A5019201612- Design Education and Practice
- Gastric Cancer Management and Outcomes
- Manufacturing Process and Optimization
- Ultrasound and Hyperthermia Applications
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Xenotransplantation and immune response
- Gastrointestinal disorders and treatments
- Organ Transplantation Techniques and Outcomes
- Architecture and Computational Design
- Liver Disease Diagnosis and Treatment
- BIM and Construction Integration
- Hepatocellular Carcinoma Treatment and Prognosis
- Color perception and design
- Advanced MRI Techniques and Applications
- Modular Robots and Swarm Intelligence
- MRI in cancer diagnosis
- Yersinia bacterium, plague, ectoparasites research
- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Diabetes Treatment and Management
- Colorectal and Anal Carcinomas
- Heme Oxygenase-1 and Carbon Monoxide
Tokyo Women's Medical University Adachi Medical Center
2022-2024
Iwate Prefectural Central Hospital
2014-2024
University of Occupational and Environmental Health Japan
2024
Gunma University
1975-2023
Takushoku University
2022
National Hospital Organization Takasaki Medical Center
2020-2021
Chiba University
2016-2021
Tsurumi University
2015-2021
Keio University
2008-2019
Teikyo University
2015-2018
Mouse-to-rat cardiac transplants survive long term after transient complement depletion by cobra venom factor and T cell immunosuppression cyclosporin A. Expression of heme oxygenase-1 (HO-1) the graft vasculature is critical to achieve survival. In present study, we asked whether this protective effect was attributable generation one catabolic products HO-1, carbon monoxide (CO). Our data suggests that case. Under same immunosuppressive regimen allows mouse-to-rat (i.e., plus A), inhibition...
Diet composition alters the metabolic states of adipocytes and hepatocytes in diabetes. The effects dipeptidyl peptidase-4 (DPP-4) inhibition on adipose tissue inflammation fatty liver have been obscure. We investigated extrapancreatic DPP-4 visceral fat liver.We diet-induced changes β-cell-specific glucokinase haploinsufficient (Gck(+/-)) diabetic mice. challenged animals with a diet containing combination sucrose oleic acid (SO) or linoleic (SL). Next, we assessed inhibitor,...
Yersinia pseudotuberculosis infection was diagnosed in 12 children on the basis of recovery organism from stool cultures and a 4-fold or greater titer change agglutinating antibody. Eight isolates were recovered only after cold enrichment. Clinical findings 50% more patients fever, rash, diarrhea, desquamation, strawberry tongue, vomiting, red cracked lips, abdominal pain, arthralgias, hepatomegaly conjunctivitis. The patients' clinical manifestations courses illness resembled those Izumi an...
Abstract Purpose To utilize a microwave coagulator for MR‐guided interstitial thermal therapy of liver tumors as clinically feasible heating device. Materials and Methods thermocoagulation was carried out 34 times in 30 patients with (eight hepatocellular carcinoma, 22 metastatic tumors) using 0.5 T open configuration MR system. Results Percutaneous puncture could be accomplished both accurately safely while monitoring real‐time magnetic resonance imaging (MRI). Using notch filter, images...
The prevalence of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is increasing with the growing epidemics obesity diabetes. NAFLD encompasses a clinicopathologic spectrum ranging from isolated hepatic steatosis to NASH, which more aggressive form disease, cirrhosis and, finally, hepatocellular carcinoma (HCC). exact mechanism behind development HCC in NASH remains unclear; however, it has been established that important risk factor HCC. Metformin recently drawn attention...
The incidence of Yersinia pseudotuberculosis isolation from humans, animals, water, and pork in Japan is presented on the basis a review literature serotyping 633 strains referred to our laboratory. Most belonged serogroup 4b, followed frequency by serogroups 3, 1b, 5b, 5a, others, whereas 1a has not been detected. Although were isolated 11 species none birds.
Hamster to rat cardiac xenografts undergo delayed rejection as compared with the hyperacute of discordant xenografts. Elicited xenoreactive Abs (EXA) are thought initiate hamster xenograft rejection. In this study, we demonstrate that following transplantation a heart, rats generated high levels EXA. Adoptive transfer into naive recipients purified IgM, IgG2b, or IgG2c, but not IgG1 IgG2a EXA, induced in complement-dependent manner. Ability EXA cause correlated complement activation,...
