A5051937204- Heme Oxygenase-1 and Carbon Monoxide
- Hemoglobin structure and function
- Iron Metabolism and Disorders
- Analytical Chemistry and Chromatography
- Neonatal Health and Biochemistry
- Dialysis and Renal Disease Management
- Trace Elements in Health
- Mass Spectrometry Techniques and Applications
- Sulfur Compounds in Biology
- Hemoglobinopathies and Related Disorders
- Advanced Chemical Sensor Technologies
- Antioxidant Activity and Oxidative Stress
- Renal Diseases and Glomerulopathies
- Adipokines, Inflammation, and Metabolic Diseases
- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Vitamin C and Antioxidants Research
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Muscle and Compartmental Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac electrophysiology and arrhythmias
- Chemical Thermodynamics and Molecular Structure
- Folate and B Vitamins Research
University of Debrecen
2016-2025
Hungarian Academy of Sciences
2014-2024
Budapest University of Technology and Economics
2002-2024
University of Brescia
2020
B & B
2014
Budapest University of Economics and Business
2010-2012
University of Minnesota
1992-2010
James Graham Brown Foundation
2002-2010
University of Louisville
2002-2010
Instituto Gulbenkian de Ciência
2010
Phagocyte-mediated oxidant damage to vascular endothelium is likely involved in various vasculopathies including atherosclerosis and pulmonary leak syndromes such as adult respiratory distress syndrome.We have shown that heme, a hydrophobic iron chelate, rapidly incorporated into endothelial cells where, after little 1 h, it markedly aggravates cytotoxicity engendered by polymorphonuclear leukocyte oxidants or hydrogen peroxide (H20z).In contrast, however, if cultured are briefly pulsed with...
Heme proteins such as myoglobin or hemoglobin, when released into the extracellular space, can instigate tissue toxicity. Myoglobin is directly implicated in pathogenesis of renal failure rhabdomyolysis. In glycerol model this syndrome, we demonstrate that kidney responds to inordinate amounts heme by inducing heme-degradative enzyme, oxygenase, well increasing synthesis ferritin, major cellular repository for iron. Prior recruitment response with a single preinfusion hemoglobin prevents and...
Iron-derived reactive oxygen species are implicated in the pathogenesis of various vascular disorders including atherosclerosis, vasculitis, and reperfusion injury. The present studies examine whether heme, when liganded to physiologically relevant proteins as hemoglobin, can provide potentially damaging iron intact endothelium. We demonstrate that reduced ferrohemoglobin, while relatively innocuous cultured endothelial cells, oxidized ferrihemoglobin (methemoglobin), greatly amplifies...
Mouse-to-rat cardiac transplants survive long term after transient complement depletion by cobra venom factor and T cell immunosuppression cyclosporin A. Expression of heme oxygenase-1 (HO-1) the graft vasculature is critical to achieve survival. In present study, we asked whether this protective effect was attributable generation one catabolic products HO-1, carbon monoxide (CO). Our data suggests that case. Under same immunosuppressive regimen allows mouse-to-rat (i.e., plus A), inhibition...
Objective— We investigated whether red cell infiltration of atheromatous lesions promotes the later stages atherosclerosis. Methods and Results— find that oxidation ferro (FeII) hemoglobin in ruptured advanced occurs generating ferri (FeIII) via more extensive ferrylhemoglobin (FeIII/FeIV=O). The protein marker dityrosine accumulates complicated lesions, accompanied by formation cross-linked hemoglobin, a hallmark ferrylhemoglobin. Exposure normal cells to lipids derived from causes...
Ferritin plays a central role in iron metabolism and is made of 24 subunits 2 types: heavy chain light chain. The ferritin (FtH) has ferroxidase activity that required for incorporation limiting toxicity. purpose this study was to investigate the FtH acute kidney injury (AKI) renal handling by using proximal tubule–specific FtH-knockout mice (FtHPT–/– mice). FtHPT–/– had significant mortality, worse structural functional injury, increased levels apoptosis rhabdomyolysis cisplatin-induced...
C.E.R.A., a continuous erythropoietin receptor activator, is in development to provide anemia correction and stable maintenance of hemoglobin (Hb) levels at extended administration intervals patients with chronic kidney disease (CKD). This study examined its efficacy safety when administered up once monthly who have CKD are on dialysis randomly convert directly from epoetin alpha or beta one three times weekly.In this three-arm, comparator-controlled, open-label, randomized, parallel-group,...
Abstract Hemochromatosis is a known cause of osteoporosis, and iron overload has deleterious effects on bone. Although its association with osteoporosis long been recognized, the pathogenesis exact role have undefined. Bone an active tissue constant remodeling capacity. Osteoblast (OB) development maturation are under influence core binding factor α-1 (CBF-α1), which induces expression OB-specific genes, including alkaline phosphatase, important enzyme in early osteogenesis, osteocalcin,...
Despite the prevalence and recognition of its detrimental impact, clinical complications sepsis remain a major challenge. Here, we investigated effects myeloid ferritin heavy chain (FtH) in regulating pathogenic sequelae sepsis. We demonstrate that deletion FtH leads to protection against lipopolysaccharide-induced endotoxemia cecal ligation puncture (CLP)-induced model as evidenced by reduced cytokine levels, multi-organ dysfunction mortality. identified such is predominantly mediated...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopper(II)-catalyzed oxidation of catechol by molecular oxygen in aqueous solutionJozsef Balla, Tamas Kiss, and Reginald F. JamesonCite this: Inorg. Chem. 1992, 31, 1, 58–62Publication Date (Print):January 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/ic00027a012https://doi.org/10.1021/ic00027a012research-articleACS PublicationsRequest reuse permissionsArticle...
Background and Purpose— Several factors have been held responsible for the development of atherosclerosis. To avoid masking effect age, we evaluated correlates carotid atherosclerosis in patients <55 years age. Methods— Plasma lipids, oxidative resistance low-density lipoprotein, homocysteine, inflammatory markers, plasma viscosity, red cell deformability were measured fasting blood samples 100 subjects: 45 with >30% stenosis internal artery, 20 occlusion, 35 control subjects. Stenosis...
Several pathologic conditions are associated with hemolysis, i.e. release of ferrous (Fe(II)) hemoglobin from red blood cells. Oxidation cell-free produces (Fe(III)) methemoglobin. More extensive oxidation (Fe(III)/Fe(IV) O) ferryl hemoglobin. Both methemoglobin and thought to contribute the pathogenesis hemolytic disorders. We show hereby that hemoglobin, but not or methemoglobin, acts as a potent proinflammatory agonist induces vascular endothelial cells in vitro rearrange actin...