders
- Eosinophilic Esophagitis
- Vitamin K Research Studies
- Xenotransplantation and immune response
- Organ Transplantation Techniques and Outcomes
- Estrogen and related hormone effects
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Photodynamic Therapy Research Studies
- Enzyme Structure and Function
- Mechanical Circulatory Support Devices
- Restraint-Related Deaths
- Metal-Catalyzed Oxygenation Mechanisms
Okayama University Hospital
2014-2025
Okayama University
2016-2025
Tokyo Medical University Hachioji Medical Center
2020-2023
Tokyo Medical University
2000-2019
Tokyo Medical University Hospital
2015-2019
Toyama University Hospital
2013-2017
National Sagamihara Hospital
2013-2017
Tokyo University of Pharmacy and Life Sciences
1995-2001
Kitasato University Hospital
2001
Kitasato University
1999
The Japanese Guideline for Childhood Asthma (JGCA) 2020 is a translation of the Pediatric Treatment and Management (JPGL) 2017 into English, which was published by Society Allergy Clinical Immunology. It makes recommendations best practices in management childhood asthma, including acute exacerbations non-pharmacological pharmacological management. These guidelines will be interest to non-specialist physicians involved care children with asthma. In JPGL, JPGL2017 first evidence-based updated...
Photoinitiators are used in the manufacture of many daily products, and may produce harmful effects due to their cytotoxicity. They have also been detected human serum. Here, we investigated histamine-producing HMC-1 cells inflammatory cytokine release RAW264 for four photoinitiators: 1-hydroxycyclohexyl phenyl ketone; 2-isopropylthioxanthone; methyl 2-benzoylbenzoate; 2-methyl-4´-(methylthio)-2-morpholinopropiophenone. All promoted histamine production cells; however, they did not...
The extrinsic 33-kDa protein of photosystem II (PSII) was intramolecularly cross-linked by a zero-length cross-linker, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. resulting rebound to urea/NaCl-washed PSII membranes, which stabilized the binding manganese as effectively untreated protein. In contrast, oxygen evolution not restored protein, indicating that and manganese-stabilizing capabilities are retained but its reactivating ability is lost intramolecular cross-linking From measurements...
The extrinsic 33-kDa protein of photosystem II (PSII) was modified with various reagents, and the resulting proteins were checked for ability to rebind PSII reactivate oxygen evolution. While modification more than eight carboxyl groups aspartyl glutamyl residues glycine methyl ester did not affect rebinding reactivating capabilities, amino lysyl either N-succinimidyl propionate or 2,4,6-trinitrobenzene sulfonic acid guanidino arginyl 2,3-butanedione resulted in a loss capabilities protein....
A recent in vitro study reported that the photoinitiator 2-isopropylthioxanthone (2-ITX) is an endocrine-disrupting compound (EDC). However, it not clear whether other photoinitiators such as 1-hydroxycyclohexyl phenyl ketone (1-HCHPK) and 2-methyl-4′-(methylthio)-2-morpholinopropiophenone (MTMP) produce effects. The purpose of this was thus to assess association between estrogenic activity exposure photoinitiators. For estimation proliferative effect photoinitiators, E-screen assay used....
Abstract We estimated the pharmacological efficacy of vitamin K 1 ( VK ) and 2 on mitogen‐activated peripheral blood mononuclear cells PBMC s) paediatric atopic dermatitis AD patients. suppressed in vitro proliferation T‐cell s In contrast, had little effect proliferation. The IL ‐2 production from activated patients significantly increased P < .05), while decreased by 100 μmol L −1 .01). addition, reduced percentage CD 4+ 25+ s. These results suggest that can modulate function
Uncertain symptoms often emerge during an oral food challenge (OFC), and Open-OFCs with those uncertain mild are ordinarily regarded as positive. Double-blind placebo-controlled challenges should be conducted to determine these associations. Nevertheless, studies regarding the diagnosis of allergy lacking. We examined diagnostic decision for a based on Open-OFC.We Open-OFC between August 2005 April 2012 2271 cases who suspected allergic hen's eggs, cow's milk, or wheat. For primary...
Zymosan, a particulate β-glucan preparation from Saccharomyces cerevisiae, shows various biological activities, including anti-tumor activity. We have previously shown that soluble initiated activity was long-lived and effective even by prophylactic treatment at 1 month prior to tumor challenge. However, the zymosan relatively short-lived. Antigen-specific responses of mice might be causative mechanism. In this paper, were immunized with antibody production antigen-specific lymphocytes...
Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related deaths worldwide. Sorafenib, a molecular-targeted drug, multi-target oral anti-neoplastic drug that used as first-line treatment for patients with advanced Human HCC. An increase in expression cyclooxygenase-2 (COX-2) protein and sequential production prostaglandin (PG) E2 were previously shown to significantly enhance carcinogenesis. Although synergistic and/or additive effects various COX inhibitors have been...
Over 20 kinds of steroids, tacrolimus ointments, and cyclosporine capsules are usually recommended for the treatment atopic dermatitis (AD), depending on symptoms patients. However, several side effects sometimes occur with extensive use these agents pediatric AD The purpose this study was to explore whether vitamin K2 could be a new immunosuppressive candidate patients AD.The efficacy evaluated through cell-culture procedure using mitogen-activated peripheral blood mononuclear cells (PBMCs)...
Vitamin K2 is suggested to have a suppressive effect on the peripheral blood mononuclear cells (PBMCs) of pediatric atopic dermatitis patients. We examined molecular targets vitamin suppress proliferation and cytokine production in T-cell mitogen-activated PBMCs patients from viewpoint protein kinase signaling molecules. The study population included 16 21 healthy subjects. concanavalin A-activated PBMC was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell...
Abstract Spontaneous pneumomediastinum is a benign, self‐limited condition that mainly affects young people. In this report, we present four cases of uncommon and review the current literature. Two had no prior significant medical history: one history asthma other underwent regular outpatient treatment for anorexia nervosa. The three patients who were not anorexic spontaneously improved within few days. However, patient with nervosa took 2 months to recover. It appears spontaneous an...
Intraperitoneally or intravenously administered (1→3)-β-D-glucan remained in the liver and spleen, for a long time without major structural changes, but priming activity to lipopolysaccharide (LPS)-triggered tumor necrosis factor-α (TNF-α) production was reduced more quickly. The relationship between deposited glucan contents antitumor examined by comparing kinetics of using solid form Sarcoma 180 ICR mice. We used three kinds soluble glucans, sonifilan (SPG), grifolan (GRN), SSG,...
Background: In general practice, a wide variety of patients often present with various complaints. Some them have multiple somatic symptoms, and it is possible for practitioner to miss an organic disease. this cross‐sectional study, we retrospectively examined the correlation between number complaints prevalence diseases in order elucidate clues help detect Method: We evaluated 386 new walk‐in outpatients who presented department medicine at Toyama University Hospital January 2014 December...
The Recap of atopic eczema (RECAP), a new core outcome the dermatitis trial, was translated into Japanese and linguistically validated.Translation accomplished according to ISPOR (International Society for Pharmacoeconomics Outcome Research) guidelines basic scale translation. translation process included two forward translations, reconciliation with native English speakers, third-party back translation, cognitive debriefing, review harmonization by original authors. Twenty-seven pediatric...
小児気管支喘息患者に対してダニアレルゲン特異的免疫療法（皮下免疫療法，舌下免疫療法）とプラセボを比較した試験は16編あり，その中で皮下免疫療法では喘息症状，頓用薬の使用，全身性ステロイド投与，長期管理薬の使用量，呼吸機能において，舌下免疫療法では喘息症状，呼吸機能においてダニアレルゲン特異的免疫療法が効果的であることが示された．しかしエビデンスレベルが総じて低く，日本人小児を対象とした試験がなかった．また本邦では皮下免疫療法は喘息への保険適応があるものの，舌下免疫療法は現時点でアレルギー性鼻炎のみが適応となっており，その実施には喘息が十分にコントロールされていることが注意点として挙げられている．アレルゲン特異的免疫療法には副反応も少なからず報告されており，治療効果と副反応のバランスを考慮していく必要がある．
Pyomyositis is a purulent skeletal muscle infection that arises from hematogenous spread, and usually accompanied by abscess formation. This condition commonly seen in the tropics, but has recently been recognized temperate regions. We report case of pectoralis pyomyositis an elderly Japanese woman without any serious underlying medical conditions. The course illness this differed tropical cases. should consider as important complication bacteremia, particularly because pathology no longer...
This article was originally published online on 23 April 2013 The purpose of this study is to establish grading system for the evaluation systemic reactions (SR) at oral food challengeand investigate relationship between severity SR using and treatment. From June 2008 2012, assessed double-blind placebo-controlled challenge test (DBPCFC) evaluate if they were candidates rush immunotherapy or not. medical records 342 patients who showed positive reaction DBPCFC analyzed. A hundred forty-one...