Hamster hearts transplanted into transiently complement-depleted and continuously cyclosporin A (CyA)-immunosuppressed rats survive long-term despite deposition of anti-donor IgM Abs complement on the graft vascular endothelium. This phenomenon is referred to as "accommodation." The hypothesis tested here that accommodated xenografts are resistant could result in rejection naive xenografts. After first hamster had been surviving cobra venom factor (CVF) + CyA-treated for 10 days, a time when...
Aim: Ezetimibe selectively blocks intestinal cholesterol absorption by inhibiting Niemann-Pick C1-like 1 (NPC1L1) and reducing LDL (LDL-C). In animals, ezetimibe reversed diet-induced obesity, liver steatosis, insulin resistance. humans, its potential effects on steatosis resistance have been suggested. We investigated the of postprandial hyperlipidaemia hyperglycaemia in obese subjects with dyslipidaemia a double-blind randomized crossover trial.Methods: Twenty men hypertriglyceridaemia...
Oxidative stress increases the production of predominant mucin MUC5AC in airway epithelial cells and is implicated pathogenesis bronchial asthma chronic obstructive pulmonary disease. impairs mitochondria, releasing mitochondrial DNA into cytoplasm inducing inflammation through intracytoplasmic sensor STING (stimulator interferon genes). However, role innate immunity remains unknown. We aimed to elucidate under oxidative stress. Human cell line (NCI-H292) normal human were used confirm
We compared the performance efficiency of a newly developed small-caliber colonoscope (PCF-PQ260 L) with passive bending, high force transmission, and an outer diameter 9.2 mm that standard colonoscope, in female male patients, particularly regard to passage through acute angulations or into proximal colon.A total 330 patients were randomly allocated undergo (n = 164) 166) colonoscopy. The assessed for pain using visual analogue scale (0 none, 100 extremely painful), cecal intubation,...
Abstract: Background: The rate of metabolism in the intestine oral administered FK506 decreases as passes on to lower intestine. In transplant recipients with diarrhea given FK506, main areas for absorption shift intestine, where ability metabolize is weaker. Therefore it considered likely that when diarrhea, blood concentration will be higher. Material and Methods: Twenty experiencing episodes were investigated determine trough level time required return obtained before diarrhea. AUC 0−4h C...
Alloreactive memory T cells mediate accelerated rejection. We investigated the effect of polyclonal anti-T-cell antibody (ALS) and rapamycin (RAPA) on skin allograft survival in naïve or alloantigen-primed mice. ALS prolonged graft both T-cell depletion by was associated with increased CD4(+)CD44(hi)OX40(+) CD8(+)CD44(hi)CD122(+) cells. Addition RAPA to extended mice, but had no secondary In adoptive transfer experiments, inhibited alloantigen-stimulated proliferation rejection contrast,...
Studies from overseas have indicated that postprandial glucose excursions are predominant in subjects with moderate hyperglycemia, while fasting hyperglycemia become the abnormality worsening of hyperglycemia; however, few studies yet investigated correlation between HbA1c and and/or Japanese subjects. We overall diabetic status, as assessed by measurement HbA1c, patients type 2 diabetes. Blood (BG) concentrations were determined state (8:00 A.M.), during phases (at 10:30 A.M., 2:30 P.M....
In a curved surface design, the overall shape features that emerge from combinations of elements are important. However, controlling in profiles is difficult using conventional microscopic information such as dimension. Herein two types macroscopic information, curvature entropy and quadrature entropy, quantitatively represent shape. The calculated by distribution, represents complexity (one features). an improvement introducing Markov process to evaluate continuity approximate human...
Abstract We transplanted hamster hearts into rats that had been sensitized to cardiac grafts 5 days earlier as a model for discordant xenotransplantation. Sensitized high serum levels of elicited anti-donor IgM and IgG caused hyperacute rejection. Transient complement inhibition with cobra venom factor (CVF) plus daily continuing cyclosporin A (CyA) prevented However, underwent delayed xenograft rejection (DXR). DXR involved associated Ab-dependent cell-mediated rejection, because depletion...